Karishma

Bullous systemic lupus erythematosus

• Authors Details :  
• Gerado Rivera Silva,  
• Pablo Martinez Fernandez

Journal title : Yemen Journal of Medicine

Publisher : Mansa STM Publishers

Online ISSN : 2583-4614

Page Number : 58-59

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A 25-year-old male presented with vaguely painful and pruritic vesicles and bullae on the oral cavity, abdomen, and superior limbs with symmetrical dissemination, which appeared over the past 3 weeks. No clinical history of importance. The physical examination showed a pallid and prostrated patient, with arterial hypertension (190/110); with several symmetrical dermal vesicles and bullae located on the abdomen and superior limbs (Fig. 1) and on the oral cavity varying from 1.5mm to 4 cm. No lymphadenopathy and sigs of arthritis were identified. Laboratory tests revealed a complete blood cell count with hemoglobin levels of 10.5 g/dL (12.7–15.7 g/DL), leukocytes of 2956/mm3 (4.3–10.7 × 103), and platelet count of 120,000/mm3 (150–350 × 103). Urinalysis shown proteinuria, hematuria, and leukocyturia. The direct Coombs assay, anti-nuclear antibodies, anti-double-stranded DNA, and anti-histone were positive. Histopathological analysis reported subepidermal discontinuity associated with neutrophilic infiltrate and direct immunofluorescence was positive for IgG, staining the basement membrane. Elisa was positive for antibodies against type VII collagen. The diagnosis was bullous systemic lupus erythematosus (BSLE) and he was treated successful with rituximab due to poor response to steroid use.

Article DOI & Crossmark Data

DOI : https://doi.org/10.32677/yjm.v2i1.3789

Article Subject Details

• Dermatology
• Rheumatology

Article Keywords Details

• Autoimmune bullous diseases
• Bullous Systemic Lupus Erythematosus (BSLE)
• Lupus nephritis
• Type VII collagen antibodies
• Ystemic lupus erythematosus (SLE)

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