We designed a mobile application to deal with Ischemic Heart Disease (IHD) (Heart Attack) An Android based mobile application has been used for coordinating clinical information taken from patients suffering from Ischemic Heart Disease (IHD). The clinical information from 787 patients has been investigated and associated with the hazard factors like Hypertension, Diabetes, Dyslipidemia (Abnormal cholesterol), Smoking, Family History, Obesity, Stress and existing clinical side effect which may propose basic non-identified IHD. The information was mined with information mining innovation and a score is produced. Effects are characterized into low, medium and high for IHD. On looking at and ordering the patients whose information is acquired for producing the score; we found there is a noteworthy relationship of having a heart occasion when low and high and medium and high class are analyzed; p=0.0001 and 0.0001 individually. Our examination is to influence straightforward way to deal with recognize the IHD to risk and careful the population to get themselves assessed by a cardiologist to maintain a strategic distance from sudden passing. As of now accessible instruments has a few confinements which makes them underutilized by populace. Our exploration item may decrease this constraint and advance hazard assessment on time.

Dr. chandrashekhar uppin

The coexistence of Moyamoya syndrome (MMS) and Graves’ disease (GD) is uncommon. Here, we report a case of a 41-year-old Filipino female, who presented with thyrotoxicosis and acute ischemic stroke. Based on her clinical presentation, cerebral computed tomography angiography, and thyroid function tests, she was diagnosed with MMS and GD. Her Burch-Wartofsky point scale score was 30, suggesting an impending thyroid storm. Antithyroid therapy was started with her neurological status deterioration initially, but after controlling the thyroid storm, the patient’s neurological status stabilized. She remained stable till she travelled to her country. We hypothesized that MMS in a patient with GD is mediated through anti-dsDNA antibodies, by altering key biological mechanisms, that is, inflammation, neutrophil extracellular traps, and apoptosis that drive a distinctive and coordinated immune and vascular activation. To the best of our knowledge, this is the first case of MMS associated with GD reported in Qatar.

Karishma

Along with computer technology, the demand of digital image processing is too high and it is used massively in every sector like organization, business, medical etc. Image segmentation enables us to analyze any given image in order to extract information from the image. There are numerous algorithm and techniques have been industrialized in the field of image segmentation. Segmentation has become one of the prominent tasks in machine vision. Machine vision enables the machine to vision the real world problems like human does and also act accordingly to solve the problem so it is utmost important to come up with the techniques that can be applied for the image segmentations. Invention of modern segmentation methods like instance, semantic and panoptic segmentation have advances the concept of machine vision. This paper focuses on the various methods of image segmentation along with its advantages and disadvantages.

Manoj kumar pandey

Breast cancer is the most prevalent invasive form of cancer in females and poses a significant challenge to overcoming the disease burden. The growth in global cancer deaths mandates the discovery of new efficacious natural anti-tumor treatments. In this regard, aquatic species offer a rich supply of possible drugs. Studies have shown that several marine peptides damage cancer cells by a broad range of pathways, including apoptosis, microtubule balance disturbances, and suppression of angiogenesis. Many side effects, including immune response suppression, characterise traditional chemotherapeutic agents. The discovery of novel putative anti-cancer peptides with lesser toxicity is therefore necessary and timely, especially those able to thwart multi-drug resistance (MDR). This review addresses marine anti-cancer peptides for the treatment of breast cancer.

Dr. salman ahmed

This study aims to determine the process of implementing PJOK learning in limited face-to-face learning during the Covid-19 pandemic in class V MIN 2 Palangka Raya City. This type of research is qualitative with case studies. Data collection techniques by observation and interviews. Meanwhile, data analysis uses descriptive data analysis. The results of this study show that:1) planning for sports and health physical education learning during the Covid-19 pandemic in MIN 2 Palangka Raya City: Teachers plan the PJOK class V learning program, develop the Annual Program, carry out Semester Program activities, carry out learning plans in the learning syllabus, distribute effective weeks.2) Implementation of Sports and Health Physical Education learning in MIN 2 Palangka Raya City, namely: development of the Annual Program into the Learning Implementation Plan, carrying out Semester Program activities, implementation of learning plans in the learning syllabus, online teaching, and learning process activities teachers explain teaching materials, apply learning methods.

Educare: journal of primary education

Patients who are on regular hemodialysis and who have advanced renal failure but have not yet started on renal replacement therapy have a high risk of tendon rupture, although this is a rare situation. We reported a case of 55-year-old male patient who had been on regular hemodialysis for the past 10 years. He presented with a sudden onset of pain and swelling in the left posterior ankle while climbing stairs. Ultrasonography revealed a complete disruption of the Achilles tendon, which was surgically repaired. His medical history was remarkable for the right Achilles tendon rupture a year ago. Investigations revealed tertiary hyperparathyroidism with chronic metabolic acidosis and high β-2 macroglobulin. With surgical repair, physiotherapy, and parathyroidectomy, the patient regained full active mobility. This case emphasized the importance of high parathyroid hormone level, metabolic acidosis, and high β-2 macroglobulin in the pathogenesis of tendons ruptures.

Karishma

In the present study, the bacterium Achromobacter xylosoxidans was isolated from tannery effluent sludge sample in Dindugal, Tamil Nadu, India and screened for its bio-control efficacy against selected plant pathogens viz., Alternaria solani, Curvularia lunata and Fusarium oxysporum under in vitro. It was observed that maximum percent inhibition of mycelial growth of C. lunata (95%), followed by A. solani (85%) and F. oxysporum (80%). An attempt was also made for testing its plant growth promoting traits such as production of Indole acetic acid (IAA), phosphate solubilization efficacy, Hydrogen cyanide (HCN), ammonia and catalase production. Significant amount of plant growth promoting traits were noticed. Further studies on mechanism of bio-control against plant pathogens and plant growth promoting activities of Achromobacter xylosoxidans need to be conformed under in-vivo condition.

Dr. saranya devi k

Development of thematic teaching materials based on Islamic values, especially those related to the contents of the verses of the Alqur'an and / or hadith as the basis of all science. In the available books, there are no thematic teaching materials that are integrated with the Al-Quran and Hadith, as well as Islamic values ??that are able to implement the core competencies of the 2013 curriculum, namely the competence of spiritual attitudes in thematic learning. The formulation of this research is: (1) producing thematic teaching materials based on Islamic values ??theme 7 (Leadership) class 6 Madrasah Ibtidaiyah Negeri 2 Jember. (2) to determine the effectiveness of thematic teaching materials based on Islamic values ??in learning. This study uses a research and development research type, the Borg and Gall model which is divided into 10 steps, namely: (1) research and data collection (2) planning, (3) product draft development, (4) initial field trials, ( 5) revising the results of trials, (6) field trials, (7) improving products from field tests, (8) conducting field trials, (9) improving product results, and (10) disseminating and implementing. The testing technique was carried out by comparing the pre-test and post-test values. The data was calculated using the t-test and processed using the SPSS application to determine the effectiveness of teaching materials. The results of this study indicate: the validation test produces an average of 88.79% with the criteria that the book is very suitable for use in learning. In terms of attractiveness, this book is very interesting to use for students, this is based on the results of the questionnaire data given to students with an average of 88.24% with very attractive qualifications. Meanwhile, from the results of the pre-test and post-test based on the t count which shows that it is greater than the t table, it means that the book is effective for use in learning. Pengembangan bahan ajar tematik berbasis nilai keislaman, terutama yang terkait dengan isi ayat Alqur'an dan/atau hadits sebagai dasar dari semua sains. Dalam buku yang telah tersedia tidak ada bahan ajar tematik yang terintegrasi dengan Al-Quran, dan Hadits, serta nilai-nilai Islam yang mampu mengimplementasikan kompetensi inti dari kurikulum 2013 yaitu kompetensi sikap spiritual dalam pembelajaran tematik. Perumusan penelitian ini yaitu: (1) menghasilkan bahan ajar tematik berbasis nilai keislaman tema 7 (Kepemimpinan) kelas 6 Madrasah Ibtidaiyah Negeri 2 Jember. (2) mengetahui efektifitas bahan ajar tematik berbasis nilai-nilai keislaman dalam pembelajaran. Penelitian ini menggunakan jenis penelitian pengembangan Research and Development, model Borg and Gall yang terbagi menjadi 10 langkah, yaitu: (1) penelitian dan pengumpulan data (2) perencanaan, (3) pengembangan draf produk, (4) uji coba lapangan awal, (5) merevisi hasil uji coba, (6) uji coba lapangan, (7) penyempurnaan produk hasil uji lapangan, (8) uji pelaksanaan lapangan, (9) penyempurnaan produk hasil, dan (10) diseminasi dan implementasi. Teknik uji coba dilakukan dengan membandingkan nilai pre-test dan post-test. Data dihitung dengan uji-t dan diolah menggunakan aplikasi SPSS untuk mengetahui efektifitas bahan ajar. Hasil penelitian ini menunjukkan: uji validasi tersebut rata-rata menghasilkan 88,79 % dengan kriteria bahwa buku tersebut sangat layak untuk digunakan dalam pembelajaran. Dari segi kemenarikan, buku ini sangat menarik untuk digunakan pada siswa, hal ini berdasarkan dari hasil data angket yang diberikan kepada siswa dengan rata-rata 88,24% dengan kualifikasi sangat menarik. Sedangkan dari hasil pre-test dan pos-test berdasarkan uji t hitung yang menunjukan lebih besar dari t tabel, berarti buku tersebut efektif untuk digunakan dalam pembelajaran.

Educare: journal of primary education

In the present study the effect of the ethanol extract of Culcasia falcifolia on the neurotransmitter levels were evaluated. Pentylenetetrazole (PTZ) (60 mg/kg body weight, i. p) was administered to all the groups of mice to induce convulsions. After observing the convulsion, all groups rats were sacrificed, whole brain was dissected out and separated the forebrain. The brain tissue was homogenized and then centrifuged. The aqueous phase was taken for the assay. The reading was obtained using spectroflurimeter. The result of the present study shows that the ethanol extract of Culcasia falcifolia at the dose of 200 and 400 mg/kg body weight significantly increased the level of inhibitory neurotransmitter GABA and also showed significant increase in the levels of dopamine, noradrenalin and serotonin when compared to seizure control group (PTZ treated group) and was almost equivalent to control group. The findings of the study showed that the extract at 200 and 400 mg/kg body weight significantly (p<0.001) increased the levels of GABA, dopamine, serotonin and noradrenaline. The ethanol extract of Culcasia falcifolia exerted antiepileptic activity by decreasing seizure susceptibility to pentylenetetrazole-induced seizure in mice due to restoration of GABA, serotonin, dopamine and noradrenaline concentration levels in mice brain.

Gracelyn portia

Urolithiasis is a common worldwide problem with high recurrence. This review covers Convolvulaceae seven (07), Costaceae four (04), Ebenaceae four (04), Fagaceae six (06), Hypericaceae eight (08), Lauraceae nine (09), Liliaceae twelve (12) and Lythraceae three (03) plants used globally in different countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Urolithiasis is a common worldwide problem with high recurrence. This review covers forty four (44) families starting from alphabet A to L and includes Bignoniaceae (05); Araceae, Burseraceae, Combretaceae (04); Annonaceae, Berberidaceae, Betulaceae, Gentianaceae, Gesneriaceae (03); Aizoaceae, Adiantaceae, Alismataceae, Aristolochiaceae, Asclepiadaceae, Bombacaceae, Cannabaceae, Cyperaceae, Geraniaceae and Iridaceae (02); Acoraceae, Adoxaceae, Armatellaceae, Aquifoliaceae, Araliaceae, Averrhoeaceae, Basellaceae, Begoniaceae, Bromeliaceae, Cactaceae, Calophyllaceae, Campanulaceae, Caprifoliaceae, Caricaceae, Celastraceae, Clusiaceae, Dracaenaceae, Dryopteridaceae, Elaeagnaceae, Grossulariaceae, Hyacinthaceae, Hydrangeaceae, Hypoxidaceae, llecebraceae and Juglandaceae (01) plant used globally in different countries. The plants of three families Asteraceae, Fabaceae and Lamiaceae are revisited to provide updated information. This review will not only be useful for the general public but also attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Objectives: Improper and inappropriate use of antibiotics is one of the possible factors affecting the transmission of antibiotic resistance is Because Pseudomonas aeruginosa is one of the most serious pathogenic bacteria in hospital environments and resistant It is an antibiotic that causes problems in treatment. This study aims to determine multiple resistances Pseudomonas has been treated with antibiotics, arsenic and metals. Materials and Methods: In this study, 23 strains of Pseudomonas aeruginosa were isolated from clinical specimens. for review Resistance of these bacteria to penicillin antibiotics was used by Kirby-Bauer method. The minimum concentration C.I.M. (and minimum lethal concentrations (C.B.M.) of antibiotics and heavy metals (cadmium, mercury) and arsenate Tubal dilution, agar and growth were performed in agar plate, respectively. Results: In this study, the highest and lowest MIC values obtained in Pseudomonas aeruginosa for metals, respectively. * 8 and 3 cadmiums (0.6 and 4.9 μg / ml), mercury (<0.12 and 4 μg / ml) and arsenate (10 × were 256 μg / ml). Of 23 strains, 84% to the antibiotic carbonicillin, 63% to piperacillin and 100% to 103 Arsenic and cadmium were resistant. Also, 82.6% of the strains were resistant to mercury. Conclusion: The results of this study showed that Pseudomonas aeruginosa strains have multiple resistance to arsenic, metals and the antibiotics are car penicillin and piperacillin.

Amirhossein jahromi

With a few years of teaching medical students and witnessing the status of medical education and health care delivery in Libya, for a decade or more, a reflection of what is happening in Libya, the country which has given respect and economic freedom to a teacher like me. The Republic of India, a South Asian country is the seventh largest nation by area, the second most populous country and the most populous democracy in the globe. One of the fundamental rights of the Indian constitution is the ‘Right to life’ which translates to “Right to Health”. India is a Federal country with 29 states and eight union territories [1]. Indian health care is taken care of by the States by organizing and delivering health care and the Central Government takes responsibility for international health treaties: medical education, prevention of food adulteration, quality control in drug manufacturing, national disease control and family planning. Indian health care under the public sector is provided free to people who are below the poverty line. Indian Public Health sector caters to 18.0% of total patient care and 44.0% of total in patient care. The total expenditure for health care is around 04.0% of the GDP and out-of-pocket expenses are around 69.0%. If it is calculated the cost of health care is around 1700 Indian rupees/capita/year [2]. It is true of Libya also. It has its national health a policy with free medical care and policy to cater to the needs of the Libyan people. With the civil unrest, and a transient locally elected government, Libya finds itself in very critical situation related to its economy and public services including public health. The hospitals built and their destruction because of the civil war lie in a very demanding conditions with poor supply chains and logistics to maintain the necessary demand and supply situation. The health care personnel physicians, nurses and public health workers are competent. They have to operate in a trying condition to save lives with limited healthcare facilities in the form of drug, medicine and medical equipment.

Mediterranean journal of pharmacy and pharmaceutical sciences

Abstract Background: Hansen’s disease is a chronic infectious disease with a wide range of clinical manifestations. The clinical diagnosis must be confirmed by histopathological and bacteriological studies in order to adequately manage the condition and prevent drug resistance. Aim: To perform a clinico-histopathological correlation of skin lesions in all patients with a clinical suspicion of Hansen’s disease. Materials and methods: A retrospective, hospital based, cross-sectional study was conducted in the Department of Pathology, Father Muller Medical College, Mangalore. Skin biopsies of all suspected cases of Hansen’s disease received over a period of three and a half years were included in the study. Haematoxylin and eosin, Fite-Faraco stained sections of all cases were reviewed. The cases were classified according to Ridley–Jopling classification into TT, BT, BB, I, BL, and LL. Clinical details of the patient, including type and site of lesion were obtained from the patient’s medical records. Clinico-histopathological correlation was done for all the cases. In addition, wherever available, the corresponding slit-skin smears were also included. Results: A total of 76 cases were clinically diagnosed as Hansen’s disease. Clinico- histopathological correlation was seen in 33/76 cases (43.42%). The most common histological subtype of Hansen’s was Borderline Tuberculoid (BT) - 24/76 cases (31.58%). Maximum agreement was seen in Mid-borderline leprosy (92.11%). Fite Faraco stain was positive in 21 out of 76 cases. Slit skin smears were available for 55 cases and positive in 20 cases. Conclusion: Due to clinical and morphological overlap, it is imperative to correlate the clinical, histopathological and bacteriological index results in order to accurately subtype the categories in Hansen’s disease.

Archana

This paper attempts to review the status of law in the context of the UK. The critical areas reviewed in the study included the nature of the legal systems within the UK, focusing on the role played by law within the community and the sources of law. In the second task, the connection between law and the business world is established, trying to ascertain the role of company law, employment laws, the law of contract, and the intellectual property to the businesses. Task three assessed the existing laws regarding the different types of business organizations created in the country, concentrating on the legal requirements for establishing the same. The last task focused on the recommendation that the study makes in conclusion regarding the dispute resolution processes available in the current business world.

Zamzam abdelazim

Despite the evolution of modern technology, the users of hearing aids do not realize the persistence of feedback, while wearing the device until the condition becomes worse. The feedback cancellation algorithms, instead of cancelling the acoustic feedback, limits speech intelligibility. The paper presents a novel method for estimation of SNR based adaptive-feedback equalizers (SBAFE) algorithm to develop an optimized hearing aid for the feedback less sound transmission and achieving better speech discrimination. The data gathered for the optimization is visualized and compared with the traditional technology, which provides the subjective and objective quality of the hearing aids.

Jayanthi g

The present study describes the use of an aqueous solution containing a blend of hydrotropic solubilizing agents (mixed hydrotropic substance’s solution) as a successful solvent system utilizing the concept of mixed hydrotropy for spectrophotometric analytical estimation of various conventional formulations as well as novel drug delivery systems. Frusemide, a poorly water-soluble drug, was estimated by application of mixed hydrotropic solubilization method. There was more than 15-fold enhancement in aqueous solubility of frusemide in a solution of blend of hydrotropic agents which consisted of 30% urea, 13.6% sodium acetate and 11.8% sodium citrate. This solvent mixture was employed to solubilize the drug from the fine powder of tablet formulations as well as the niosomes of frusemide. The selected λmax for spectrophotometric estimation was 333 nm. The hydrotropic agents used in the analysis and additives used in the manufacture of tablets and preparation of niosomes did not interfere in the analysis. Statistical data proved the accuracy, reproducibility and precision of the proposed method. The results suggested that proposed method is new, rapid, simple, accurate, and reproducible as well as employed aqueous solvent instead of organic solvents in estimation of drug from the dosage forms.

Archana mehrotra

Trace elements are minerals present in living tissues in small amounts. Some of them are known to be nutritionally essential, others may be essential, and the remainder are considered to be nonessential. Trace elements such as zinc, copper, selenium, iron, chromium and, others are essential elements for growth and body health. They form an integral part of many enzymes and bioactive centers that are responsible for biochemical reactions such as metabolism, protein and, DNA synthesis. They are said to contribute to the development of cancer based on epidemiologic evidence. The blood level of trace elements in the human body is affected by cancer and drug treatment. The low trace elements level is a sign of leukemia patients, where cancer cells consume body nutrients and essential elements for growth. The Libyan patients were divided into four age groups and were either newly or old diagnosed with leukemia, including patients with acute leukocyte leukemia, acute myeloid leukemia, chronic myelogenous leukemia, and aplastic anemia. The samples were tested for direct aspiration onto inductively coupled plasma spectrometry at specific wave lengths. The findings showed the blood level of trace elements in leukemia patients is lower than in the healthy individuals. A negative correlation between copper and zinc levels in leukemia patients was found. The copper level increases in leukemia patients as they get older.

Mediterranean journal of pharmacy and pharmaceutical sciences

Anemia is a common health problem among Libyan women. Age, heavy menstruation, and pregnancy are vital risk factors for this problem. In this study, we prospectively examined 60 Libyan women all of which were diagnosed with iron deficiency anemia, their hemoglobin levels were less than 10.0 g/dl. The level of hemoglobin is also analyzed for vegetarian and charcoal-eating women. We found that during pregnancy charcoal-eating women exhibit lower hemoglobin levels than non-eating women. Pregnant young women in the age of 17-27 years have the lowest hemoglobin levels than the other age groups. In addition, vegetarians, heavy coffee and tea drinking, and heavy menstruation in non-pregnant women, as well as breastfeeding, strongly lower hemoglobin levels as measured by their complete blood count.

Mediterranean journal of pharmacy and pharmaceutical sciences

Compliance with pharmacological therapy is the primary key to treating diabetes, but it has not received full attention from clinicians. Several systematic reviews of compliance factors have been conducted in several regions of the country. However, it does not feature studies from Indonesia. This study aims to systematically review the factors that can influence adherence to diabetes mellitus (DM) medication in Indonesia. A systematic literature review was conducted by searching the National (Garuda and Sinta) and International (PubMed and Science Direct) journal databases. Research that met the inclusion criteria was published from January 2011 to December 2020. The quality of the study was assessed using the SQAT guidelines. The research reporting method uses the PRISMA guidelines. Compliance factors are classified based on the domain of compliance factors, according to the World Health Organization (WHO). A total of 370 scientific research articles from the Garuda database (n=36); Science Direct (n = 108); PubMed (n = 18); Sinta (n= 208). Three hundred forty-one research articles were excluded, 29 full-text screening articles, and 16 research articles met the inclusion criteria for analysis. Factors that influence adherence to taking diabetes medication are social and economic (income, education level, and occupation), factors of personnel and health systems (health workers), factors of patient therapy (amount of diabetes medication, frequency of taking medication, and drug products), factors patient's disease (blood sugar levels, disease duration), patient factors (gender, emotional factors, social support, level of knowledge, and treatment satisfaction), and disease management factors (pharmacy counseling and education). Factors that influence adherence to taking DM medication in Indonesia are very diverse and are multi-factor. These factors can serve as relevant intervention targets. Clinicians must consider adjusting the frequency of taking medication and providing social support to DM patients.

Much ilham novalisa aji wibowo