A simple one pot synthesis has been developed for the synthesis 1,4-dihydropyridine using an efficient and reusable silica supported MgO solid catalyst by condensation of dimedone, ethyl acetoacetate, aldehyde and ammonium acetate in methanol as a solvent at room temperature. The reactions could be carried out under mild reaction conditions with very good yield of polyhydroquinoline, up to 92%. This catalyst could be recycled very easily, which makes this methodology environmentally benign.

Shilpa sangle

The present review shares updated data on the botany, distribution, medicinal uses, phytochemistry and pharmacology of Phaseolus vulgaris L. All provided information was obtained through Google scholar, Pubmed, SciFinder, Scirus, Web of Science and a library search.

Dr. salman ahmed

Justicia carnea, a plant rich in bioactive compounds, has traditionally been used as a haemoglobin booster by herbal practitioners in rural areas of Edo State of Nigeria. In this study, the methanol leaves extract of Justicia carnea was investigated for its antisickling potential in hemoglobin SS (HbSS) in-vitro by sodium metabisulphite assay and characterized by Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC). Terpenoids, saponins, glycosides, phenolics, flavonoids and alkaloids were present except tannins. Photomicrograph examinations revealed a reduction of sickle cells with a percentage decrease from 37.50%, and 22.22% down to 3.85% with 100 mg/mL crude extract of Justicia carnea at three durations, respectively. Detected compounds from Gas Chromatography-Mass Spectrometry included hexadecanoic acid methyl ester (Retention time (Rt): 21.46, 05.99%) and 9,12-octadecadienoic acid, methyl ester (Rt: 23.567, 02.59%) while the major constituent was phytol (Rt: 23.741, 67.28%). While kaempferol (Rt: 17.23, 16.72%) was the major component from High-Performance Liquid Chromatography quantification among resveratrol (Rt: 3.7, 13.85%), gallic acid (Rt: 5.88, 3.55%), Justicinol (Rt: 11.85, 01.34%) and phytic acid (Rt 5.06, 01.43 %). These compounds have been cited as physiological agents that reduce inflammation, and oxidative stress and potentially prolong the lifespan of cells across species. The antisickling results from this study corroborate and support the traditional use of the plant in treating patients with sickle cell anemia.

Mediterranean journal of pharmacy and pharmaceutical sciences

A state in southern India called Telangana has a rich and varied cultural history. There are numerous tribes in the area, and they have long coexisted peacefully with the environment. These tribes have distinctive traditions that have been handed down through the generations. The Gond, Koya, Lambada, and Banjara are notable tribes in Telangana. Over the years, these tribes have encountered several difficulties, such as land acquisition, displacement, and a loss of cultural identity. However, via several government initiatives and community-based programs, efforts are being undertaken to maintain their culture and give them more authority. Tribal Development has been in the agenda for discussion at several levels in different forums for quite some time and continues to be an important aspect for serious deliberation in Telangana, not only because of a significant portion of the tribal population but more importantly because of the inequality of their participation, both socially and economically. The conventional wisdom that the tribal population should not be integrated with the mainline population, does not cut ice any longer as tribals themselves are eager to participate in national development and construction. A major initiative to empower the tribals, in my view is through the provision of appropriate educational opportunities to the children of the tribal families, though the aspects like infrastructural and health are identified as critical inputs. The present book tries to disclose the situation of the Scheduled Tribes in Telangana State. Various eminent scholars and students, media friends delivered their observations through their research papers. As per the observations and findings, the book contains some valuable and instant suggestions for overall development of tribes that the Telangana State Government has to play a major role in this endeavour This article critically examines initiatives for greater participation in education by tribal communities in India, arguing that current policy does not effectively enough facilitate greater participation and may, in fact, go against the avowed principle of ensuring greater equity. The article relies on fieldwork-based study to support arguments for the need to be culturally sensitive in making appropriate provisions for the education of scheduled tribes in India. Reasons for high dropout rates and non-enrolment among tribal children are examined and some searching

Dr gedam kamalakar

Education in India is losing its relevance. This seems much more applicable to the situation in the present day of legal education. This essay aims to focus on two aspects of legal education. Whilst, on one hand, it aims to provide details of the existing legal education system on the other, it aims to drive more attention to the various improvements and developments that are needed. The essay firstly shall describe the existing legal education system. It shall analyze and assess the curricula that are available for the various undergraduate law degrees available in India. It aims to provide an understanding of the perceived distinctions between the three-year law degree and the five-year law degree. As a second aspect, the essay aims to explore options to further the quality of legal education in India by considering examples of various law schools or colleges of law across the world that have consistently proven themselves as a cut-above not legal education and research in their global scale. Also, from the learnings of the gaps in the curricula of the law degrees as discussed previously, the essay shall provide suggestions on the various plausible collaborations with foreign law schools and universities for the benefit of the Indian law schools and colleges of law. As a third and final aspect, as a measure to curb fake or bogus law schools or colleges of law within India and to enhance the employability of law graduates in India at par with those across the globe, the essay aims to provide suggestions applicable for the present-day legal education scenario.

Hari hara sudhan r

With the emergence of HR Analytics in organizations; gathering, interpreting, and measuring of HR data has become easy. HR Analytics act as a tool which is a combination of statistical techniques that enable collection, interpretation, measurement, and forecasting of data. HR analytics enlightens solution to the organizational problems and make accurate decisions. HR analytics hence aligns HR strategy with overall business strategy to obtain a competitive advantage. HR analytics has passed through phases of measuring the Sub HR functions. HR Analytics provides various opportunities to business as it forecasts workforce requirements, enables HR to achieve corporate goals, and improve organizational performance which helps businesses in finding success. Despite the success, the business faces some big challenges like data governance, skill gap among employees, top management support, and many other such challenges in implementing and using the HR Analytics tool in business. Various research scholars have discussed HR analytics from so many years. So many papers have come focusing on the conceptual part of HR analytics, past present and future scenario of HR analytics, acceptance of HR analytics in organizations, the extent of its utility, rise of HR analytics, and various other related studies. This paper aims to find out the challenges and opportunities faced by the business firm in implementing HR analytics as a tool in organizations. This study also gives the theoretical concept of HR analytics based on secondary data collected from previous research papers, journal of the year 2016- 2019 given by various research scholars, blogs, and websites that provide HR analytics recent data. The study will provide the pros and cons of implementing and using HR analytics.

Mamta gaur

This study presents a comprehensive bibliometric analysis of household consumption research in Maharashtra from 2017 to 2023, highlighting shifts in academic focus before and after the COVID-19 pandemic. The analysis explores key research trends, including foundational theories like the Keynesian consumption function and Engel’s law, while examining how themes such as income-consumption relationships, inequality, and economic resilience have evolved. Through citation network analysis, publication trends, and thematic evolution, we identify the most influential works, authors, and institutions that have shaped this field. Pre-pandemic research centered on established economic concepts, exploring factors like income distribution, economic growth, and household debt as predictors of consumption. However, post-2020, there is a marked shift towards understanding financial resilience, the impact of income shocks, and the role of government interventions in stabilizing consumption patterns during crises. This transition reflects an adaptation of traditional consumption models to account for pandemic-induced economic disruptions, emphasizing financial literacy and digital transformation as critical areas of study. Our findings contribute to a deeper understanding of the drivers of household consumption research in Maharashtra, providing insights into the socio-economic factors that influence spending behaviors in both stable and volatile conditions

Nandini jagannarayan

Vitamin C causes a significant change in pharmacological effects of some drugs which may lead to unpredictable responses. Vitamin C-haloperidol interaction has not been confirmed in vivo. This study was aimed to investigate the influence of vitamin C on some pharmacological effects of haloperidol (extrapyramidal side effects caused by the antipsychotic haloperidol). Albino male mice (n = 24, body weight of 20 - 40 gm) were divided into four groups and each of consists of six mice. Group I (control): given 1% Tween 80 solution, group II: given vitamin C in a dose of 100 mg/kg, group III: given haloperidol (2 mg/kg), while group IV: given a combination of vitamin C and haloperidol. All the treatments were given by intraperitoneal route of administration. Three sub-acute doses of different treatments were given at 24:0, 5:0, 1:0 hour before scoring. Parameters scored were catalepsy, ptosis, rigidity and akinesia. The experiment was repeated using vitamin C in a dose of 500 mg/kg. Both doses of 100 and 500 mg/kg of vitamin C significantly antagonized the effect of haloperidol by decreasing all the tested parameters. The results indicate that vitamin C decreases extrapyramidal side effects caused by the antipsychotic haloperidol and show that it successfully decreases catalepsy, ptosis, rigidity and akinesia in mice.

Mediterranean journal of pharmacy and pharmaceutical sciences

Abstract- The injection of the PV Grid power into an electric grid affects the power quality. The influence of the PV Grid in the grid system concerning the power quality measurements and the norms followed according to the guidelines specified in the International Electro technical Commission standard, are the active and reactive power variations, variation of voltages, flicker, harmonics and electrical behavior of switching operations. The work study demonstrates has overall good functional characteristics, better performance and faster response than existing systems. The proposed system of having STATCOM is smaller in size and less costly when compared to the existing system. In this proposed system static compensator (STATCOM) is connected at a point with a battery energy storage system to reduce the power quality issues. The effectiveness of the proposed scheme gives the reactive power demand of load and the induction generator. Simulation is done by using MATLAB / SIMULINK-Sim power system software.

Deepak patel

When we tested various industrial wastewater samples collected from different industries they shown high amount of toxic chemical components, and the samples are unfit for irrigation or for any kind of activity. Irrigation of untreated wastewater for long time leads to soil pollution by accumulating toxic salts in the soil. The regular growth of plant get effected by this water like improper growth, low chlorophyll content, low carotenoids content, low yield, etc. Three different types of oil yielding plants (Mustard, Ground nut and Sunflower) and three different types of vegetable crops (Tomato, Chilly and Brinjal) has grown by using different industrial wastewater samples. The primitive parameters of vegetative growth (imbibition, seed germination and vigour index) and nutritional components (chlorophyll a, b and carotenoids) have been observed in all the samples after growing for a particular time period. The imbibition test of seed samples in industrial wastewater samples have not shown significant variation compared to imbibition in distilled water sample. All the seeds in all wastewater samples absorbed almost negligible difference but in the percentage of germination there is significant difference. The tests for nutritional compositions have also shown significant decrease in chlorophyll a, b and carotenoids in all varieties.

Veerabhadraswamy al

Despite the evolution of modern technology, the users of hearing aids do not realize the persistence of feedback, while wearing the device until the condition becomes worse. The feedback cancellation algorithms, instead of cancelling the acoustic feedback, limits speech intelligibility. The paper presents a novel method for estimation of SNR based adaptive-feedback equalizers (SBAFE) algorithm to develop an optimized hearing aid for the feedback less sound transmission and achieving better speech discrimination. The data gathered for the optimization is visualized and compared with the traditional technology, which provides the subjective and objective quality of the hearing aids.

Jayanthi g

The wind tunnel experimental study has been carried out on a double delta wing of different geometrical configurations such as 80°/45°, 75°/45° and 70°/45° sweep angles given as Model I, Model II and Model III with various freestream velocities from 10 to 40 m/s with a step of 10 m/s in Hindustan Institute of Technology and Science, Chennai, Low Speed Wind tunnel (HITSLSWT). The experiment is conducted for the measurement of lift and drag forces using single component force balance. The investigation was done to look into the effects of changing the double delta wing's leading edge sweep angles. Three differentmodels have been tested at various angles of attack ranging from0° to +16° and 0° to −16° with 4° and four different freestream velocities based on the delta wing’s chord. It is observed that the influence of variation of leading edge sweep angles affects the performance of aerodynamic characteristics of themodel. The increase in angle in attack with increased velocity gives better aerodynamic performance. This paper provides good insight into the aerodynamic force measurement of double delta wing and the low-speed performance of the models.

Boopathy govindarajan

The advent of the World Wide Web and the rapid adoption of social media platforms (such as Facebook and Twitter) paved the way for information dissemination that has never been witnessed in the human history before. With the current usage of social media platforms, consumers are creating and sharing more information than ever before, some of which are misleading with no relevance to reality. Automated classification of a text article as misinformation or disinformation is a challenging task. Even an expert in a particular domain has to explore multiple aspects before giving a verdict on the truthfulness of an article. In this work, we propose to use a machine learning ensemble approach for the automated classification of news articles. Our study explores different textual properties that can be used to distinguish fake contents from real. By using those properties, we train a combination of different machine learning algorithms using various ensemble methods and evaluate their performance on 4 real world datasets. Experimental evaluation confirms the superior performance of our proposed ensemble learner approach in comparison to individual learners. The advent of the World Wide Web and the rapid adoption of social media platforms (such as Facebook and Twitter) paved the way for information dissemination that has never been witnessed in human history before. Besides other use cases, news outlets benefitted from the widespread use of social media platforms by providing updated news in near real-time to its subscribers. The news media evolved from newspapers, tabloids, and magazines to a digital form such as online news platforms, blogs, social media feeds, and other digital media formats. It became easier for consumers to acquire the latest news at their fingertips. Facebook referrals account for 70% of traffic to news websites. These social media platforms in their current state are extremely powerful and useful for their ability to allow users to discuss and share ideas and debate over issues such as democracy, education, and health. However, such platforms are also used with a negative perspective by certain entities commonly for monetary gain and in other cases for creating biased opinions, manipulating mindsets, and spreading satire or absurdity. The phenomenon is commonly known as fake news.

Kamal singh

Radio resource allocation in VCN is a challenging role in an intelligent transportation system due to traffic congestion. Lot of time is wasted because of traffic congestion. Due to traffic congestion, user has to miss their important work. In this paper, we propose radio resource allocation scheme so that user can utilize their time by taking the advantage of subscription plan. In this scenario, multitype vehicle identification scheme from real time traffic database is proposed, its history will match in transport database and vehicle travelling history database. Proposed method indicates 95% accuracy for multitype vehicle detection. Subscription plans are allocated to the user on the basis of resource allocation, scheduling, levelling and forecasting. This scheme is better for traffic management, vehicle tracking as well as time management.

Vartika agarwal

India is undergoing rapid urbanization, leading to significant transformations in land use, infrastructure, and population densities. Concurrently, climate change is intensifying heat waves across the country, exacerbating the vulnerabilities of urban populations. This study explores the intersection of urban growth and climate change, analysing how expanding cities, with their heat-absorbing materials and altered landscapes, contribute to the urban heat island effect. The research highlights how extreme heat waves, fuelled by global warming, are becoming more frequent and severe in Indian cities, affecting public health, energy consumption, and economic productivity. Furthermore, this study reviews adaptive strategies being implemented, such as green infrastructure, sustainable urban planning, and climate resilient policies, and assesses their effectiveness in mitigating the impacts of heat waves. Through an integrated approach combining climate science and urban studies, the paper emphasizes the urgency of rethinking urbanization to build heat-resilient cities in India. underline the importance of immediate policy interventions, public awareness campaigns, and investments in climate adaptation to safeguard the health and livelihoods of urban dwellers in the face of escalating heat risks.

Dr gedam kamalakar

This paper examines the influence of empowerment on job satisfaction in five-star hotels in Jordan. The influence of empowerment on job satisfaction remains a relatively unexplored area. A 52-item questionnaire, measuring empowerment and job satisfaction, was distributed to 332 employees in 12 five-star hotels in Jordan with a 56% response rate. Principal components analysis determined the factor structure and regression analysis determined the influence of empowerment on job satisfaction. The results revealed both structural and psychological empowerment have significant individual influences on job satisfaction, but more significant when structural and psychological empowerment are combined. Most of previous studies were conducted in western economies and little in the Middle East generally and Jordan in particular. This research contributes to the literature by including both dimensions of empowerment where previous scholars used only one.

Mukhles m. al-ababneh

Improper use of medicines may carry possible health dangers and more evidence continues to stand that adverse drug reactions to medicines are common but often preventable. Self-medication phenomena with over the counter medicines is common among people. It is regarded as essential issue of self-care. Over the counter medicines use such as analgesics among children and adolescents is continuously increasing in Libya. This constitutes an important public health concern. The aim of this study is to focus on adolescent's self-medication phenomena about the over the counter medicines that teens frequently used to treat minor and serious diseases. This work collected information throughout survey-comprised number of questions for the teenagers bought medicines from private pharmacies at two different secondary schools in Benghazi city, Libya, without prescription. The sample size was 120 students, 58 males and 62 females in age range of 15-18 years. Data collected from questionnaire were analyzed for pattern of medicine use. Male adolescents bought toothache and muscle-spasm medicines more frequently than female adolescents. On the other hand, female adolescents administered more over the counter medications monthly than males. The use of over the counter medicines has been found highly rated and exaggerated among secondary school teenagers. In conclusion, adolescents have to be educated regarding over the counter medicine use in Libya. The need for promoting the appropriate use of medicines healthcare system is an important issue. This can be achieved through an educational strategy involved different public sectors such as health and education authorities.

Mediterranean journal of pharmacy and pharmaceutical sciences

Presurgical Nasoalveolar molding have become an important procedure before proceeding with the surgical procedures for cleft lip and palate patient. PNAM reduces the size of the cleft which helps in better approximation and minimal scar formation.. To achieve this all proper tray selection is necessary and is a basic step in taking the impression of an infant. This article attempts to describe the various impression trays that can be used for the cleft patients routinely.

Apurva

This paper aims to study the restructuring and change management of SARHS, which in turn will be accompanied by some complex, difficulties and discussions that may include personnel emotion, which must be taken into account. We will guide SARHS managers by conducting a comprehensive study of majority factors that will affect the success of the process, considering and covering all views. Which will result in the dismissal of some employees and the closure of their jobs permanently in the new job structure. The study will include many theories, models and justified recommendations to be followed to ensure a successful and safe restructuring and management change free from unresolved impediments and difficulties that could lead to a setback. Finally, restructuring is not a result but the beginning of a new process

Mohamed sorogy

Currently, the use of internet-connected applications for storage by different organizations have rapidly increased with the vast need to store data, cybercrimes are also increasing and have affected large organizations and countries as a whole with highly sensitive information, countries like the United States of America, United Kingdom and Nigeria. Organizations generate a lot of information with the help of digitalization, these highly classified information are now stored in databases via the use of computer networks. Thus, allowing for attacks by cybercriminals and state-sponsored agents. Therefore, these organizations and countries spend more resources analyzing cybercrimes instead of preventing and detecting cybercrimes. The use of network forensics plays an important role in investigating cybercrimes; this is because most cybercrimes are committed via computer networks. This paper proposes a new approach to analyzing digital evidence in Nigeria using a proactive method of forensics with the help of deep learning algorithms - Convolutional Neural Networks (CNN) to proactively classify malicious packets from genuine packets and log them as they occur.

Dr. chandrashekhar uppin