Background: Acute and chronic heart or kidney failure affect each other in cardiorenal syndromes (CRS). In CRS, hemodynamic and non-hemodynamic changes occur, causing acute or progressive renal and cardiac failures. CRS is classified into five types based on the first organ failure and causes failure of the other organ. We believe that the current CRS classification is not the correct one that effectively describes the underlying cause of CRS. Hence, we consider it better to be classified into three categories (cardiorenal, renocardiac, and cardio-reno-cardiac syndrome) and then subdivided into acute and chronic types or types 1 and 2 (respectively, according to the onset of the underlying type of failure (i.e., acute or chronic). Other subtypes that occur inthe heart and dysfunction occur simultaneously are acute cardio-reno-cardiac syndrome (type 5) and Chronic cardio-reno-cardiac syndrome (type 6). Aim: In Part 1 of the review series, the pathophysiological mechanisms and clinical and therapeutic applications of all types of CRS will be narratively discussed and updated. Furthermore, we provide a comprehensive review of diagnostic biomarkers and their clinical significance in the identification, outcome prediction, and treatment of all CRS types. Method: An extensive search of PubMed, Google, EMBASE, Scopus, and Google Scholar was conducted for review articles, original articles, and commentaries published between Jan 2010 and Aug 2024 using different phrases, texts, and keywords, such as CRS, renocardiac syndrome, and CRS. The topics included secondary CRS, CRS pathogenesis, CRS therapy, SLGT inhibitor use in CRS, novel therapy in CRS types, and prevention of CRSs. Conclusion: Renal and cardiac failure in patients with CRS seem to have different pathophysiological mechanisms. Early detection and treatment can improve the outcomes of CRS. Clinical manifestations and therapy protocols vary according to pathophysiology. Hence, new guidelines and research on universal diagnostic and treatment techniques are urgently required. Moreover, the current nomenclature for CRS is confusing; therefore, we believe that a new nomenclature system should be introduced, reducing confusion and making differentiation between CRS types easier and less confusing.

Karishma

Background: Cancer is the word used for a tumor that spreads & destroys the host and is one of the leading causes of morbidity and mortality in developed and developing countries. Good nutrition is important for good health. Methods: Non-experimental descriptive research design was adopted for a study to assess knowledge on meeting nutritional needs among 100 oncology patients receiving chemotherapy at Bhagwan Mahaveer Cancer Hospital & Research Centre, Jaipur. Sample selection using a non-probability convenient sampling technique. Data were collected through a self-developed structured knowledge questionnaire. Results: Our results revealed that the majority of cancer patients, 43%, were in the age group of 31-40 years, 39% had no formal education, 32% had secondary education, and 17% had primary education. 76% were males, 24% were female, and 87% of participants did not have a family history of cancer. 55.23% of patients reported that nurses did counselling. The majority (67%) of respondents reported that they had previous information on meeting nutritional needs through diet counselling, and 33% reported they didn’t have any information about meeting nutritional needs. Most (45%) of cancer patients had poor knowledge, 26% had average knowledge, and 29% had good knowledge scoring. Conclusion:Conclusion:Conclusion:Conclusion:Conclusion:Conclusion:Conclusion:Conclusion:Conclusion:Conclusion:Conclusion: We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most (45%) of oncology patients receiving chemotherapy had poor knowledge We concluded that results show most 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However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. 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However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that al needs during chemotherapy. However, the researcher developed an information booklet, and he hopes that the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy the booklet will surely enhance oncology patient’s knowledge of meeting nutritional needs during chemotherapy .

Dr k c yadav

Because of globalisation's intense change and competition pressure, businesses are driving from the company's dimension of individual management to collaborative cooperation approaches aided by the anticipated business strategy. A business strategy is a decision or action of a business or organisation to attract customers and achieve the organisation's objective. These strategies are the master plan for securing a competitive position of the firm market area of the competitors. Through business strategies, organisations will carry their business operations and fulfill the customers' desires and demands. Multination organisations and firms establishing subsidiaries and business entities in international markets or foreign countries must adopt different strategies during the integration process. The macro-economic and intercultural factors are the epicenter for change and must be considered in complex ventures. In the modern competitive market, multinational firms must collaborate and communicate with the partners, suppliers and customers through a complicated and temporary product supply chain. Business strategies involve complex processes requiring information on the diverse sources that need simultaneous changes by the managers of entrepreneurs. I this report, I choose Tesla Inc or Tesla Motors to explore the key strategies they have anticipated to inherit the global motor vehicle sector within the past few decades. The organisation was founded in 2003 by a group of various engineers. Tesla Motors deal in the automotive industry and has transformed its services to the global society.

Zamzam abdelazim

In this paper, investigations are made to analyze the human body temperature during wound healing process due to surgery. Wound is considered after the skin graft. Skin graft is a technique used in plastic surgery. Skin is the first line of defense between the human and environment, it is very susceptible to damage. Internal body or core temperature (Tb) is one of the clinical vital signs along with pulse and respiratory rates. Any disturbance in body temperature will drive complexities in wound healing process. These studies are important in the mechanism of establishing the limits of thermal regulation of human body during the healing process in different situations and conditions. The Finite element method is used to analyze tissues temperature for normal tissues (donor site) and abnormal tissues (tissues after surgery). Appropriate boundary conditions have been framed. Numerical results are obtained using Crank Nicolson Method.

Manisha jain

The global endeavor to develop and deploy COVID-19 vaccines has underscored both significant scientific progress and enduring disparities in worldwide access. This analysis examines regional vaccine distribution patterns across World Health Organization (WHO) regions—Africa, the Americas, Eastern Mediterranean, Europe, and Western Pacific—revealing substantial variations in vaccine types and manufacturer contributions. Data indicate that the Americas and Europe demonstrate a broad vaccine portfolio, with prominent contributions from major international pharmaceutical companies alongside regionally developed vaccines. Conversely, African, Eastern Mediterranean, and Western Pacific regions show considerable reliance on vaccines from Asian (notably China and India) and Russian manufacturers, in addition to Western products. This distribution highlights the influence of geographical proximity to manufacturing centers, regional alliances, and local production capabilities (e.g., CIGB and Finlay in the Americas, COVIran Barakat in the Eastern Mediterranean, and various Chinese products in the Western Pacific) on vaccine availability. Predominant vaccines by country count include Pfizer-BioNTech's Comirnaty, AstraZeneca's Vaxzevria, Janssen's Ad26.COV2-S, Moderna's Spikevax, Beijing CNBG's BBIBP-CorV, and SII's Covishield. The observed regional variations in vaccine types and supply chains carry implications for comparative effectiveness research, the understanding of differential immune responses, and the evaluation of pandemic control strategies. Furthermore, inconsistencies in global data reporting and product nomenclature present challenges for comprehensive analysis. The findings emphasize the importance of diversified supply chains, the growing role of regional manufacturing in enhancing global health security, and the need for standardized global data for a more profound understanding of vaccine equity and efficacy to inform future pandemic responses.

Mostafa eissa

ROS (Reactive Oxygen Species) production via oxidative stress leads to selective neuronal degeneration and finally results in neurodegenerative diseases. PD (Parkinson’s disease) is one of the second most common neurodegenerative disease caused by overproduction of ROS due to the activity of xanthine oxidase. XO activity inhibitors may prove to be promising antiparkinson agents. Present investigation describes the synthesis and characterization of fluoro substituted pyrazolyl pyrazoline derivatives using spectrometer and 1HNMR spectra. Molecular docking studies of NAP1-NAP5 derivatives were performed in silico using molecular docking software. The resulting dock score in terms of D score has been compared with the standard XO inhibitor i.e. Allopurinol and Oxypurinol. The in silico approach used to study the Drug and Enzyme interaction using docking mechanism. Results indicated that the NAP derivatives accounted for better region specificity towards XO. It shows the strong binding interaction of ligand and receptor calculated on the basis of D score; hence the D score shows highest affinity. Overall score tabulation for D score as 2NAP1: -101.78; 2NAP2: -118.32; 2NAP3: -99.921; 2NAP4: -105.22; 2NAP5: -101.56; accordingly with the comparison of standard ligand molecule i.e. Allopurinol: -37.016 and Oxypurinol: -37.233.

Dr. wahul umesh b

Youth entrepreneurship contributes to the social, cultural, and economic development of society, especially in many developing countries. The idea of encouraging young people to start businesses for a variety of reasons is now widely encouraged. However, there are many challenges and doubts faced in starting a business particularly after the Covid-19 is over. Therefore, the community service was carried out by lecturers at Business School, Universitas Pelita Harapan Medan Campus, providing the onsite seminar and training to 70 high school students at Santo Nicholas School in February 2023. The purpose of the community service was to encourage the students to plan their business projects by presenting data and information on the latest trends and issues in entrepreneurship and finance, as well as conducting one-to-one sessions with the students. Most of the students were enthusiastic throughout the activities resulting in several business plans and proposals being created at the end of the community service. It is implied that young people are indeed motivated to begin their entrepreneurship journey and school is the right place for them to acquire the necessary knowledge and skills. Teachers and parents are suggested to continue to assist the students by providing the commitment and funding required to begin and sustain the business.

L

Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

The cross line movement according to the two labor and products is the thing to take care of in the present worldwide economy. Worldwide exchange labor and products has for some time been a standard, for different advantages that gather from it. There have been numerous respective and multilateral arrangements comparable to cross line exchange dealings. The development of administrations area that decidedly influences the everyday daily routine and guidelines of experiencing or personal satisfaction. The World Trade Organization (WTO), of which in excess of 156 nations are individuals, has an understanding according to global administrations exchange. The General Agreement on Trade in Services (GATS) is the WTO's arrangement that administers exchange 12 sorts of administrations, including 'instruction administrations'. One of the basic inquiries or issues in such manner would be corresponding to the sort of college to be permitted to set up its grounds or branch or in any case offer training administrations. This paper would endeavor to give some potential experiences into this issue. Internationalization and globalization are the two Global ideas terms conversely utilized as far as higher education. Most impressively, the test to set up colleges will come from the worldwide monsters of the interchanges, data innovation and mixed media ventures worldwide suppliers, packed with capital, ready to get to remarkable global researchers and educators, talented in giving in situ understudy support at the same time in numerous nations, and equipped for expediting proficient accreditation and acknowledgment all throughout the planet. Quality in the subsequent 'worldwide virtual colleges' will be high, normalization will make cost structures that are powerfully serious, brand acknowledgment will be acquired, maybe by accepting one of the incomparable Ivy League organizations as an accomplice, or on the other hand by moving into advanced education a prevailing brand from the correspondences or processing ventures.

Dr gedam kamalakar

This study examined work-life balance and teacher engagement in private secondary schools in Rivers State. Three research questions and three hypotheses guided the study. The study adopted a correlation research design with a population of 7,143 teachers (2,676 males and 4,467 females) in all the 275 private secondary schools in Rivers State. The sample size of 714 teachers was drawn through a proportionate stratified random sampling technique, which represents 10% of the population. Two self-designed instruments entitled: “Work-life Balance Questionnaire (WLBQ)” and “Teacher Engagement Questionnaire (TEQ)” were used for data collection. The instruments were in two sections –A and B. Section A consisted of the demographic factors while Section B contained the variables that were used to elicit information from the respondents. Section B contained 20 items on Work-life Balance and 15 items on Teacher Engagement respectively. Face and content validities were ensured by experts in the relevant areas. The Cronbach’s Alpha reliability method was used to establish the internal consistency, and indexes of .79 for WLBQ and .83 for TEQ were established respectively. Research questions 1 and 2 were answered using simple regression while research question 3 was answered using multiple regression. Hypotheses 1 and 2 were tested with a t-test associated with simple regression while hypothesis 3 was tested using ANOVA associated with multiple regression at 0.05 alpha level. The findings of the study revealed, among others, that work-life balance significantly and jointly predicted teacher engagement to a very low extent in secondary schools in Rivers State. Based on the findings, it was recommended, among others, that both employers and school managers should create flexible work environments that promote work-life balance for teachers so as to motivate them to perform optimally for the attainment of educational goals.

Fxintegrity publishing

Strain improvement studies were conducted for the production of L-asparaginase from a marine fungus Beauveriabassiana SS18/14 by employing physical and chemical mutagens, in a systemic manner to obtain mutants that have higher L-asparaginase production. The wild strain produced 6.32 IU/mL of L-asparaginase activity while the UV mutant UVF-4 yielded 8.34 IU/mL and nitrous acid mutant UVF4-N-2 exhibited 10.44 IU/mL enzyme activity. The overall strain improvement programme increased L-asparaginase activity 1.65 times with respect to the parent wild strain

Dr.p.v.kamala kumari

 ABSTRACT Macrotyloma uniflorum, commonly known as horse gram, is an underused pulse that holds great potential as a supply of nutrition and functional compounds. This review paper aims to provide a comprehensive overview of the nutritional composition, Pharmacological activities, health benefits, and potential applications of Macrotyloma uniflorum. Horsegram has a high amount of protein, dietary fibre, and a variety of vital minerals and vitamins that make up its nutritional profile. Horsegram also has a high content of antioxidants, flavonoids, and phenolic compounds, all of which contribute to its potential health advantages. Horsegram intake has the potential to help manage a number of chronic conditions, including diabetes, obesity, cardiovascular problems, and gastrointestinal disorders, according to many studies. The review investigates the possible health advantages of Macrotyloma uniflorum, emphasising its function in controlling blood sugar, managing weight, lowering cholesterol, and antioxidant activity. Horse gram's medicinal potential is further increased by the presence of bioactive substances that include anti-inflammatory, antibacterial, diuretic, antiobesity, analgesic, anaphylactic action, and anticancer activities. In conclusion, this review paper presents a comprehensive evaluation of Macrotyloma uniflorum, highlighting its nutritional composition, health benefits, and potential applications. The findings underscore the significance of horse gram as a valuable functional food ingredient and encourage further additional investigation of its therapeutic properties for human health and well-being.

Asawari mansabdar

Over the last few years, Libyan scientists and researchers have investigated most of the native wild plants from various regions of Libya. Since tens of years, research groups from Libyan universities, especially at Faculty of Pharmacy and Biotechnology Center, have assessed the native wild plants for their detailed biochemical and pharmacological active composition in order to identify their biologically active compounds with health and therapeutic benefits and economical values. Recent scientific reports stated that several wild Libyan plants carry various bioactive compounds which have a substantial role in treating certain human diseases such as diabetes mellitus, inflammations, microbial infections, cancer, etc

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: In addition to the recent civil war in Yemen, the COVID-19 pandemic resulted in a collapse of the health system, a decline in vaccination coverage, and the spread of numerous outbreaks. In 2022, a measles outbreak impacted Al Dali governorate. This study aimed to describe the demographics of measles patients, measles risk factors, and disease outcomes in Al Dali Governorate, Yemen. Methods: All measles-infected children who sought medical attention at Al Tadhamon Hospital in Al Dali, Yemen, between February and December 2022 were included in this prospective and observational study. Results: During the study period, 154 parents gave their consent to enroll their children in this study; 88 (57.1%) were males, and 66 (42.9%) were females. The mean age of the children was 3.56±2.90 (0.3–12 years). More than half of the mothers (n=88, [57.1%]) were illiterate or had a basic educational level, while most of the fathers (n=126, [81.8%]) were well-educated. Nutritional status was normal in most children (n=146, [94.8%]), and all children were unvaccinated. Most children (n=152, [98.7]) came from areas having measles and most of them (n=130, [84.4]) were in contact with measles cases. Health facilities were close (<3 km) to many children (n=151 [98.1]), and house ventilation was good in 66.2% (n=102) of cases while crowdedness was found in 135 (87.7) cases. Family members were 7 or more in 90 (58.4) cases. Two children under the age of 5 years died because of the disease. Conclusion: Our study showed that the main risk factor for the recent measles outbreak in Al Dali governorate was lack of vaccination, as all involved children were unvaccinated. Routine immunization needs to be reinforced through health centers in different districts and community education about the dangers of the disease and the benefits of the vaccines should be enhanced to prevent outbreaks from recurring.

Karishma

This paper attempts to review the status of law in the context of the UK. The critical areas reviewed in the study included the nature of the legal systems within the UK, focusing on the role played by law within the community and the sources of law. In the second task, the connection between law and the business world is established, trying to ascertain the role of company law, employment laws, the law of contract, and the intellectual property to the businesses. Task three assessed the existing laws regarding the different types of business organizations created in the country, concentrating on the legal requirements for establishing the same. The last task focused on the recommendation that the study makes in conclusion regarding the dispute resolution processes available in the current business world.

Zamzam abdelazim

Several studies demonstrate a strong correlation between talent and organizational performance. This view has led to continued improvement of methodologies, human resource scorecards, benchmarking, and engaging in best practices aimed at attracting both talent and better business management. As all these underline advancements of organizational strategic goals, it also determines the development and alignment of individual performance (Savanevičienė and Vilčiauskaitė, 2017, pg. 247). Although most of the studies involve for-profit corporations incorporating them in various industries proves to be both logical and psychologically sound. Regarding this project, the major focus is on determining talent strategies that best companies use to attract and retain people. For the project, Deloitte has been chosen as the reference organization for the strategies it uses and how its human resource management has been able to sustain attracting and retaining good talent.

Zamzam abdelazim

It is the goal of every company to gain the most from investment in advertising. Contrary to conventional wisdom that sustained spending in advertising is needed to maintain high levels of sales, the concept of marketing persistence suggests that short term advertising campaigns can have long-lasting impacts on sales. This study offers impact of TV advertising on choice of consumer durable goods in Coimbatore District through the use of a marketing. Significant marketing persistence was found in sales of consumer durables. Based on the findings, implications for long-term marketing resource deployment are suggested.

Dr.n.s.lissy

Analgesic activity on two Cleome scaposa and Cleome brachycarpa by applying pressure-induced pain model

Dr. salman ahmed

Tremendous growth has been incorporated in the field of composite materials in the current scenario where the engineering applications are highly demandable. Currently composites are being used to replace conventional metallic materials in a wide range of industries including aerospace, defense, aircraft, and textile which require structural materials with high strength-to-weight and stiffness-to-weight ratios. Also natural fiber composites are currently replacing synthetic fiber composites of different applications in various engineering industries due to their low cost and eco-friendly in nature. In this work, twisted kenaf, and twisted kevlar (aramid fibers) have combined together to enhance the mechanical properties and also to improve high impact resistance with less contribution of kevlar which is very high in cost categorized next to carbon fibers. Here, the hybrid composites (natural and aramid) are done by using hand layup method, and various mechanical properties have been investigated. Also, the morphological analysis is done to observe the internal structure of the tested composite. It is observed that hybrid composite has high strength with minimum contribution of kevlar fibers.

Boopathy govindarajan

Foreign bodies (FBs) in the scalp are a common incident following head trauma, especially in traffic accidents, and are detected in the early post-traumatic period. The persistence of these FBs may cause pain and paresthesia. We report a case of 41 years old man, whose victim it’s been 20 years of physical aggression, in which the victim was hit by a brick occasioning a frontal wound stitched at the time without sufficient exploration. Months later, the patient presented several episodes of a frontal scalp nodular lesion with pus leakage (Fig. 1). The lesions were only treated with local antibacterial agents. Four years before the patient consults at our level, he consulted a dermatologist who performed a removal of the skin lesion. Months later, the lesion reappeared. At our level the clinical examination suspected a bone lesion, so CT was performed. Brain imaging was strongly evoking bone tumors or osteitis (Fig. 2). The patient was operated on under general anesthesia. First, a carcinogenic removal of the scalp lesion was performed; then, when reaching the bone, hard red friable bodies well separated from proportionally healthy bone were found. Those findings raise suspicion of the presence of FBs nested in the bone from the first head trauma. Hence, a carcinologic removal of the affected bone was postponed, and simple curettage was performed (Fig. 3). The post-operative course was without complications. The histological study confirmed per-operative findings: Multiple stony FBs associated with inflammatory reaction especially lymphocytes around vessels and the FBs.

Karishma