Creative tourism has been stimulated as new form of tourism by more skilled forms of tourism activities, by the growth of new consumption patterns, and by changes in the production of tourism products. It can solve that problems experienced by tourists in the conventional tourism. Creativity has many definitions and that based on the function of creativity, it was historically related to creative person, but the recent research in creativity focused on creative product. However, creativity can be located in four areas, and they are: creative person, creative product, creative process, and creative environment. Creativity means “the production of novel and useful ideas in any domain”, which refers to the generation of ideas. Today, creativity becomes as a strategy that promoting individual skill development and innovation, this strategy has been followed by many cities and regions around the world in order to obtain the growth throughout commodification, knowledge development, globalization and increasing competition. Creativity can play a significant role in the mainstream tourism experiences that can be added to the places’ atmosphere, creativity is considered as an attractive policy for stimulating other creative activities and outcomes of social, economic and cultural through spilling knowledge and networking. Indeed, creativity can impact tourism in many ways such as: tourism itself as a creative area, tourism products, skills development and performance development. Thus, the important role of creativity in tourism has been incarcerated in many trends

Mukhles m. al-ababneh

Solar Energy is the prime important source of energy, and it has continued to gain popularity globally. As of 2018, about 486 GW of solar PV was installed worldwide. One of the key requirements for socio-economic improvement in any nation of the world is the provision of dependable electricity supply systems. Recently, there is a massive growth in access to solar electricity in several Africa countries, notably South Africa, Egypt, Morocco, and Algeria. As a result, it decreases the global population without access to electricity with an appreciable value. This paper review the present state of solar energy capacity in the world also identifies vital approaches of improving their functionality, reliability, and affordability as well as the essential method that policymakers may implement in the future. The result shows that there is a recurrent growth in solar energy annually and as at the end of 2018 Asia with the largest capacity of 56.58%, while Central America and the Caribbean have the lowest installed capacity of 0.36%. As the request for an uninterrupted supply increases in different regions, progressive builders are embracing solar photovoltaics (PV) renewable energy as an option for their customers.

Najeem olawale adelakun

Accurate diagnosis of the cause of acute or chronic kidney dysfunction may require a percutaneous kidney biopsy (PKB). Unfortunately, the invasive nature of the procedure can lead to potential complications that may discourage the KBs. Lack of appropriate communication skills, experienced personnel and equipment, and high procedure costs can negatively impact complication rates and the frequency of conducted KBs. This nonsystematic review assesses KB procedures, indications, contraindications, complications, post-KB monitoring time, and cost. We looked for reviews and original articles published between January 2010 and Jan 2025 on Google, Google Scholar, and PubMed. Different keywords, phrases, and sentences include PKB, renal biopsy, native PKB, ultrasound guide, CT-guided, PKB, allograft PKB, and PKB procedures. KB makes histopathological and immunohistological diagnosis possible, which are necessary for diagnosis and treatment. It is often used despite the known complications. KB and other biochemical assays have tracked transplant rejection and antirejection drugs. Automatic gun spiral needles sizes 14 and 16 capture enough samples with fewer complications than gauge sizes 18 and 20. KB cost is another issue, especially in low-income areas, and deserves additional study.

Karishma

Long periods of free-movement Restrictions may negatively affect Cardio-Pulmonary fitness and health. As, the COVID-19 virus primarily affects Respiratory system, and also associated with cardiovascular disease, can induce the following complications like thrombosis, myocardities, Interstitial pulmonary fibrosis, diffuse alveolar damage and persistent decline in lung function, as the lung capacity decreases it may results in decrease in Cardio Pulmonary endurance. The Present study investigated changes after the COVID-19 confinement in total distance covered in 6 minutes by patients and correlation between 6 minutes walk test vs. oxygen saturation; Results suggest that the Mean ± SD of age is 43.4 ± 10.8years. Male: Female 1:0.5.Mean ± SD of total distance walked in 6 minutes by patients is 443.5 ± 55 compared with Hypothetical mean (normative value) is 571 ± 90.Correlation between Total distance walked in 6 minutes vs. oxygen saturation is r = 0.055.

Nagarjuna narayanasetti

Hemodialysis patients suffer from poor health-related quality of life which results in a higher risk of hospitalization and mortality. This study investigates the importance of pharmaceutical care and role of pharmacist for hemodialysis patients to optimize drug therapy, minimize drug related problems and thereby improving their health-related quality of life. The study was conducted to evaluate the impact of pharmaceutical care interventions on health-related quality of life of hemodialysis patients in Benghazi, Libya. Randomized control study was carried out after getting an ethical approval from the committee of the hospital. Health-related quality of life was assessed using SF-36 instrument for all the patients (n = 80). Among them, 40 patients were received the normal care along with brief medication review and counselled by pharmacists for two months. Then, health-related quality of life was assessed again for those 40 patients who received the pharmaceutical care. Data was analyzed using an appropriate methods. The results showed that the quality of life for hemodialysis patients was poor in both physical and emotional aspects. After implementation of appropriate pharmaceutical care to the patients, their quality of life improved significantly. Health-related quality of life is an important determinant of treatment effectiveness in dialysis patients

Mediterranean journal of pharmacy and pharmaceutical sciences

A huge number of embedded devices offer their services to the end users in pervasive environments. Context-aware discovery is a rich and very dynamic system extensively applied for combining the different mobile devices, sensors, actuators and software functions. Existing knowledge-based system using the Common KADS (CKADS) system represent contextual information but algorithm are not effective in predicting the user behavior. Current Location-aware Private Service Discovery (LPSD) considers the discovery path for reducing the distributed topology and flooding operations. LPSD in pervasive environment is not effective in accurately locating the required service by searching method. To present an architecture principle for accurately predicting the user behavior in mobile-pervasive computing environment, Affluent Context Aware Systems based on the User Behavior (ACAS-UB) is proposed in this paper. ACAS-UB mechanism contains the class of mobile devices that can sense (i.e.,) search the physical pervasive environment. Affluent means effectively engaged mobile devices in ACAS-UB mechanism which uses the context information. The ACAS-UB context information contains the judgment of the similar users and also the response from the other users for improving the effectiveness in pervasive environment user behavior prediction. Master-slave concept is used in the ACAS-UB mechanism for the easy collection of response information from the different users. ACAS-UB mechanism construct the user profile initially from the context information, then performs the similarity measure and finally work is to predict the user behavior. ACAS-UB mechanism provides the hints which are necessary to explore different options, rather than just limiting the options in mobile-pervasive computing environment. ACASUB mechanism is experimented on the factors such as message overhead in pervasive environment, scalability and approximately 10 % lesser processing time.

Dr h shaheen

Introduction: Study was conducted with an objective of investigating the inhibitory effect of Phaseolus lunatus seeds extract on three enzymes (α-amylase, maltase and glucoamylase) involved in diabetes. The disadvantages related to the use of synthetic drugs make it necessary to search for alternative medicines from medicinal plants. One therapeutic approach for treating postprandial hyperglycaemia is to decrease the plasma glucose level, which can be attained by lowering the starch hydrolysis by digestive enzymes such as α-amylase, maltase and glucoamylase. The use of synthetic antidiabetic agents caused gastrointestinal side effects. Methods: Hence, the research was aimed to evaluate the potential of Phaseolus lunatus seeds extract to inhibit α-amylase, maltase and glucoamylase as a possible mechanism of hypoglycemia caused by this plant with fewer side effects. Phaseolus lunatus, also known as Lima bean, is native to Tropical America and grown worldwide. Lima bean has been prescribed traditionally to treat different diseases, including diabetes. Result: The results of the present study showed that Phaseolus lunatus seeds extract has exerted both time and concentration-dependent Significant inhibitory effects on these digestive enzymes might be due to the cumulative impact of phytoconstituents in the plant extract. Conclusion: Therefore, it can be said that the part mechanisms by which Phaseolus lunatus exhibited its antidiabetic activity might be through inhibiting this digestive enzyme.

Dr. salman ahmed

The study employed Appreciative Inquiry framework to have an in-depth investigation in the personal lives of the participants and to draw connections between their beliefs and practices in taking Licensure Examination for Teachers and how these superstitions reflect and affect their moral principles. Specifically, it aimed to: (1) determine the superstitious beliefs followed by the examinees before, during, and after taking the Licensure Examination for Teachers (LET); (2) determine the positive and negative impact of these superstitions in the aspect of taking LET; and, (3) identify the effects of these superstitions in the characters and principles of the teachers. Semi-structured interview and focus group discussion were used and the data-sources were triangulated to come-up with a stronger analysis. Audit trail and member checking were followed to ensure that there were no biases in the interpretation of the data and to establish the validity of the results. Findings revealed that the student examinees followed different superstitious beliefs before, during and after the exam which have positive and negative effects. The motive of avoiding failure in the examination predominates over the motive of achieving success. The positive and negative effects of superstitions vary from one person's experience to another. Moreover, the assertion and personal disposition to pass the exam became the product of student examinees' projection. The superstitious notions were initiated to discard the student examinees' fears and to safeguard their emotional sphere against negative feelings and any untoward possibilities. Meanwhile, in the development of moral principle, the student examinees' family, peers and the society are important factors in the establishment of their belief system which later on reflects the moral principles they uphold.

Darrel ocampo

Background: Phaseolus vulgaris, commonly known as kidney bean, has been studied previously for pharmacological properties such as antidiabetic, antioxidant, analgesic, anti-inflammatory, antifungal, and antibacterial properties. Various extracts of the seeds have been researched except fixed oils. Objective: Therefore, the present study aims to investigate the behavioral activity of fixed oil extracted from Phaseolus vulgaris seeds. Methodology: Hole board, light and dark, stationary rod and open field tests were used for behavioral evaluation. Four groups were made with seven mice in each : (1) Control = Normal saline 2ml/kg (2) Phaseolus vulgaris fixed oil = PVFO 2ml/kg (3) PVFO 4ml/kg (4) Diazepam (1mg/kg) as standard. All treatments were given orally 30 minutes before the performance of tests. In the hole board test, PVFO 4ml/kg decreased the number of head poking (p≤0.01). Results: In light and dark tests, PVFO in both doses reduced the time spent in the light compartment (p≤0.01). In the open field test, the number of peripheral lines crossed was decreased (p≤0.05), whereas in the stationary rod test, no effect was observed by any dose of PVFO. Conclusion: Results indicate that Phaseolus vulgaris fixed oil does not affect memory or learning in mice and may possess a dose-dependent sedative hypnotic effect.

Dr. salman ahmed

Background: To assess the awareness, knowledge about refractive errors and strabismus among the general public in southern Indian states of Andhra Pradesh and Telangana. Methods: A cross sectional population-based survey used a semi structured questionnaire on awareness, knowledge on refractive errors and strabismus done as part of knowledge, attitude and practices study (KAP). Stratified multistage cluster random sampling method was used with a sample size of 867 adults- ≥16 years. Having heard of refractive error and strabismus was defined as awareness and having knowledge of the type of error for which spectacles were worn, was considered as knowledge. A pilot study was conducted to validate the questions used in the main study. Statistical package SPSS (version 19) was used for analysis to calculate logistic regression and odds ratios for gender, age, education and urban-rural areas. Results: A total of 782/867 (90.1%) subjects participated in the survey with females 47.4%. 581 subjects (74.3%) were aware of refractive error. 690 subjects (88.2%) were aware of squint. With multiple logistic regression about awareness of refractive error to various variables, subjects who were educated 11th class to degree had a higher awareness (OR: 2.40; CI: 1.25-4.60). With multiple logistic regression about awareness of squint to various variables, females had a higher awareness of squint (OR: 1.98; CI: 1.19-3.31). Conclusions: Awareness of squint and refractive error was high among the general public, but the knowledge of it was limited.

Srinivasa reddy pallerla

The Cellular Manufacturing is adopted in batch type manufacturing industries nowadays for their production with increased productivity, less cost and time with effective control. The proposed optimization model is used to determine the cost of machine cells, i.e., machine duplication, part subcontract, inter intra cellular movements cost and cost of production associated with machine cell, such as machine reconfiguration and part inventory considering machine flexibility for various time periods. Initially, mathematical model is proposed to calculate machine cell cost with and without considering machine flexibility and then another lpp integer model is proposed to calculate the machine cell production and associated cost for the changes in time period, part type and volume considering machine flexibility. The manufacturing data in the incidence matrix and machine cell, part family data in the block diagonal form are given as input to the optimization programming language Cplex and the output are given for the two mathematical models. The data related to machine duplication, part subcontract, inter intra cellular movement; machine reconfiguration and part inventory are given. Two dimensional shop floor layouts are presented in rectilinear coordinates for all the problems for easy analysis of material movement length and shop floor area

S ramesh

The rate of aging is rapidly increasing and the term of geriatric refers to offer a medical care to elderly people. Drug consumption study on geriatric population is a vital issue since this group is totally neglected in Libya. The aim of this study was to assess drug utilization pattern among elderly patients in terms of world health organization core prescribing indicators and to evaluate the treatment cost. A total of 106 prescriptions were randomly collected from different community pharmacies located in Tripoli during the summer 2019, and were evaluated (total number of prescribed drugs is 359) for their clinical efficacy and safety. The findings revealed that 60 drugs acting on GIT (16.7%), 50 antimicrobial drugs (13.9%), 31 antihypertensive drugs (8.6%) and 30 drugs for respiratory diseases (8.4%) were prescribed to patients who are 65 years old or more. With regard to disease pattern in the elderly Libyan patients, 27 drugs were prescribed for diabetes mellitus (7.5%), 24 drugs for cardiovascular drugs (6.7%) and 14 drugs for anti-hyperlipidemia (3.9%). According to the WHO core drug use indicator pattern, the average number of drugs prescribed per encounter was 3.3. Prescription by generic name was low (41.5%). Antibiotics were 36.8% while injections were 26.6%. Thus, this study suggest that geriatric medicine and rational drug use should strongly be implanted in medical schools and teaching hospitals. Besides, a drug pattern use of the Libyan community is urgently required to avoid drug prescribing errors.

Fathi m. sherif

Community pharmacist plays an essential role in educating the epileptic patients about their disease and medications. Improving the patient’s awareness may lead to improve their compliance and decrease drug-drug interaction and ultimately improve their quality of life. Pharmacist can detect the emergence of health problems and can help prevent progression of comorbidities. Considering the complexity of treating epilepsy and the lack of information about pharmacists’ contributions to epilepsy management, pharmacist performed pharmaceutical counselling, pharmaco-therapeutic follow-up and systematic measurement and evaluation of findings and increase medication adherence of patient with epilepsy. This study was aimed to assess the community pharmacist's knowledge about epilepsy and their treatment by antiepileptic drugs in Libya. The design of the study is a cross sectional study. The knowledge was collected through a questionnaire which included 35 questions divided into three sections: demographic data, general information about epilepsy and information about epilepsy and antiepileptic drugs. The questionnaire was prepared and validated by consultant training in Ali Omer Asker Hospital in Tripoli for two months. The findings indicate that over 200 patients are altered viewed, of whom, only epileptic patients were observed. The majority of the participants were female, qualification degree BSc and years of experience from one to five years. Unfortunately, some of the participants (40.0%) had poor knowledge and about 60.0% of them had good knowledge. This study indicates that the importance of community pharmacist in Libya requires more improvement to achieve the existing function and that the impact of continuous study of everything related to diseases and medicines is important to obtain a qualified pharmacist who can become an effective agent for a change.

Mediterranean journal of pharmacy and pharmaceutical sciences

Obesity is a complex and challenging global public health concern. It is a major disease involving excessive fat accumulation that may impair health. Obesity is dangerous and has been related to a range of long-term health issues that can impact adults and children. According to the World Health Organization, more than one billion people worldwide are obese as of March 2022. In the Libyan situation, the prevalence of obesity has increased among the public over the last decade. This cross-sectional survey-based study is conducted by using self-structured designed questionnaire to evaluate the use of anti-obesity drugs and herbal products among Libyan people. Additionally, considered as an indirect method, pharmacist performance in obesity management was also evaluated. The investigators collected interview data from three different cities in the Northwest of Libya over a period of five months, 2019. A total of 170 participants who use weight loss products were randomly selected to participate in the study after obtaining their verbal consent. The participants' experience with weight reduction agents revealed that more than half of the participants (52.3%) used herbal products while 32.0% of the participants have used drugs of chemical origin and 15.6% have used both (herbal and drugs). The majority of the participants (91.4%) used these products without medical consultation which in turn led to failure to lose and maintain weight with 74.2% gaining weight after stopping using these products. In conclusion, poor pharmacist intervention in obesity management was revealed where the majority of the participants reported that Libyan community pharmacists had not been offering weight management services, monitoring weight loss progress, or explaining the risks of being overweight or obese.

Mediterranean journal of pharmacy and pharmaceutical sciences

A Novel route one-pot three-component reaction was developed for the synthesis of 2,3-Dihydro-2-phenyl-1- H-Naphtho-[1,2-e] [1,3] Oxazine by using Substituted Aniline, Formalin & β-Naphthol in the presence of Tannic acid (10 Mol %) as catalyst. The reaction is observed by using TLC, after completion of reaction product is characterized by 1H, NMR, 13C NMR, IR and Mass Spectra.

Dr.prashant kumdale

Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .

Dr ganesh n yallappa

Emesis is defined as a forceful expulsion of stomach contents via the mouth. The adverse effects of available anti-emetic drugs potentiate us to evaluate natural products to explore effective natural anti-emetics with fewer side effects. The fruits of Illicium verum Hook. f. were selected for anti-emetic activity based on their folkloric use against gastrointestinal complaints. Crude methanolic extract and its aqueous, dichloromethane, ethylacetate and hexane fractions were evaluated using the copper sulphate-induced chick emesis model. Emesis was induced by the oral administration of copper sulfate 10 ml/kg body weight and metoclopramide (150 mg/kg p.o.) as a standard anti-emetic drug. The anti-emetic effect was observed by calculating the mean decrease in the number of retches compared to that of the control. Methanolic extract and its fractions were tested at 25, 50 and 75 mg/kg oral doses. Among all tested fractions, ethyl acetate showed the highest (94.46%), and hexane showed the lowest (56.30%) anti-emetic activity at 50 mg/kg. Further, isolation and purification from the same fractions are in process to discover effective natural anti-emetic compound(s) with less unwanted effects.

Dr. salman ahmed

Vending on the street is a worldwide fact and the most able to be seen component of the casual economy. Street vending, like other informal sectors, is characterised by low pay, ease of entrance, self-employment, and a huge number of individuals. Millions of individuals make a livelihood selling a variety of products and services on the street in cities and towns all over the globe. Despite the popular assumption that street selling would decline as the economy improves and wealth rises, it is on the rise in many areas. Because of their poor level of education and abilities, street sellers are often individuals who are not capable to get usual employment in the remunerative recognized sector. They attempt to address their financial issues by relying on their own limited financial resources. They are primary sharing route for a wide range of the daily-use goods, such as fruits, vegetables, ready-to-wear clothes, home appliances, stationery, toys, newspapers, magazines and shoes among others. If they be removed from the urban marketplaces, it would create serious problem for vegetable and fruit growers and small-scale businesses that couldn't afford to sell their goods via the formal sector's costly distribution networks. The significance of this industry can not be overstated, particularly given the government's inability to offer employment to India's millions of jobless and underemployed citizens. Even the corporate sector can only absorb a small part of our growing workforce. Overall, employment in the official sector is decreasing, leaving the majority of Indians to fend for themselves. If governments wish to decrease unemployment and poverty in our nation, they should support people in the informal sector to develop and thrive. They play an important part in the economic development and growth of local economy. Municipal authorities see street sellers as nuisances and the encroachers on sidewalks pavements and they are unappreciative of the important services that the street vendors offer to the world's common public. Vendors on the street offer essential services to urban people while surviving on their own business, limited resources, and labour. The state government and municipal authorities have been asked to provide security for street sellers so that they may make a living without fear.

Dr. amarjeet singh

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It is one of the most widely used chemotherapeutic agents for various solid tumors in the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin is mainly due to its ability to cross-link with DNA, thus blocking transcription and replication, Subsequently inducing apoptosis in cancer cells. However, because of drug resistance and numerous undesirable side effects such as severe kidney problems, allergic reactions, decreased immunity to infections, gastrointestinal disorders, hemorrhage, and hearing loss especially in younger patients. Other common side effects include ototoxicity, neurotoxicity, gastrointestinal toxicity, hematological toxicity, cardiotoxicity, and hepatotoxicity. These side effects together reduce the life quality of patients and require lowering the dosage of the drug, even stopping administration, thus weakening the treatment effect Therefore, substantial effort has been made to explore the complicated biochemical processes involved in the toxicology of cisplatin, aiming to identify effective ways to reduce or eradicate its toxicity. This review summarizes and reviews the updated advances in the toxicological research of cisplatin.

Nehal

Objectives: Viral gastroenteritis is a major health problem that is common worldwide, especially in developing countries, and is responsible for the majority of childhood diarrhea disease. The aim of this study was to determine prevalence of rotavirus and enteric adenovirus frequency and the age and seasonal distribution of viral agents in children with acute gastroenteritis attending to our hospital. Materials and Methods: In this study, 6999 stool specimens were investigated for the presence of rotavirus and adenovirus. The samples were obtained between January 2013 and August 2019 from children age 0-17 suffering from acute gastroenteritis attending to our hospital. Frequency of rotavirus and adenovirus were retrospectively evaluated with regard to seasonal distribution, gender and age of patients. Results: Viral antigens were detected in 1341 (19.1 %) of the specimens examined in the study. Among the positive results, rotaviruses and adenoviruses frequency were detected in 14.7 %, 4.4 %respectively. Rota-adenovirus co-infection was 8.4 %(n=113). Whereas rotavirus antigen was determined in all age groups, the highest was found in children age 0-2 with a rate of 57.9 %. Moreover, considering the seasonal distribution of the cases, it can be said that rotavirus infections are mostly observed in winter and spring, while adenovirus infections are frequently detected in summer and autumn. Conclusion: Rotavirus and enteric adenovirus infections are important public health problems that caused hospitalization, morbidity and mortality among children <5 years children in our country. As well as an approach to prevention of acute gastroenteritis, it is very important to detect the agent correctly and quickly for the treatment approach.

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