The current study was designed to explore the antiemetic effect of the methanolic extract of Tithonia diversifolia (Hemsl.) A. Gray., leaves using chick emesis model to validate their folk use in G.I. disorders. Emesis was induced by the oral administration of copper sulfate 50mg/kg body weight to male chicks of four days of age. The antiemetic activity was determined by calculating the mean decrease in the number of retching compared to the control. Tithonia diversifolia leaves extract (150 mg/kg orally) showed a significant (p <0.05) antiemetic effect and was compared with the reference drug chlorpromazine.

Dr. salman ahmed

Climate variability also has the potential to worsen existing vulnerabilities such as Malaria, HIV/AIDS and Tuberculosis. This study examined the effects of poverty diseases and adaptive capacities to climate change on farm income along river Niger in Edo and Kogi States, Nigeria. Questionnaires were collected from 358 respondents using multistage sampling techniques from Edo and Kogi States. Descriptive statistics and different functional forms of ordinary least squares (OLS) were used as analytical tools. The results revealed that increase in farm size and age will lead to 1.27% and 1.83% increase in farmers’ income respectively. The major constraints identified by the respondents were lack of funds and credit challenge (94.40%), distance to health centres (93.90%) and access to freshwater supplies (82.70%). It was concluded that the majority 83.80% of respondents had malaria diseases. The study recommends that to reduce the effect of poverty disease, there is a need for policy makers to engage communities when making decisions relating to their health.

Sylvester ekemhonye

OBJECTIVE Study was designed to assess sexual experience, thoughts, and problems of women who have been treated with pelvic radiotherapy for cervical cancer. METHODS Seventeen sexually active patients who received minimum 3-month course of pelvic radiotherapy between March 20, 2014 and June 20, 2014 gave consent to participate in the study. Sexual life before cancer diagnosis and effects of treatment on sexual life were assessed with semi-configured score scale created by research group. RESULTS Main diagnostic finding was post-coital and post-menopausal bleeding, and vaginal stricture, vaginal dryness, and decreased sexual desire in partner or patient were primary sexual problems reported. CONCLUSION Health professionals should be aware of these effects and should encourage patients to express their problems and provide effective, individual counsel to each patient.

Reyhan aydin doğan

Alternative Learning System (ALS) has been adopted in Philippine basic education, yet there is no academic institution in the region prepares ALS teachers in teaching life skills. ALS teachers graduated from different programs of teacher education for formal education. In response, an extension project was conceptualized and implemented to enhance the teaching capacity and effectiveness of ALS teachers. Case study was conducted to evaluate the effectiveness of the project. It explored the transfer of life skills among ALS teachers. Data were collected from multiple sources. Interview and written responses, and feedback were analyzed using thematic narrative analysis. Other data were analyzed using document and descriptive analyses. The project had achieved its objectives and rated best by participants. These indicate that the project was implemented effectively and successfully. ALS teachers have acquired life skills and transferred them to others. Thus, the project has made a difference in the lives of these teachers.

Manuel caingcoy

This proposed work is used to optimize the costs of exceptional elements of machine cells for a variety of components in changing environments to have reduced material movements in cell layout. The exceptional ele¬ments are eliminated in the optimization model by doing machine duplication and part subcontract. Then the shop floor layout is designed to have optimized material movements between cells and within a cell. The result of a linear programming optimization model is cost savings, machines duplicated, parts subcon¬tracted, inter intracellular movements. Finally, the output of the inbound facility design is the floor layout which has machine cell clusters with optimized floor areas. The optimization model is provided with budg¬etary constraints for duplication and the economic tradeoff between machine duplication and part subcontract. Cell layout is prepared to reveal the saving in floor area and material movement lengths than in process layout with the help of distance matrix and dimensions of cells.

S ramesh

Background: Idiopathic Parkinson's disease (PD) is a central nervous system degenerative disorder with an unknown etiology. PD is the second leading cause of neurological impairments. Exercise therapy treatment is commonly used for PD to improve health and decrease the functional limitations. Exercise therapy includes Strengthening, aerobic, agility etc.. Objective: To investigate the evidence on efcacy and limits of strength training in rehabilitation of Parkinson's disease Method: A comprehensive search on pubmed, clinical keys database using keywords Parkinson's disease, physical therapy, strength training ,resistance training. The studies including Randomized controlled trails and systematic reviews published since 2005 are reviewed. Results: 36 studies identied through database searching. 25 studies are excluded due to duplicates, irrelevance, based on titles, outcome diversity. 5 systemic reviews and Meta analysis, 6 RCT are included. Review and analysis of articles is going on Conclusion : The result of this review suggests that strength training program can be effective in people with mild and moderate parkinson's disease. It can improve functional independency with increased muscle strength, gait parameters, posture and balance, all of these positive role on participation and quality of life.

Nagarjuna narayanasetti

A burning sensation on eating spicy foods purportedly supports the role of capsaicin, an active component of chili peppers, in the etiology of oral submucous fibrosis (OSF). Although the mast cell mediators and activated P2X receptors induce a constant burning sensation through an ATP-dependent mechanism, it is the activation of the transient receptor potential vanilloid 1 (TRPV-1) receptor by capsaicin that aggravates it. The molecular basis for the burning pain in OSF is thus attributable to the activation of TRPV1. There is overwhelming evidence that confirms capsaicin has more of a protective role in attenuating fibrosis and is potentially therapeutic in reversing conditions linked to collagen accumulation. The activation of TRPV-1 by capsaicin increases intracellular calcium ([Ca2+]i), upregulates AMP-activated protein kinase (AMPK) and Sirtuin-1 (SIRT-1), to enrich endothelium-dependent vasodilation via endothelial nitric oxide synthase (eNOS). The induction of vasodilation induces antifibrotic effects by alleviating hypoxia. The antifibrotic effects of capsaicin are mediated through the upregulation of antioxidant enzymes, downregulation of inflammatory genes and suppression of new collagen fibril formation. Capsaicin also demonstrates an anticarcinogenic effect by upregulating the cytotoxic T cells and downregulating regulatory T cells through the inhibition of angiogenesis and promotion of apoptosis. Judicious administration of capsaicin with an appropriate delivery mechanism may have therapeutic benefits in reducing pain sensation, rendering antifibrotic effects, and preventing the malignant transformation of OSF. This paper provides an overview of the molecular basis of capsaicin and its therapeutic application as an antifibrotic and anticarcinogenic agent for the treatment of OSF

Mohit sharma

Ethanol and hexane extracts of the leaves and male flowers of Luffa cylindrica were evaluated for antiemetic and anti-inflammatory effects using chick emesis model and carrageenan-induced rat paw oedema. The antiemetic effect was observed at 150 mg/kg body weight, whereas the anti-inflammatory effect was observed at doses of 500,750 and 1000 mg/kg body weight orally. Chlorpromazine 150 mg/kg and indomethacin 10mg/kg orally were used as standard antiemetic and anti-inflammatory drugs. The antiemetic effect was determined by calculating the mean decrease in the number of retching compared to the control group after 10 minutes of copper sulfate (50 mg/kg orally) administration. The degree of paw oedema of all the groups was measured using a plethysmometer at the 5th hour of carrageenan (1% w/v) administration. All extracts except hexane extract of leaves exhibited statistically significant (P<0.001) antiemetic and except hexane extract of flower, all extracts exhibited statistically significant (P<0.05) anti-inflammatory effects.

Dr. salman ahmed

Plant secondary metabolites refer to various chemical compounds that plants produce. Still, they are not directly involved in essential growth processes like primary metabolites (such as sugars, amino acids, and lipids). The term "secondary metabolite" has generated controversy, as it implies these compounds are of minor importance to plants. "Special metabolites" may be a more suitable term. These metabolites protect plants from both abiotic and biotic stress. The vast diversity of plant secondary metabolites showcases plants' incredible adaptability and versatility, providing an arsenal of chemical tools to defend against herbivores, protect from pathogens, attract pollinators and seed dispersers, adaptability and thrive in environmental interactions. Plants can, therefore, survive under less-than-ideal conditions. The profound impact of plant secondary metabolites highlights the intricate relationship between plants and humanity, opening doors to innovative applications with far-reaching implications.

Dr. salman ahmed

Lexical and structural levels of language abound ambiguities that are good source of humor. Consequently, violations of the maxims of conversation are leeway to induce humor in any type of discourse. Adding these two precepts and considering pragmatics as its foundation became the bases in analysing the top-grossing films of Vice Ganda. It sought to identify the verbal linguistic jokes and ambiguities present in the top-grossing films of Vice Ganda; determine on how these ambiguities create devaluation of Grice’s maxims of conversation; and determine on how the ambiguities in verbal linguistic jokes and devaluation of Grice’s maxims of conversation were used as ingredients in Vice Ganda’s top-grossing films. Discourse analysis was used in the study and the analytical framework to induce humor by Taghiyev (2018) was used in analysing the corpora. A priori coding was used to identify the recurring ambiguities and devaluation of maxims in the films. Findings show that lexical-semantic and structural-syntactic ambiguities were present in the films. It was intentionally used in order to create humorous effect in the dialogues of the films. Moreover, the devaluation of the maxims of conversation quietly and unostentatiously, opting out, coping with a clash between maxims, and flouting was deemed an effective ingredient to make the films become comical and appealing to the audience.

Darrel ocampo

The main purpose of the research is to develop modern tools for insurance management in the global economic crisis, to make an objective assessment based on a critical analysis of existing ones, to identify situations that could lead to international economic, social and natural threats. It is made some recommendations for the development of insurance calculations for the republic of Uzbekistan. Methods: Methods for reforming modern calculation of insurance tariff are recommended by means of theories of probabilities, statistical and mathematical analysis, and foreign advanced countries practical types of summarizing. Findings: While making an analysis, it has found that modern tools for the insurance management of Uzbekistan are needed. We proved this by the results of the modern calculation of insurance in tables (1-6). For the development of the insurance market of Uzbekistan, it should be analyzed by means of penetration and density of insurance premiums, making the deepest calculation of risks of the economy of Uzbekistan, and using the main principals and formulas of the theory of probability. Conclusions: In the end, we can take some results, and give some recommendations such as using the tools of theories of probabilities can help us find the main risks of economy, its powers of influences of the market economy, statistical and mathematical analysis also add some practical, objective results for making under control of any types of insurance risks.

Ikboljon odashev mashrabjonovich

The study examined psychological predictors and mediators of teacher subjective well-being. Participants included 174 teachers from urban middle and highschools. The first objective was to explore the psychological correlates of the teacher SWB: self-esteem, general self-efficacy (core self-evaluation), teacher self-efficacy, optimism (cognitive trait related to the psychological well-being), and perceived social support (psychosocial trait related to the psychological wellbeing. The second objective was to investigate the mediating role of self-efficacy in the association between optimism and subjective well-being. The third objective was to explore the mediating role of teacher self-efficacy in the relation between perceived social support and teacher subjective well-being. Correlation, linear regression and mediation model analyses through the Sobel test were computed. Results confirmed the research assumptions. The findings of this study enhance the understanding of personal factors associated with teacher subjective wellbeing. The constructs linked to subjective well-being (predictors and mediators) could be target of school psychologists’ interventions, in order to have more engaged and performing teachers in schools. The findings were discussed in the context of designing the interventions for enhancement of the subjective wellbeing among teachers.

Elena stănculescu

Study objectives: The study aimed to evaluate the antitussive effect of aerial parts of ethanolic extract of Caesalpinia pulcherrima (Caesalpiniaceae). Methods: In this study, cough was induced by the sulfur dioxide induction method. Four groups of animals were made, with six animals in each group, and all drugs were administered orally. Group I was used as a control, group II as a standard, and groups III and IV received 200 and 400 mg/kg Caesalpinia pulcherrima aerial parts extract. Results: Caesalpinia pulcherrima aerial parts (CPAP) extract suppressed cough. Doses of 200 and 400 mg/kg Caesalpinia pulcherrima aerial parts extract showed highly significant results compared to the standard at 60 and 90 min of drug administration. Conclusion: From the above results, it can be concluded that plants have significant activity in cough suppression.

Dr. salman ahmed

Viral hepatitis is one of the main public health concerns around the world. Even though infection management techniques have been implemented over the last few decades, eradication or significant reduction has remained a mystery. The purpose of this study is to look into the prevalence of acute infectious hepatitis in the East of Libya and how the type of virus, age, gender, clinical manifestations, and outcome are related. This is a hospital-based retrospective study. The data on the frequency and distribution of viral hepatitis based on age, gender, seasonal, clinical, and ultrasound findings, and the outcomes during a period of two years from January 2020 to December 2021 were collected and analyzed. Of the 0.39% (72 cases) of total hospital admissions (18340) under the age of 15 years old for acute infectious hepatitis patients, the most common age group was 5-12 years (79.6%). Winter accounted for 41.6% of all the cases. Females made up 65.3% of the cases. Jaundice was the most prevalent presentation (87.5%). Hepatomegaly was seen in 83.3% of the patients. Most of the cases have mild hyperbilirubinemia (5-9 mg/dL, 75.0%). Approximately 1/5th of the patients' serum glutamic-oxaloacetic transaminase (SGPT), and nearly 1/3rd of the patients' SGPT levels were in the range of 1000-2000. One patient's hepatitis C was positive, one patient's hepatitis B was positive, and 97.2% were positive for hepatitis A. 88.8% of the individuals recovered without complications, whereas 11.1% showed symptoms of hepatic failure but recovered. The present study indicates that acute hepatitis A is more prevalent, especially in the winter. Those who are females and 5-12 years of age were more affected by acute viral hepatitis in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

Vitamin C causes a significant change in pharmacological effects of some drugs which may lead to unpredictable responses. Vitamin C-haloperidol interaction has not been confirmed in vivo. This study was aimed to investigate the influence of vitamin C on some pharmacological effects of haloperidol (extrapyramidal side effects caused by the antipsychotic haloperidol). Albino male mice (n = 24, body weight of 20 - 40 gm) were divided into four groups and each of consists of six mice. Group I (control): given 1% Tween 80 solution, group II: given vitamin C in a dose of 100 mg/kg, group III: given haloperidol (2 mg/kg), while group IV: given a combination of vitamin C and haloperidol. All the treatments were given by intraperitoneal route of administration. Three sub-acute doses of different treatments were given at 24:0, 5:0, 1:0 hour before scoring. Parameters scored were catalepsy, ptosis, rigidity and akinesia. The experiment was repeated using vitamin C in a dose of 500 mg/kg. Both doses of 100 and 500 mg/kg of vitamin C significantly antagonized the effect of haloperidol by decreasing all the tested parameters. The results indicate that vitamin C decreases extrapyramidal side effects caused by the antipsychotic haloperidol and show that it successfully decreases catalepsy, ptosis, rigidity and akinesia in mice.

Mediterranean journal of pharmacy and pharmaceutical sciences

The city that never sleeps, a vibrant tapestry of dense neighborhoods and relentless energy, has long grappled with the pervasive challenge of air pollution. The very dynamism that defines the city – its traffic, buildings, and industry – contributes to ambient concentrations of fine particulate matter (PM2.5) and ground-level ozone (O3), pollutants known to exact a heavy toll on public health. [1-3] An extended analysis of environmental health data from 2005 to 2019, meticulously compiled by the town Department of Health and Mental Hygiene (DOHMH), offers a crucial lens through which to view the city's journey: a narrative marked by significant public health victories interwoven with stark, persistent environmental injustices. [4] This fifteen-year period reveals not just the efficacy of targeted interventions but also the deeply entrenched disparities that continue to leave vulnerable communities uneasy. Thus, the aforementioned challenge provides a very important lesson to address similar problems around the globe, especially in the crowded urban areas.

Karishma

This paper examines Nigerian students’ perception or approach to libraries. It cuts across the primary, secondary and tertiary institutions. The reason for the laxity in library real time usage is the primary driving force that led to the research. The research method adopted for this study was longitudinal method to get the right place of the actual issues without official cover-ups where necessary. Secondary data were also used to buttress the position of the research. The population approached for the longitudinal method was randomly picked at the different levels of schools. Parents were also in place at some point to drive home the true intent they have about their children and the use of libraries. Findings revealed that seeming laxity of both undergraduate and graduate students’ perception and attitude about the library is primarily because of the lacuna in their other levels of education before coming to the university. This served as a useful yard stick for the researchers developing workable recommendations that in their opinion will be of immense help to solving it. Index Terms— Library Knowledge, Nigerian Student, Primary School Library, Secondary School Library, Tertiary Library.

Emmanuel musa

Potato starch extraction is a critical process with implications across various industries, including food, pharmaceuticals, and bioplastics. This review explores current techniques, challenges, and future opportunities in potato starch extraction. Traditional methods such as compression or wet grinding, enzymatic processes, and microwave-assisted extraction are examined for their efficiency, advantages, and limitations. The paper emphasizes the importance of quality control measures to ensure the purity and safety of the extracted starch. Critical quality control aspects include raw material inspection, monitoring during processing, purity and composition analysis, and adherence to national and international standards. Innovations in extraction methods, including enzymatic and green solvent extraction, ultrasonic and microwave-assisted techniques, and advancements in nanotechnology and biotechnological approaches, are highlighted as trends driving the industry towards greater sustainability and efficiency. The clean label movement also reflects a consumer-driven shift towards natural, minimally processed ingredients, influencing industry practices and regulatory compliance. The future of potato starch extraction holds significant promise, with the integration of sustainable practices and technological innovations to meet evolving market demands and regulatory standards, underscoring the need for continuous research and development in the field.

Dr. salman ahmed

Supply chain management, especially in manufacturing companies, is very important as the companies rely on the raw materials needed for production. Moreover, the success of a company is also determined by how it could gain competitive advantage to compete in the industry. It is proven that a company with effective supply chain management and competitive advantage would perform better. The purpose of this research is to see the effect of supply chain management and competitive advantage on company performance conducted at PT Ahlindo Perkasa Alam. This research uses quantitative method with Census sampling of 32 employees working in the company. The test results show that Supply Chain Management and Competitive Advantage have a positive significant effect on Company Performance at PT Ahlindo Perkasa Alam as much as 76.1%.

Lila maria kaban

Medicinal plants are the gift of nature and play an important role as a part of our diet to maintain health. They also serve as a versatile weapon to combat several diseases. Every civilization has its own experience and knowledge of the therapeutic uses of plants. The belief and observations regarding traditionally used medicinal plants increase people's interest in using them against urolithiasis. Urolithiasis is a common problem that has been afflicted for centuries and has a high recurrence. Of the world's population, about 12% suffer from urolithiasis. All over the world, in different countries and cultures, people use plants to prevent and cure kidney stones according to their ethnopharmacological information. These formulations are very effective. That's why they have been used for hundreds of years. This review covers the eighty (80) medicinal plants of the most cited family Asteraceae against urolithiasis and their historical antiurolithiatc background shared in well-known books of Dioscorides, Pliny the Elder, Al Razi and Ibn Sina. This information was extracted to compose antiurolithiatic plants with their parts and formulations used in 21 countries such as Algeria, America, Australia, China, India, Iran, Italy, Jordan, Jordan, Kyrgyzstan, Lebanon, Libya, Mexico, Morocco, Pakistan, Palestine, Philippine, Spain, Tunisia, Turkey and Uzbekistan. Scientifically proven pharmacological activities of the same part of the plant have direct (litholytic) and direct pharmacological effects like analgesic, anti-inflammatory, antioxidant, astringent, demulcent, diuretic, litholytic, lithotriptic, antiurolithiatic, antispasmodic, ACE inhibition and Phospholipase A2 inhibition also shared as a plausible mechanism of action. The route of administration is oral in all cases. Hopefully, this book will be useful for the general public and attract the scientific world for antiurolithiatic drug discovery. This valuable ethnopharmacological information will provide opportunities for the future research and development of new natural antiurolithiatic compounds.

Dr. salman ahmed