Evaluating the effects of insulin, metformin and glibenclamide on the pups’ prefrontal cortex and oxidative stress markers of streptozotocin-induced diabetic pregnant rats

There is an upsurge in gestational diabetes mellitus with many devastating consequences for the mother and developing fetus. Insulin therapy remains a mainstay. However, insulin is expensive and comes with the pain of multiple injections. Therefore, there is a need to explore commonly administered oral hypoglycemic agents to cater for the increasing gestational diabetes mellitus-associated neurological complications. This study assesses the effects of glibenclamide, metformin and insulin on the pups’ prefrontal cortex in diabetic pregnant rats. 35 sexually matured adult female rats weighing between 120 g and 160 g were used and assigned into five groups (A to E) of seven rats each group. Diabetes was induced by streptozotocin (45 mg/kg and 35 mg/kg; ip). Hyperglycemic rats were treated with insulin (1.0 UI daily), metformin (200 mg/kg/day) and glibenclamide (0.6 mg/kg/day). Body weight and blood glucose levels were evaluated. Rats were sacrificed at 18-day gestation, the pups were harvested, and their brains were processed for tissue oxidative stress markers and various histological examinations. Glibenclamide and metformin caused a significant blood glucose reduction at 37.9% and 40.7%, respectively, compared to the insulin group (33.09%). There was no significant difference in the body-organ ratio in rats treated with metformin when compared to rats treated with insulin. Metformin and glibenclamide had a significant increase in tissue glutathione reductase and a decrease in malondialdehyde compared with insulin and diabetic control groups. The pups’ prefrontal cortex showed degenerated neuronal cells in the diabetic control animals. The diabetic rats treated with metformin and glibenclamide showed improved pyramidal neurons compared with diabetic and insulin groups. This study suggests that metformin and glibenclamide glycemic control may prevent and improve antioxidant enzymes and reverse some neurotoxic effects caused by streptozotocin-induced diabetes in rats.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Metronidazole-induced neurotoxicity: is iron a contributing factor?

Metronidazole-induced neurotoxicity is a rising challenge in managing susceptible infections. The mechanisms involved in metronidazole-induced neurotoxicity are not fully unraveled. This study aimed to explore the effect of metronidazole on iron homeostasis in SH-SY5Y neuroblastoma cells. Confluent SH-SY5Y neuroblastoma cells were treated with different concentrations of 1.0, 10, 25, 50, 100, and 250 µM of metronidazole only or in combination with 20 µM iron. DMSO or culture media was used as control. Viability and ferritin assays were conducted on the treated cells. The treatments were for 24 hours, 48 hours, and 72 hours, respectively. In the viability assay, doses of metronidazole reduced the viability of SH-SY5Y neuroblastoma cells in a time and concentration-dependent manner. After 24-hour treatment, 250 µM metronidazole significantly reduced cell viability while 50 µM, 100 µM and 250 µM metronidazole reduced considerably viability only after 48-hour and 72-hour compared with control. Different doses of metronidazole 50 µM, 100 µM, and 250 µM in 20 µM iron reduced viability in a time-dependent manner in all the test periods. Metronidazole also induced a time- and concentration-dependent increase (p<0.05) in cellular iron uptake in the 48-hour and 72-hour treated cells in concentrations above 25 µM metronidazole. It is concluded that metronidazole induces a time and concentration-dependent iron overload and consequent cell death in SH-SY5Y neuroblastoma cells and this may contribute to the mechanism of metronidazole-induced neurotoxicity.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Open iot service platform technology with semantic web

This paper centers around how innovations adds to enhancing interoperability between IoT gadgets, and making effectively utilization of IoT gadgets. The proposed stage innovation gives semantic-based IoT data administrations, and semantic interoperability of IoT gadgets. This administration stage can be material to a great deal of semantic IoT administrations: gathering imperceptible data in genuine condition by brilliant gadgets, giving keen life benefits by sharing, taking an interest, circulating open detecting data.

Dr H Shaheen Dr h shaheen

Deep learning techniques to improve radio resource management in vehicular communication network

This paper investigates the deep learning techniques to improve radio resource management (RRM) in vehicular communication network (VCN). In this paper, the deep learning algorithms are highlighted which are used for RRM. Deep learning technique in RRM is basically used to train the model using various algorithms of resource management including network data. Various machine learning tools will be helpful to get best solutions for resource allocation in a large cellular network.

Vartika agarwal Vartika agarwal

Near infra red spectroscopic analysis of macrotyloma uniflorum (lam.) verdc., phaseolus lunatus linn. and phaseolus vulgaris linn.

The present study is designed to determine the types of secondary metabolites in three selected seed powders using a fast, reliable, and non-destructive Near Infra Red spectroscopic analytical technique. NIRS analysis of Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn., and Phaseolus vulgaris Linn., seed flours were used to qualitatively evaluate secondary metabolites. The fine powder of crude drug was directly applied to FOSS XDS near the infrared Rapid Content Analyzer. The adequately filled powdered sample in a disposable glass silicate vial closed with a plastic lid was centrally placed onto the Foss Rapid Content Analyzer sample presentation glass. The scanning of samples at ambient temperature gives NIR spectra within 30 seconds. The major proposed compounds in M. uniflorum were 3,4-dihydroxybenzoic acid, caffeic acid, chlorogenic acid, ferulic acid, gallic acid, kaempferol, linolenic acid, niacin, quercetin, sinapinic acid, syringic acid, and vanillic acid. Whereas coumaric acid, fructose, galactose, L-serine, raffinose, stachyose, sucrose, threonine, and tyrosine were detected in P. lunatus, and the NIR suggested the presence of caffeic acid, ferulic acid, sinapinic acid, phytic acid, leucine, and valine in P. vulgaris. NIRS is an advanced innovative technology extensively used in chemical, food, petrochemical, and pharmaceutical industries for rapid and reliable standardization. The present study revealed an excellent correlation to conclude that flour samples of all three legume seeds could be added to the food system to achieve nutritional and functional benefits.

Dr. Salman Ahmed Dr. salman ahmed

Morphological and chemical traits associated with resistance against spotted pod borer, maruca vitrata in pigeonpea

Host plant resistance is an important tool for minimizing the losses in pigeonpea due to spotted pod borer, Maruca vitrata, which is the most threatening hidden pest of pigeonpea crop. Experiment was carried out to study the morphological and chemical traits in pigeonpea associated with expression of resistance to M. vitrata and their incidence in different sowing dates. The incidence of M. vitrata varied significantly among different sowing dates. Crop sown on D2 (1st week of July) resulted in maximum pod infestation by M. vitrata (13.1%). Minimum pod infestation (2.3%) and (2.9%) was recorded in D4 (3rd week of July) and D1 (3rd week of June) sown crop, respectively. Among different varieties, AL-201 registered lowest pod infestation (4.3%) as compared to Pusa-992 (7.9%). The non-glandular (type A), and glandular (type B) pod trichome density of top, middle and lower canopy of the plant and the pod wall thickness was responsible for the resistance to M. vitrata. Whereas, non-glandular (type C) pod trichomes, pod length, seed width and number of seeds per pod were associated with the susceptibility to spotted pod borer. Expression of resistance to M. vitrata pod infestation was associated with low amounts of crude protein and total soluble sugar and higher amount of fat content, phenol content and tannin content of seed as well as pod wall

DR. BABU LAL JAT Dr. babu lal jat

Two-phase flow in microfluidic-chip design of hydrodynamic filtration for cell particle sorting

As one of the flow-based passive sorting, the hydrodynamic filtration using a microfluidic-chip has shown to effectively separate into different sizes of subpopulations from cell or particle suspensions. Its model framework involving two-phase Newtonian or generalized Newtonian fluid (GNF) was developed, by performing the complete analysis of laminar flow and complicated networks of main and multiple branch channels. To predict rigorously what occurs in flow fields, we estimated pressure drop, velocity profile, and the ratio of the flow fraction at each branch point, in which the analytical model was validated with numerical flow simulations. As a model fluid of the GNF, polysaccharide solution based on Carreau type was examined. The objective parameters aiming practical channel design include the number of the branches and the length of narrow section of each branch for arbitrary conditions. The flow fraction and the number of branches are distinctly affected by the viscosity ratio between feed and side flows. As the side flow becomes more viscous, the flow fraction increases but the number of branches decreases, which enables a compact chip designed with fewer branches being operated under the same throughput. Hence, our rational design analysis indicates the significance of constitutive properties of each stream.

Myung-suk chun

Knowledge and attitudes regarding topical misuse of corticosteroids in libya

Prescription drug misuse has emerged as a significant problem over the past decade, particularly topical corticosteroids for skin lightening. This study aimed to assess the misuse of topical corticosteroids among the female population in southern Libya; to determine prevalence, awareness, attitude, and practice regarding this drug misuse. A descriptive, cross-sectional questionnaire was distributed on January 2022 to females aged between 16-45 years old in southern Libya. Out of 200 distributed questionnaires, 155 were returned with a response rate of 77.5%. The majority of the participants were aged 16-25 years (n=138, 89.0%) and over two-thirds of participants, said they obtained lightening products containing cortisone from pharmacies (n=107, 69.0%) while 36 participants indicated they obtained these products from cosmetic shops (23.2%). More than three-quarters of the participants said they were aware that they should read product ingredients (n=120, 77.4%). Just over one-quarter of respondents indicated they used the product on their face almost daily (n=41, 26.5%) while 28 participants denied using it (18.1%). The most common source of information about topical corticosteroids among participants was the Internet (n=51, 32.9%), followed by dermatologists (n=41, 26.5%), and pharmacists (n=31, 20.0%). Almost half of respondents were aware that topical corticosteroids can cause harmful effects (n=75, 48.4%). The most common indications reported for using topical corticosteroids were whitening (23.3%), and acne treatment (54.2%). Over two-thirds of participants, declared they would not use topical lightening products if they contained corticosteroids (n=107, 69.0%). In a similar attitude, nearly a third of participants stated that they would never use corticosteroid medications again if they knew about the negative effects of whitening (n=51, 32.9%). The majority of females, (87.7%), concur that only pharmacies should be able to sell and prescribe topical corticosteroid medications. The study's findings indicate that topical corticosteroids are frequently misused and that to lessen contraindications, especially for prolonged use, it is imperative to provide basic care to females who continue using topical corticosteroids in public or unlicensed marketing settings.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Clinical pharmacist in competition with medication errors in the neonatal intensive care unit

A medication error is any preventable event that may cause or lead to inappropriate use of drugs or patient harm if it is not under the control of the health care professional. Despite the fact that healthcare professionals take the responsibility very seriously, it has been estimated that 250 000 Americans die annually due to medication errors. Although, estimates show that one in ten patients worldwide is affected by medication errors while receiving hospital care, the harm can be caused by a range of incidents or adverse events. The exact incidence of medication errors in the neonatal intensive care unit (NICU) is unknown. In neonates especially premature infants, the immaturity of developing body systems affects the absorption, distribution, metabolism and excretion of drugs and therefore an exponential risk for medication errors is present. The risk of medication errors in children are much greater than adults.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Robotic-assisted inguinal hernia repair: a historical review

Inguinal hernia repair is one of the most common procedures performed in general surgery. Approximately 20 million hernia surgeries are performed every year worldwide. Conventionally, hernial repair is carried out with the open Lichtenstein technique; however, laparoscopic and robotic inguinal hernia repairs have been developed as a minimally invasive alternative to the classic Lichtenstein repair. The prosthetic mesh can be placed by totally extraperitoneal and transabdominal pre-peritoneal approaches. Choosing the best technique for repairing an inguinal hernia is a challenge because the available data are contradictory. However, a growing number of studies have claimed that robotic-assisted hernia repair is not only feasible and safe, but it is associated with outcomes that are comparable to those obtained with laparoscopy and open surgery, including shorter hospital stay, and fewer complications. The aim of the review article is to provide an overview of the current practice of inguinal hernia repair, with a focus on the advances in robotic-assisted inguinal hernia repair, as well as the advantages and disadvantages of this surgical procedure compared to the laparoscopic technique in view of the current reports in the literature.

Karishma Karishma

Medicinal plants with non-steroidal anti-inflammatory-like activity

Inflammation is a natural aspect of the immune system's response. Pain, redness, heat or warmth, and swelling are the four major symptoms of inflammation. Plants can generate a vast range of phytochemical substances as secondary metabolites, all of which have anti-inflammatory properties. Herbal medicines are significant cures for the treatment of a variety of disorders around the world. Medicinal plants are made up of roughly 7500 species, with representatives from about 17,000 higher flowering plant species. Even when synthetic chemistry has advanced beyond expectations, the utilization of natural products in the production of medications utilized in modern medicine is unrivalled. Anti-inflammatory medicines can help to reduce tissue damage and improve patient comfort by interfering with the pathophysiology of inflammation. As a result of the huge number of species available for investigation, the effective creation of new naturally occurring anti-inflammatory medications relies mostly on a multidisciplinary approach to finding new compounds. Despite the fact that many review articles have been written in this area, the vast majority of them only looked at the subject from a regional perspective. Various non-steroidal anti-inflammatory medicines have been proven to alleviate pain and inflammation by inhibiting the isoform of cyclooxygenase enzyme's digestion of arachidonic acid, hence lowering prostaglandin synthesis. Non-steroidal anti-inflammatory medicines come with a slew of negative side effects. Thus, there are, however, medicinal herbs that have anti-inflammatory therapeutic properties with a little or no negative side effects.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Implementasi pembelajaran fiqih materi sholat dengan media audio visual di madrasah ibtidaiyah

This research was conducted to form students to be more disciplined in maintaining time, especially in prayer, as well as to strengthen aqidah and increase the worship of students of Madrasah Ibtidaiyah Salafiyah Syafi'iyah. The focus of this research is: 1) How to plan the prayer chapter of fiqh learning through audio-visual media for students of Class IV Madrasah Ibtidaiyah Salafiyah Syafi'iyah Ajung, 2) How to implement the prayer chapter of fiqh learning through audio-visual methods for students of Class IV Madrasa Ibtidaiyah Salafiyah Syafi 'iyah Ajung, 3) How is the evaluation of fiqh learning in the prayer chapter for fourth grade students of Madrasah Ibtidaiyah Salafiyah Syafi'iyah Ajung. This research uses qualitative research with descriptive qualitative research. Determination of research subjects in this study was carried out purposively. Data collection techniques used observation, interviews, and documentation. Analysis of the data, the researcher used the data analysis model of the Miles, Huberman, and Saldana models including: Data Condensation (Condensation), Data Presentation (Display), Conclusions Drawing. The validity of the data in this study used source triangulation and technical triangulation. The results showed that: 1) The use of audiovisual media was very relevant in learning fiqh in the prayer chapter 2) Active, innovative, creative, effective and fun learning made students enthusiastic and enthusiastic in learning and not boring. 3) the completeness of learning facilities and infrastructure is very influential in the evaluation stage including summative evaluation and formative evaluation, input evaluation, process evaluation and output evaluation. Penelitian ini dilakukan untuk membentuk peserta didik lebih disiplin dalam menjaga waktu khususnya dalam shalat, serta memantapkan aqidah dan meningkatkan ibadah peserta didik Madrasah Ibtidaiyah Salafiyah Syafi’iyah. Fokus penelitianini adalah: 1) Bagaimana Perencanaan Pembelajaran fiqih bab sholat melalui media audio visual bagi peserta didik Kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung, 2) Bagaimana Pelaksanaan pembelajaran fiqih bab sholat melalui metode audio visual bagi peserta didik Kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung, 3) Bagaimana evaluasi pembelajaran fiqih bab sholat bagi peserta didik kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung. Penelitian ini menggunakan penelitian kualitatif dengan jenis penelitian kualitatif deskriptif. Penentuan subyek penelitian dalam penelitian ini dilakukan secara purposive.Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data, peneliti menggunakan model analisis data model Miles, Huberman, dan Saldana meliputi: Kondensasi Data (Condensation), Penyajian Data (Display), Penarikan Kesimpulan (Conclusions Drawing). Keabsahan data dalam penelitian ini menggunakan triangulasi sumber dan triangulasi teknik.Hasil penelitian menunjukkan, bahwa: 1) Penggunaan media audiovisual sangat relevan dalam pembelajaran fiqih bab sholat 2) Pembelajaran aktif, inovatif, kreatif, efektif, dan menyenangkan membuat peserta didik semangat dan antusias dalam belajar serta tidak membosankan. 3) kelengkapan sarana dan prasarana pembelajaran sangat berpengaruh pada tahap evaluasi meliputi evaluasi Sumatif dan evaluasi Formatif evaluasi input, evaluasi proses dan evaluasi output.

EDUCARE: Journal of Primary Education Educare: journal of primary education

Budd-chiari syndrome in gaucher disease type iii in an adult libyan male: letter to the editor

Gaucher Disease (GD) is the most common lysosomal storage disorder. The prevalence of GD is approximately 1/100,000, and type III GD accounts for 5% of cases. [1] It is an autosomal recessive disease due to a GBA gene mutation, leading to glucocerebrosidase enzyme deficiency. [1,2] Gaucher disease (GD) is categorized into three types according to clinical presentation: [3] Type I, which is non-neuronopathic and most common, particularly among Ashkenazi Jews; Type II, which is acute neuronopathic and marked by significant neurological involvement and high mortality rates; and Type III, which is subacute neuronopathic, exhibiting both systemic and neurological symptoms. In this report, we discuss a 24-year-old man from Libya diagnosed with GD type III. His diagnosis was established at the age of one due to symptoms including pallor, poor appetite, and hepatosplenomegaly. Laboratory tests indicated a hemoglobin level of 5.6 g/dL, chitotriosidase activity of 18,742 μmol/L, and an angiotensin-converting enzyme level of 251 UI/L. Genetic analysis confirmed a homozygous L444P mutation. He underwent splenectomy at the age of three, and enzyme replacement therapy (ERT) was administered intermittently with regular follow-ups until 2011. In December 2023, the patient experienced two weeks of abdominal pain, distension, and fatigue. A physical examination revealed ascites, dilated abdominal veins, and an enlarged liver and spleen.

Karishma Karishma

Medical research: a general perspective

Medical research is defined as "all scholarly activities that deal with any of the areas of studies being conducted in the pre, para, and clinical areas being taught in a medical school". Such a definition is somewhat arbitrary, as medical research covers a much larger field and ultimately affects every individual. The results of research activities are directly translated into social action, such as pollution control, vaccinations, mass fluoridation and nutritional improvements. The eradication of diseases like smallpox, poliomyelitis and plague, the decline in the death rate from infectious and cardiovascular diseases, and the diagnosis of genetic disorders are some examples of how medical research helps to provide improved health care. Thus, the wealth of medical knowledge that grows through the process of discovery and research development becomes part of daily living. The aim of scientific research is always to extend the frontiers of knowledge and to discover rational correlations and principles [1, 2]. Medical research can be divided into biomedical (basic medical), clinical, and health science research. The areas overlap each other and health science research has a component of social research. Experimental research covers areas such as physiology, biochemistry, microbiology, pharmacology and pathology and is relatively easy to conduct. If adequate financial support is obtained, the necessary infrastructure for laboratory research could be built and experimental animals maintained in an animal house. For clinical research, the patients with a particular disease are the direct object of study. This type of research involves dealing with the clinical picture, diagnosis, therapy and prognosis of the disease. Dealing with human beings requires stringent regulations and precautions to be observed. It requires setting up a research team in the hospital to monitor and chart out guidelines involving the ethical dimension of the problem to be studied and maintain a systematic medical recording system. Moreover, it is through a prolonged study of a large number of cases of the same disease that clinical research learns to predict the likely prognosis and judge the efficacy of the treatment. This type of research activity has limitations in the form of having a restricted number of cases of the disease under investigation, a need to update one's knowledge concerning laboratory techniques from which he obtains his 'cues', and the longer time interval required to complete the work. Health science research is a recent development of medical research due to the demands placed on many health services. More often basic medical and clinical research go hand in hand and are inseparable. Furthermore, clinical research workers often conduct studies on experimental animals, due to either the limited number of human cases or for ethical considerations.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Vesical explosion during transurethral resection of prostate: a dreadful complication associated with common endoscopic procedure

Vesical explosion during transurethral resection of the prostate (TURP) is an extremely rare, serious and dreadful complication, which should be considered as a blast injury requiring urgent exploratory laparotomy and repair. Until 2019, only 38 cases have been reportedin the International English literature. The underlying mechanism for this rare intravesical explosion is the generation and trapping of explosive gases under the dome of the bladder, which eventually detonates by sparks from the cutting electrode during TURP. Herein, we repor0low-up. Although uncommon, vesical explosion during TURP may occur and some preventive measures, discussed here, can be carried out to avoid this dreadful complication. In addition to the discussion of its mechanism, we will discuss the preventive measures of this dreadful event. To the best of our knowledge, this is the first case of a vesical explosion reported in our department.

Karishma Karishma

Student satisfaction with placement for internship in management study program

Internship activities are carried out in universities to introduce the working world to students in the future. This is important to be examined, especially in terms of the effectiveness of the program that has been implemented. By conducting a survey of students who have undergone the internship process, a clearer picture can be obtained of overall student satisfaction in response to the placement process during the internship. There are five factors emerge from the data analysis, namely interpersonal skills, work environment, culture, challenges, and benefit.

L L

N-gram and k-nearest neighbour based igbo text classification model

The evolution in Information Technology has gone a long way of bringing Igbo, one of the major Nigerian languages evolved. Some online service providers report news, publish articles and search with this language. The advancement will likely result to generation of huge textual data in the language, that needs to be organized, managed and classified efficiently for easy information access, extraction and retrieval by the end users. This work presents an enhanced model for Igbo text classification. The classification was based on N-gram and K-Nearest Neighbour techniques. Considering the peculiarities in Igbo language, N-gram model was adopted for the text representation. The text was represented with Unigram, Bigram and Trigram techniques. The classification of the represented text was done using the K-Nearest Neighbour technique. The model is implemented with the Python programming language together with the tools from Natural Language Toolkit (NLTK). The evaluation of the Igbo text classification system performance was done by calculating the recall, precision and F1-measure on N-gram represented text. The result shows text classification on bigram represented Igbo text has highest degree of exactness (precision); trigram has the lowest level of precision and result obtained with the three N-gram techniques has the same level of completeness (recall). Bigram text representation technique is extremely recommended for any text-based system in Igbo. This model can be adopted in text analysis, text mining, information retrieval, natural language processing and any intelligent text-based system in the language.

Dr. Nkechi Ifeanyi-Reuben Dr. nkechi ifeanyi-reuben

Potential of pharmacological and herbal for covid-19: a narrative review

The pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs in the prevention and treatment process. At present, there is no proven therapy for this disease, although therapeutic approaches continue to be carried out using traditional medicines (herbal) and pharmacological therapy. Information about SARS-CoV-2 virology has rapidly developed and scientists try to provide a number of potential drugs. Remdesivir has strong in vitro activity against SARS-CoV-2. Several potential drugs are currently underway in a clinical trial. Chloroquine, hydroxychloroquine, and oseltamivir have not been proven to have efficacy, and the benefits of corticosteroids are still diverse. Current clinical evidence does not support the termination of angiotensin-converting enzyme 2 (ACE2) inhibitors or angiotensin receptor blockers, coagulation therapy in patients with COVID-19 concomitant with comorbidities.

Syahrul Tuba Syahrul tuba

Compressive strength and durability properties of m35 grade concrete by replacing sand partially with vermiculite and granite powder and coarse aggregate by re-cycled aggregate

The Construction Industry is one of the industries contributing highest GDP in Indian economy. The material that is most chosen in construction Industry is concrete. Concrete is a material made with Cement, Fine aggregate in the form of sand, Coarse aggregate in the form of gravel and water. With increasing scarcity of sand, construction works are coming to jolt and thereby increasing the need for choosing an alternative material. Vermiculite is a material which after exfoliation can be used as a filler material replacing sand partially without affecting strength much. One more material Granite (by product which is a waste is causing lot of environmental Issues), produced from granite industry, is available in India in several million tons. Coarse aggregate generally used is a crushed aggregate obtained from rocks like granite, basalt and soon. Recycled aggregate is an aggregate which is obtained after demolishing of an existing building, which is a waste causing economical in balance and which if put into use can not only decrease the construction cost but also make this waste into a better use. In the present study, for a M35 grade of concrete, Vermiculite (0, 5%, 10% and 15% of weight of sand) and granite powder (fixed at 10% of weight of sand used) is used to replace sand partially and in the place of normal coarse aggregate, recycled aggregate is used which is 20 mm passing and 12 mm retained After preparation of Mix-Design(1:1.83:2.69 with w/c ratio of 0.38) the concrete cubes are casted to test for compressive strength after curing for 28 days, 56 days and 90 days. Forsec brand super plasticizer is used to take care of workability requirements. Durability test in the form of resistance to attack of sulphuric acid was conducted along with compressive strength. The test results were promising at 10% replacement levels of Vermiculite.

Kiran kumar narasimhan

Penanaman nilai-nilai pendidikan agama islam pada masa pandemi covid-19 di madrasah ibtidaiyah

The inculcation of Islamic religious values ??is an effort to shape the character of students to achieve a degree as a human being who is in accordance with norms, culture and religion. This research describes the process of internalization and the method of cultivating Islamic religious values ??in an unusual situation, namely in the era of the Covid-19 pandemic. In this study, researchers used a qualitative approach, a type of case study with interview and observation data collection techniques. The results of this study indicate that the implementation of student learning in a pandemic situation is carried out in two ways, namely (1) online and (2) offline. The values ??instilled in students include (a) worship, (b) faith and (c) morals. Meanwhile, the methods used by teachers in the process of inculcating Islamic religious values ??during the pandemic were practice methods, guidance methods, and memorization methods. Penanaman nilai-nilai agama Islam merupakan sebuah upaya dalam membentuk karakter siswa untuk mencapai derajat sebagai manusia yang sesuai norma, budaya serta agama. penelitian ini mendeskripsikan proses internalisasi hingga metode penanaman nilai-nilai agama Islam di situasi yang tidak biasa yakni di era pandemi covid-19. Dalam penelitian ini, peneliti menggunakan pendekatan kualitatif, jenis studi kasus dengan teknik pengumpulan data wawancara dan observasi. Hasil dari penelitian ini menunjukkan bahwa pelaksanaan pembelajaran siswa dalam situasi pandemi dilakukan dengan dua cara yakni (1) daring dan (2) luring. Nilai-nilai yang ditanamkan kepada siswa meliputi (a) ibadah, (b) keimanan dan (c) akhlak. Sedangkan metode-metode yang digunakan guru dalam proses penanaman nilai-nilai agama Islam selama pandemi adalah metode praktik, metode bimbingan, dan metode hafalan.

EDUCARE: Journal of Primary Education Educare: journal of primary education

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