Background:Calcium, the very important mineralhelps in growth and development ofinfants.Calcium helps in building strong bones, teeth,proper functioning of nerves and muscle, blood clot and in activating the enzymes that convert food into energy. Infants and Children are growing new bone all the time, they need continuous supply of calcium to support the healthy growth.Milk is the only food for infants which is richest source of calcium. Some infants are sensitive to lactose in milk because they have Lactose Intolerance. The present study aimsto develop an alternate milk forlactose intolerance infants with finger millet and pearl millet.Method:Traditional methods were used to process the milletswhich help in retaining and increasing the nutritional content in millets.The millet milk was analyzed for calcium content using the ICPMS.The millet milk was supplemented for 6 weeks to albino rats in comparison with cow milk. The tibia weight and length were measured and calcium content in tibia was analyzed. Result:The calcium content of the millet milk was 80mg/100mlwhere as in cow milk it was 120mg/100ml.The mean calcium content of the tibia inalbino rats was15.35±3.50mg/dl fed with millet milkand20.40±3.74mg/dl in rats fed with cow milk.Conclusion: The developed millet milk contain good amount of calcium on par with cow’s milk, it can be used as substitute milk for lactose intolerant infants.

Kimeera ambati

The pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs in the prevention and treatment process. At present, there is no proven therapy for this disease, although therapeutic approaches continue to be carried out using traditional medicines (herbal) and pharmacological therapy. Information about SARS-CoV-2 virology has rapidly developed and scientists try to provide a number of potential drugs. Remdesivir has strong in vitro activity against SARS-CoV-2. Several potential drugs are currently underway in a clinical trial. Chloroquine, hydroxychloroquine, and oseltamivir have not been proven to have efficacy, and the benefits of corticosteroids are still diverse. Current clinical evidence does not support the termination of angiotensin-converting enzyme 2 (ACE2) inhibitors or angiotensin receptor blockers, coagulation therapy in patients with COVID-19 concomitant with comorbidities.

Syahrul tuba

A new feature generates customer delight by using modern computer vision techniques to drive new search paradigms through visual discovery.

Senthilkumar gopal

A simple, precise, accurate, sensitive, specific and reliable stability indicating RP-HPLC method was developed for the simultaneous estimation of Miconazole (MIC) and Ornidazole (ORN) in pharmaceutical dosage form. The method was developed with mobile phase containing buffer (0.05M potassium dihydrogen ortho phosphate, ph3.5): Methanol in the ratio of 25:75, C18 (250 x 4.6mm, 5µm) as a stationary phase and flow rate was 1 ml/min. Detection was carried out at 236nm in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Miconazole and Ornidazole at 6.58 and 3.26 min respectively. The proposed method has been validated for precision, accuracy, robustness. Thus, the statistical analysis confirms that developed methods were successfully used for analysis of formulation and thereby can be used for routine analysis of drugs in Quality Control laboratories.

Prachi barbhaiya

Urolithiasis is a global health problem with a high recurrence rate. Different in vivo and in vitro models have been successfully used to evaluate the antiurolithiatic potential of medicinal plants. In vitro models study renal stone formation, and in vivo models reveal the pathological effects of urolithiasis. Thus, in vitro models are significantly and effectively used to evaluate prophylactic management, and in vivo models direct urolithiasis treatment. This paper describes the advantages, limitations and applications of both models, especially the role of in vitro studies in the evaluation of prophylactic management.

Dr. salman ahmed

Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone or its effects on peripheral tissues. Previous hospital based study have revealed high prevalence of hypothyroidism in pregnant women. Also, studies with small sample size indicated a rising trend of prevalence of hypothyroidism during pregnancy. Moreover, pregnancy is seen as a risk factor in the occurrence of thyroid dysfunctions. Thus, the aim of was to assess and analyze prevalence of hypothyroidism among Libyan pregnant women in Benghazi city in to study its relation and risk in pregnancy. The study was conducted on a sample size of 177 Libyan pregnant women in Benghazi city in Libya during 2018. A cross-sectional observational study was conducted in clinics located in Benghazi city. Responses to the question was coded and analyzed. The prevalence of hypothyroidism among the pregnant women was found to be 10.2% (n = 18) and no significant relation between age and hypothyroidism among women. Only nine percent of the pregnant women had medical conditions (as diabetes mellitus and high blood pressure). 28% of the hypothyroidism pregnant women are of the first gestation and 72% are of the second or more. 83% of the hypothyroidism pregnant women had no thyroidectomy. Thus, this study concludes that there is a high prevalence of hypothyroidism during pregnancy period in Benghazi and a national screening is necessary for hypothyroidism in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

The Cellular Manufacturing is adopted in batch type manufacturing industries nowadays for their production with increased productivity, less cost and time with effective control. The proposed optimization model is used to determine the cost of machine cells, i.e., machine duplication, part subcontract, inter intra cellular movements cost and cost of production associated with machine cell, such as machine reconfiguration and part inventory considering machine flexibility for various time periods. Initially, mathematical model is proposed to calculate machine cell cost with and without considering machine flexibility and then another lpp integer model is proposed to calculate the machine cell production and associated cost for the changes in time period, part type and volume considering machine flexibility. The manufacturing data in the incidence matrix and machine cell, part family data in the block diagonal form are given as input to the optimization programming language Cplex and the output are given for the two mathematical models. The data related to machine duplication, part subcontract, inter intra cellular movement; machine reconfiguration and part inventory are given. Two dimensional shop floor layouts are presented in rectilinear coordinates for all the problems for easy analysis of material movement length and shop floor area

S ramesh

During COVID-19 pandemic health professional need to develop good communication skills. Good communication skills will lead to professionalism. The information that are given to patients, their families and the community has to be transparent, true and scientifically relevant. The awareness one creates about the pandemic includes mode of infection, transmission, symptoms, vaccines, vaccination, viral heterogeneity and mutations. Such transmission of true information requires proper training of health personnel including the social media in developing good communication skills

Mediterranean journal of pharmacy and pharmaceutical sciences

The 2019 coronavirus (COVID-19) pandemic is spreading worldwide, with a spectacular increase in death missing any effective therapeutic treatment up to now. Molecular docking is a recognized computational tool to assist in early drug discovery and development. Molecular docking analysis was carried out using 2-(4-(aminomethyl)phenyl)isoindoline-1,3-dione Schiff base conjugates with SARS-CoV-2 protease enzyme and COVID-19 main protease in apo form 6M03). The compounds with the best normalized docking scores to protease enzyme (6LU7) were ARG3 (-8.1 kcal/mole), ARG7 (-8.1 kcal/mole) and ARG6 (-8.0 kcal/mole). The best docking ligands for main protease in apo form (6M03) were ARG7 (-8.7 kcal/mole), ARG6 (-8.6 kcal/mole) and ARG3 (-8.4 kcal/mole). The structural similarity between these conjugates inspired us to perform in silico studies to check their possible binding interactions with essential SARS-CoV-2 proteins. These studies provide insight into the potential binding between Schiff base derivatives and SARS-CoV-2 proteins to provide an insight for finding an effective therapy. Finally, ADMET calculations were performed for the Schiff base compounds to predict their pharmacokinetic profiles.

Mediterranean journal of pharmacy and pharmaceutical sciences

Newborn or neonate denotes to an infant in the first few days after birth. They are not small children when it comes to medicinal use and formulation development. Neonates include term, post-term and preterm babies. The neonatal period for preterm newborn infants is defined as the day of birth through to the expected date of delivery plus 27 days. The majority of drugs used in sick newborns receiving intensive care are unlicensed and off-label, exposing infants to a greater risk of adverse drug reactions (ADRs). This study is extremely important due to the presence of a variety of drug information sources if used together lead to medication errors. From this point of view, this approach is suggested to eliminate or minimize these varieties. Where the most important challenges in neonatal intensive care unit (NICU) is proper and correct calculations and administration. Drug-related events in a hospital setting are the highest cause of recorded errors such as in the USA and UK

Mediterranean journal of pharmacy and pharmaceutical sciences

: About 12% of the world population is affected by different forms of urolithiasis, the recurrence rate of which is 47-60% in females and 70-80% in males. According to WHO, 75% of people rely on traditional medicines to prevent and cure different ailments. Similarly, the majority of the world population uses several plants to treat problems related to the urinary tract system, of which urolithiasis is the primary cause. The review aims to collect data on the plants used in different parts of the world and cultures against urolithiasis, including their parts, mode of preparation, dosage, and administration. A literature review was conducted for traditionally used antiurolithiatic plants. The articles mentioning plant, parts, mode of preparation, dose and route of administration were selected. This information was extracted to compose Mono and Polyherbal antiurolithiatic formulations used in Appalachia (a region in the Eastern United States), Canada, India, Iran, Israel, Italy, Jordan, Latin America, Pakistan, Turkey and Yemen. The review provides essential data about plants used as antiurolithiatic in different parts of the world. The information is not only useful for ordinary people but also for the scientific community to carry out further phytochemical, pharmacological and toxicological studies for discovering new, effective, safer molecules against urolithiasis.

Dr. salman ahmed

Eighteen chickpea (Cicer arietinum L.) genotypes were evaluated for yield and their susceptibility reaction against gram pod borer, Helicoverpa armigera Hub. for three consecutive years under natural field conditions during rabi 2010-11, 2011-12 and 2012-13 at Hisar. Among these, maximum grain yield was realized from the genotype H 04-28 (13.00 q/ha) during the season rabi 2010-11 and it was statistically at par with RSG 931 (12.45 q/ha), H 03-56 (11.73 q/ha) and RSG 963 (10.82 q/ha) during rabi 2011-12 and it was statistically at par with GNG 1488 (10.01 q/ha), CSJ 140 (9.07 q/ha) and H 03-56 (8.95 q/ha) during Rabi 2012-13 and it was statistically at par with RSG 888 (8.80 q/ha) and GNG 1591 (7.79 q/ha). However, on the basis of average of three years (2010-11 to 2012-13), the maximum yield was exhibited by the genotype GNG 1488 (9.36 q/ha) followed by RSG 931 (8.95 q/ha), H 04-28 (8.32 q/ha) and H 03-56 (8.20 q/ha). The genotype H 03-56 flowered earliest in 68-71 days and proved the best donor against gram pod borer with PSR 4.7. Minimum larval population was recorded in BG 256 (15.8 l/mrl) and it was followed by GL 25016 (17.5 l/mrl) and H 04-28 (18.5 l/mrl). Minimum per cent pod infestation by H. armigera was recorded in genotype H 01-27 (27.8%) and it was superior over all other genotypes. It was followed by H 03-56 (29.5%), CSJ 140 (30.9%) and GNG 1488 (31.3%). H 01-27 proved least susceptible genotype under natural field condition. The genotype H 03-56 flowered earliest and seemed to be the best as potential donor for pod borer’s tolerance under late sown condition. GNG 1488, RSG 931, H 04-28, H 03-56 and RSG 963 proved promising genotypes for yield and against H. armigera. These genotypes may further be utilized in breeding programmes to develop the high yielding and tolerant cultivars against gram pod borer.

Dr. babu lal jat

Industry 5.0 is still a developing concept, but it is expected to leverage a range of advanced technologies to facilitate human-machine collaboration and enable more customized and sustainable manufacturing.This research paper tried to discuss the opportunities and challenges in the implementation of Industry 5.0. It primarily explored the need to transform from Industry 4.0 to Industry 5.0. The research paper further studied the technologies needed for the implementation on Industry 5.0 and also the principles of Industry 5.0.

Dr. kishor bholane

In the research described in this paper, we used computer simulations to analyze and compare different types of game strategies in the popular board game Don't Get Angry. Following a brief introduction, we summarized a few previous research papers examining similar board games' game strategies. Next, after a review of the Don't Get Angry game's official rules, we outlined four strategies that can be applied to increase the likelihood of winning. We simulated 50,000 games in which all four players made their moves randomly and 50,000 games where each used a different strategy. We tracked how frequently each player finished first, second, third, or last during the simulations. Furthermore, we recorded how many rounds were needed to complete the game for each player, how many times the players’ pawns were kicked out and returned to their houses by other players, and the number of players’ remaining steps during every gameplay. From the analysis of the recorded data, we could conclude that significant differences exist in the chances of winning the game for the examined strategies when all players use different strategies. The results improve the specific domain knowledge for the Don't Get Angry board game. It may help create more vigorous computer opponents and encourage further study to create a tool for evaluating students' strategic thinking while playing.

Ladislav végh

Development of Human Resources is being given due importance by all the organizations as it aims at developing all the employees of an organization in a planned manner to acquire, sharpen and apply their existing capabilities as well as their inner potentials. HRD is a total system in which its various mechanisms are embedded together to act as an integrated unit. No sub-system can work in isolation. The researches show that the working of each sub-system has its impact on other subsystems e.g. Performance appraisal is basis for assessing training needs, career planning etc. Training is useful tool for increasing individual efciency. It is also a part of employee welfare and is used for promotions. Implementing these HRD sub-systems helps in developing a climate in the organization where the people collaborate with each other; respect and trust others and work as a team. This, in turn, develops a highly positive and motivated workforce which enables the organization to achieve its goals. Human being is a creature composed of heredity and environment and creates values for their own. In the context, during the interactions with others, the values manifest spontaneously. Human beings are tempted by all kinds of emotions, impulses, instincts, prejudices, wishful thinking, hopes, fears, desires, and almost everything.

Dr.kailaspathi vishwakarma

This article explores the increasing prevalence of mental health disorders and the pivotal role of Artificial Intelligence (AI) in diagnosis and treatment. It highlights how AI enhances diagnostic processes, continuous monitoring, and personalized mental health care experiences. The piece showcases examples of AI applications in detecting signs of mental illness through speech and video analysis, emphasizing improved accuracy for conditions like depression, Post-traumatic stress disorder PTSD, Attention deficit hyperactivity disorder ADHD, and Autism spectrum disorder ASD. Additionally, it discusses AI's role in continuous monitoring, prediction, and addressing the shortage of psychiatrists globally. The article concludes by introducing AI-based apps designed to assist individuals in managing depression, serving as complementary tools in collaboration with healthcare professionals. Overall, it underscores the transformative impact of AI on mental healthcare, offering innovative solutions for more effective, personalized, and accessible support.

Dhruvitkumar talati

Nine fruit morphological traits were studied in ten stands of Jatropha curcas spread in eight forest divisions of Uttarakhand. Variation was examined at stand level as well as at tree level. Significant differences were found among stands for fruit length, fruit diameter, pericarp weight per fruit, seed: fruit weight ratio, kernel: fruit weight ratio and pericarp: fruit weight ratio traits while all morphological traits showed significant differences among trees within stands. The estimation of the variance components, however, revealed that the fruit traits, especially weight traits viz. fruit weight, total seed weight per fruit and total kernel weight per fruit have negligible contribution from stands and small contribution from trees. Maximum variation was found among fruits within trees (i.e. at fruit level or error). Pericarp weight per fruit and fruit ratio traits (i.e. seed: fruit weight ratio, kernel: fruit weight ratio and pericarp: fruit weight ratio) were affected to small extent by stand per se. The repeatability of all fruit traits at tree level were also low to moderate (0.105 to 0.278)

Kshitij malhotra

Blind Taste Test of Soft-drinks – A Comparison Study on Coke and PBrand equity is “The differential effect that brand knowledge has on consumer response to the marketing of that brand” (Keller-1993).Brand equity is the added value a product acquires as a result of past investments in the marketing activity for the brand.This marketing activity resides in the mind of customers and as a result customer shapes a perception about the brand, biggest challenge here is creating positive perceptions by ensuring that customers have right type of experiences with product so that both functional experiences as well as emotional experiences become associated with the product.Thus Brand perception is the imagewhich a brand creates in the mind of the customers due to the various associations linked with the brand. The simplest way tounderstand what brand equity is to understand the typical results of product sampling and comparison tests. One such test is blind taste test in which consumers sample a product without knowing the brand what they consume and consuming the same product knowing brand i.e., open test. When consumers report different opinions about branded and unbranded versions of identical products, it must be the case that knowledge about the brand has changed their perceptions. Thus, consumers’ perceptions of product performance are highly dependent on their impressions of the brand that goes along with it Pepsi

N ramanjaneyalu

Experiment was carried out to standardize the artificial diet for mass rearing of Helicoverpa armigera (Hübner) under laboratory conditions. The average length and breadth of egg was 0.51±0.06 mm, 0.46±0.37 mm and 0.52±0.03 mm, 0.48±0.62 on artificial and natural diet. The average length and breadth of first, second, third, fourth and fifth instar larvae was 1.40±0.09 mm, 0.46±0.02 mm and 1.42±0.01 mm, 0.47±0.16 mm and 4.03±0.22 mm, 0.66±0.07 mm and 4.31±0.01 mm, 0.89±0.25 mm and 8.19±0.36 mm, 1.57±0.63 mm, and 10.29±0.72 mm, 1.87±0.91 mm and 18.70±0.44 mm, 2.78±0.040 mm and 20.15±0.03 mm, 3.17±0.55 mm and 26.01±0.19 mm, 4.09±0.39 mm and 27.32±0.027 mm, 5.88±0.69 mm, respectively with the average duration of 2.69±0.32 and 2.54±0.29, 3.77±0.65 and 3.79±0.11, 3.88±0.49 and 3.72±1.23, 5.35±0.55 and 5.72±0.91 and 6.61±0.008, 6.46±1.07 days, respectively on artificial as well as on natural diet. The average length and breadth of adult male and female was 18.01±0.48 mm and 35.09±1.25 mm, 18.51±1.04 mm and 38.11±1.37 mm, 19.00±0.18 mm and 19.10±0.49 mm, 37.75±1.27 mm and 41.23±1.69 mm, respectively. The average pre-oviposition, oviposition and post-oviposition period was 2.52±0.86 and 2.76±0.84 days, 4.93±0.78 and 5.08±0.90 days and 0.65±0.49 and 0.79±0.93 days, respectively. The total life cycle of male and female was 40.50±2.29 and 41.81±1.89 days and 42.59±1.77 and 43.80±1.93 days.

Dr. babu lal jat

Pharmacists are expected to play major roles as members of diverse perioperative care teams besides implementing medication safety standards, pharmacist’s roles include optimizing drug therapy and other clinical interventions. Yet, developing general perioperative management as another crucial role operation room, pharmacists play and incorporating it into pharmaceutical education would be important. Enriching perioperative care provided by pharmacists can contribute toward improving the clinical competence of these professionals. Presently, there are no pharmacists in Zawia who participate in perioperative care. The objective of this study was to assess the pharmacist's knowledge of general anesthesia and drugs used to anesthetize patients who suffer from hypertension. A cross-sectional study was conducted in Zawia City, Tripoli in 2023. A self-designed questionnaire was distributed to 100 pharmacists. The study found that more than half of the pharmacists have humble knowledge about the drugs used in anesthesia, the findings indicated weakness in their information about drugs used to manage hypertension in surgery, and 36.0% know that sodium nitroprusside is used to control blood pressure during the operation. In conclusion, this study reported that some of the study's pharmacist participants had weak points that contributed to a high percentage of incorrect knowledge. These weak points may be attributable to poor educational preparation or a lack of training before the pharmacists began working in hospitals.

Mediterranean journal of pharmacy and pharmaceutical sciences