The present study focused on analysing the impact of ‘Make in India’ campaign on FDI inflows in country. The research period is divided in two parts one is pre ‘MII’ & another is post ‘MII’ period. The analysis of ‘Make in India’ campaign is done to identify the scope of the campaign & methodology of working of various allied departments monitoring campaign. The present research work also attempted to take overview of various policy reforms initiated by Government of India to promote the FDI as well domestic investment in 25 sectors shortlisted under MII. The FDI inflows statistics reveals that, the post MII period is showing the highest growth in FDI equity inflows as compare to same period i.e. 2009- 2014. The MII initiative is one of the reason for the jump in FDI inflows. The overview of policy reforms shows that GOI through DIPP attempted to open almost all sectors for 100% FDI through automatic route. Government has provided multiple incentives for Foreign Investors to establish their manufacturing facilities in country but very negligible response has been seen in the nature of FDI equity inflows in the same period. Further results of study reveals that multiple ‘MOU’s have been signed by States & Central Governments, but they yet not converted in actual investments. The major reasons behind the same is lack of SWOT analysis through Governments before inviting the foreign investors. As well lack of basic infrastructure, land, lack of skilled manpower, cheap & un interrupted power supply to MIDC’s & SEZ’s is yet not successfully provided, lower rankings in Ease Of Doing Business (EODB), Global Manufacturing Competitiveness Index (GMCI) is also cause of concern & tumbling block in the success of MII mission..
Keeping an in depth tab of recent folks or folks on chair with bound health conditions for his or her health and safety is a very important task. With maturity, weak bones and weakness because of alternative health connected problems could lead to will increase risk of falling. A supervisor might not continually be on the market with them and if correct assistance is not provided at the correct time it should cause larger health considerations which will need extra resources for treatment. For this purpose we've projected a wise IOT Fall Detection System exploitation acceptable sensors that square measure integrated facilitate|to assist} report these incidents to assist avail help at the correct time to forestall additional injury to health. The same system uses sensors like associate degree measuring system to live the speed of the person, a rotating mechanism to live the person’s orientation so as to live their stability, a load sensing element once the system is employed by an individual employing a chair to live their weight, a Wi-Fi module and a microcontroller that sends the general readings to alert the involvedthose that shall give with the right suggests that to assist the person in want. The microcontroller receives all the info from the sensors and perpetually transmits and monitors the acceleration and also the orientation of the person. Any fast abrupt modification within the system which will result from a fall is taken into account as a ‘fall’ and is reported . a serious concern would be that not all fast movement may end up from a fall and be thought of as a matter of concern. To avoid this warning a napbutton is provided to snooze the system. This button will be ironed before a definite time say 15-30 seconds to prevent the system from causation the alert, thus avoiding any confusion and panic. this method will be mounted to the person’s chair or will be created compact to be created into a wearable device which will be worn on the hand.
The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.
ABSTRACT Macrotyloma uniflorum, commonly known as horse gram, is an underused pulse that holds great potential as a supply of nutrition and functional compounds. This review paper aims to provide a comprehensive overview of the nutritional composition, Pharmacological activities, health benefits, and potential applications of Macrotyloma uniflorum. Horsegram has a high amount of protein, dietary fibre, and a variety of vital minerals and vitamins that make up its nutritional profile. Horsegram also has a high content of antioxidants, flavonoids, and phenolic compounds, all of which contribute to its potential health advantages. Horsegram intake has the potential to help manage a number of chronic conditions, including diabetes, obesity, cardiovascular problems, and gastrointestinal disorders, according to many studies. The review investigates the possible health advantages of Macrotyloma uniflorum, emphasising its function in controlling blood sugar, managing weight, lowering cholesterol, and antioxidant activity. Horse gram's medicinal potential is further increased by the presence of bioactive substances that include anti-inflammatory, antibacterial, diuretic, antiobesity, analgesic, anaphylactic action, and anticancer activities. In conclusion, this review paper presents a comprehensive evaluation of Macrotyloma uniflorum, highlighting its nutritional composition, health benefits, and potential applications. The findings underscore the significance of horse gram as a valuable functional food ingredient and encourage further additional investigation of its therapeutic properties for human health and well-being.
La lecture de toute production romanesque signée d’une Africaine, laisse souvent transparaître a priori l’idée qu’elle évoque la victimisation de la femme par la gent masculine. Mais, à certain niveau, l’univers de sa fiction n’affiche pas de façon catégorique ou formelle cette question. Tel est le cas de Fatou Diome avec son roman en cours de décryptage. Le but de cet article est de montrer que l’auteure construit son texte autour de plusieurs facettes pour assurer la transmission des valeurs identitaires et que le choix de certains genres oraux et l’évocation de la problématique de genre (homme-femme) offrent des concepts qui servent à exprimer des faits propres à l’identité culturelle africaine. À partir d’une analyse thématique et sociocritique, nous comprenons qu’elle adosse insidieusement à ce thème la problématique de l’identité. Ce, à partir de plusieurs artifices littéraires qui sont entre autres le potentiel oral traditionnel du terroir et le discours revalorisant la femme, par ricochet l’identité africaine.
Urolithiasis has been a common problem for centuries and has a high recurrence. This review aims to provide comprehensive information about traditionally used antiurolithiatic plants and their scientifically proven pharmacological activities like analgesic, anti-inflammatory, antioxidant, astringent, demulcent, diuretic, litholytic, lithotriptic, antiurolithiatic, antispasmodic, ACE inhibition and Phospholipase A2 inhibition as a plausible mechanism of action. A total of 503 species, 365 genera and 119 families were cited for treating kidney stones. The most cited families are Asteraceae (41), Fabaceae (34), Lamiaceae (26), Apiaceae (21), Rosaceae (19) and Poaceae (16). The most commonly used plant parts are root and rhizome (25%), mode of preparation decoction (62%), and oral administration route in all cases. This review will provide the opportunities for the future research and development of new natural antiurolithiatic compounds.
Monkeypox, an infectious disease caused by the Orthopoxvirus, was identified in humans in 1970. It has recently emerged as a global health concern due to outbreaks beyond its endemic regions in Central and West Africa. This review examines the current state of medical treatments for monkeypox as of 2024, focusing on antiviral agents, immunotherapies, and supportive care measures. Monkeypox manifests with symptoms including fever, rash, and lymphadenopathy, with severe cases more common in immunocompromised individuals. Antiviral therapies such as tecovirimat and brincidofovir are central to treatment strategies, with tecovirimat demonstrating efficacy in alleviating symptoms and reducing viral shedding. Emerging treatment strategies involve novel lipid-based formulations and combination therapies that integrate antivirals with immune-modulating agents. Supportive care remains essential, involving analgesics and antibiotics for secondary infections, while the MVA-BN vaccine plays a critical role in prevention. Research emphasizes the need for a deeper understanding of viral pathogenesis and host immune responses to improve therapeutic and preventive measures. Despite significant advancements, challenges remain, including potential antiviral resistance, disparities in healthcare access, and the necessity for enhanced diagnostic and surveillance capabilities. This review highlights the imperative for ongoing research, international collaboration, and investment in healthcare infrastructure to advance the management and prevention of monkeypox and to prepare for future outbreaks.
Mediterranean journal of pharmacy and pharmaceutical sciences
A simple, precise, accurate, sensitive, specific and reliable stability indicating RP-HPLC method was developed for the simultaneous estimation of Miconazole (MIC) and Ornidazole (ORN) in pharmaceutical dosage form. The method was developed with mobile phase containing buffer (0.05M potassium dihydrogen ortho phosphate, ph3.5): Methanol in the ratio of 25:75, C18 (250 x 4.6mm, 5µm) as a stationary phase and flow rate was 1 ml/min. Detection was carried out at 236nm in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Miconazole and Ornidazole at 6.58 and 3.26 min respectively. The proposed method has been validated for precision, accuracy, robustness. Thus, the statistical analysis confirms that developed methods were successfully used for analysis of formulation and thereby can be used for routine analysis of drugs in Quality Control laboratories.
Pendidikan agama Islam sebagai upaya mengembangkan, mendorong serta membimbing peserta didik hidup lebih dinamis dengan berdasarkan nilai-nilai agama islam dan terbentuk pribadi peserta didik insane kamil. Rumusan dalam dalam peneltian ini: 1) Bagaimana peran PAI dalam pembinaan kesehatan mental siswa di SDN Sekarputih 1 Tegalampel Bondowoso? 2) Bagaimana peran PAI dalam pembinaan kesehatan pikiran/intelektual siswa di SDN Sekarputih 1 Tegalampel Bondowoso? Metode penelitian ini menggunakan pendekatan kualitatif deskriptif dan jenis penelitian studi kasus. Metode pengumpulan data dengan metode observasi, metode wawancara dan metode dokumentasi. Sedangkan analisis data menggunakan model analisis interaktif Milles, Huberman dan Saldana dengan tiga Langkah dalam proses analisis data yaitu: kondensasi data, penyajian data dan penarikan kesimpulan. Untuk memeriksa keabsahan data ini, menggunakan tehnik triangulasi yaitu triangulasi tehnik, triangulasi metode dan triangulasi data. Berdasarkan hasil penelitian ini dapat disimpulkan: (1) Peran PAI dalam pembinaan kesehatan mental siswa di SDN Sekarputih 1 Tegalampel Bondowoso yaitu: (a) Agama sebagai pembimbing dalam kehidupan peserta didik. (b) Agama sebagai penolong dalam menghadapi kesulitan untuk memecahakan masalah yang di alami siswa. (c) Agama sebagai penentram bathin. (2) Peran PAI dalam pembinaan kesehatan intelektual/kesehatan pikiran di SDN Sekarputih 1 Tegalampel Bondowoso yaitu: (a) Guru membimbing peserta didik secara akademis di dalam sekolah maupun di luar sekolah. (b) Kajian-kajian keagamaan oleh guru PAI sebelum atau sesudah mata pelajaran dimulai. (c) Membudayakan siswa untuh silaturrahim kerumah guru. (d) Bimbingan secara intelektual kepada dengan teori-teori keagamaan yang memadai, agar siswa tidak sekuler dalam berperilaku sehari-hari.
Pumping fluid is one of the crucial parts of any microfluidic system. Using electric and magnetic fields as a substitute for moving parts can have many advantages. In this study hydrodynamic and heat transfer characteristics of electroosmotic flow under influence of lateral electric and transverse magnetic field, are studied numerically. Results indicate that the dimensionless parameters such as Hartmann number, intensity of the lateral electric field, pressure gradient parameter and aspect ratio have an important role in controlling flow. It can be implied that the enhancement of pressure gradient leads to the decrease of critical Hartmann number, and this dependency can be reduced from 44% to 7% for S=0.5 to S=50 in two pressure gradients of Ω=1 and Ω=20. In addition, the reduction of aspect ratio of microchannel section leads to the increment of critical Hartmann number in a specified lateral electric field. At the end, thermal analysis is being done by consideration of the effects of magnetic and electric fields on the Nusselt number.
This study investigated the level of environmental citizenship development through curriculum development planning among primary school pupils in Rivers State. Three research questions and two hypotheses guided the study. The descriptive survey design was used. The population for the study was the 15,611 teachers in the 962 public primary schools in Rivers State. A stratified random sampling technique was used to draw a sample of 1,600 teachers which represents 10.2% of the population. A researchers’ designed questionnaire titled "Curriculum Development Planning in Environmental Education Questionnaire" was the instrument used for the study. The instruments were validated by three experts. Reliability coefficients of 0.88 (Curriculum Provision), 0.73 (Environmental Education Projects), and 0.79 (Challenges) were derived using Cronbach alpha. Mean and standard deviation was used to answer the research questions while the hypotheses were tested using the z-test. Findings revealed that the extent to which environmental education projects were utilized to develop environmental citizenship in pupils is low. The challenges militating against the teaching of environmental education are lack of commitment from the school management, lack of time in the lesson timetable to integrate environmental education contents in other subject areas, and teachers' inadequate knowledge of environmental education integration techniques. It was recommended amongst others that the Nigerian Education Research and Development Council should design age-appropriate curriculum contents/topics that can be integrated into various subjects.
The study employed Appreciative Inquiry framework to have an in-depth investigation in the personal lives of the participants and to draw connections between their beliefs and practices in taking Licensure Examination for Teachers and how these superstitions reflect and affect their moral principles. Specifically, it aimed to: (1) determine the superstitious beliefs followed by the examinees before, during, and after taking the Licensure Examination for Teachers (LET); (2) determine the positive and negative impact of these superstitions in the aspect of taking LET; and, (3) identify the effects of these superstitions in the characters and principles of the teachers. Semi-structured interview and focus group discussion were used and the data-sources were triangulated to come-up with a stronger analysis. Audit trail and member checking were followed to ensure that there were no biases in the interpretation of the data and to establish the validity of the results. Findings revealed that the student examinees followed different superstitious beliefs before, during and after the exam which have positive and negative effects. The motive of avoiding failure in the examination predominates over the motive of achieving success. The positive and negative effects of superstitions vary from one person's experience to another. Moreover, the assertion and personal disposition to pass the exam became the product of student examinees' projection. The superstitious notions were initiated to discard the student examinees' fears and to safeguard their emotional sphere against negative feelings and any untoward possibilities. Meanwhile, in the development of moral principle, the student examinees' family, peers and the society are important factors in the establishment of their belief system which later on reflects the moral principles they uphold.
2-Azetidinone shows biological activities like anti-bacterial, anti-microbial activity, anti-tubercular activity, and anti-cancer activity. 2-azetdinone derivatives were synthesized by simple procedures. The first step is synthesis of benzohydrazide through nucleophilic substitution reaction between methyl benzoate and hydrazine hydrate. The above formed compound is then treated with substituted aromatic aldehydes in the presence of catalytic amount of concentrated hydrochloric acid with stirring for one hour to give benzohydrazone which results in the formation of Schiff bases.Schiff bases undergone cyclisation in the presence of chloroacetylchloride and diethylenediamine by using ethanol as a solvent upon stirring for 4 hour’s yielded 2-azetidinone derivatives. The in-silico anti-leukemic activity was determined by using the computational tools i.e. “PASS Online”, “AutoDock4.2” and “ADMET” properties by online software’s. Among these six derivatives compounds (AZT-6) was shown more activity when compared with the other five compounds.
The very first recruitment for a public relations practitioner in Malaysia was encountered in 1948 and was advertised by the federal government of the British Colony in Malaya. This paper examines the subsequent advertisements after Malaya sought independence from the British colonial government. A total of eleven recruitment advertisements were found before the formation of Malaysia on the 16th September 1963. This paper outlines the advertisers, the titles of positions, as well as their qualifications and duties. The results show that the job requirement mainly came from the federal and local governments. Generally, the duties were related to information services and some specific responsibilities.
This paper compares different optimizable machine learning classification models to predict eight types of anemia from complete blood count (CBC) data. For the research, we used a publicly available Kaggle dataset containing 1281 observations, 14 predictors, and the diagnosis as the categorical target variable with nine categories (eight types of anemia and the healthy category). First, we examined the dataset and observed the histograms of some of the predictors. We compared the values of predictors of observations with no anemia to the observations where any anemia was diagnosed. Next, we used MATLAB R2024a to train and test nine optimizable machine-learning classification models. These models were Ensemble, Tree, SVM, Efficient Linear, Neural Network, Kernel, KNN, Naïve Bayes, and the Discriminant. Bayesian optimization was used to optimize the hyperparameters of all these models. We used 90% of observations for training and 10% of observations for testing. During the training, 10-fold cross-validation was used to prevent overfitting. The results showed the best accuracy was reached with the Ensemble classification model using the bag ensemble method (validation accuracy: 99.22%, test accuracy: 100%). Finally, we inspected our best classification model in more detail. We calculated the permutation feature importance to determine the contribution of each predictor to the final model. The results showed 6–7 important predictors, while the most important feature was the amount of hemoglobin.
Vigna aconitifolia (Jacq.) Marechal. (Papilionaceae) is a medicinally important plant used for treating different diseases, especially dermatological disorders. Alkaloids, phenols, flavonoids, and phytic acid have been reported in this plant. Vigna aconitifolia also exhibits antioxidant, antidiabetic, and hypocholesterolemic activities. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.
The study identified the level of competencies and the extent of professional development needs of kindergarten teachers in the Sultan Kudarat Division, during the school year 2019 - 2020. The study employed a descriptive method. The study involved 54 kindergarten teachers in the division in accomplishing the 12-item self-assessment instrument. Data were analyzed using descriptive statistics. The results revealed that kindergarten teachers have a high level of competencies in content knowledge and pedagogy, learning environment and diversity of learners, curriculum and planning, and assessment and reporting. These indicate that they possess almost all of the competencies of efficient teachers. Results further revealed a very high extent of professional needs in content knowledge and pedagogy and the learning environment and diversity of learners, while they had a high extent of professional needs in the remaining domains. Since they reported very high priorities in content knowledge and pedagogy and the learning environment and diversity of learners, these areas would be the main considerations in the crafting of a professional development plan.
Carica papaya leaves are a popular remedy to treat Dengue-induced thrombocytopenia. There have been reports of Carica papaya effects as antibacterial, anti-parasitic, anti-cancer, and anti-inflammatory. There is limited evidence documenting the effects of Carica papaya on increasing platelet count in relation to Dengue infection. Moreover, the mechanism by which Carica papaya increases the platelet counts has not been elucidated. Understanding how Carica papaya affects platelet function may have implications beyond Dengue fever management. This study aims to investigate the mechanism by which Carica papaya affects platelet count. The mechanism of thrombocytopenia in the aqueous and methanol extracts was elucidated by measuring reactive oxygen species in platelets using chemiluminescence. Both aqueous and methanol extracts of Carica papaya leaves were found to increase reactive oxygen species levels in vitro. This study is the first to try to demonstrate the mechanism by which Carica papaya increases platelet count. Carica papaya leaves may be developed into novel and useful therapeutic agents in the management of thrombocytopenia-related disorders and cardiovascular diseases.
Mediterranean journal of pharmacy and pharmaceutical sciences
Numerous initiatives to rely on new renewable energy sources, such solar electricity, have been sparked by the increased interest in global warming. With an increase in home photovoltaic (PV) panels that are available to the public, more precise calculations of energy generation are now possible. Segmenting satellite images offers a straightforward and inexpensive way to categorize solar panels..This work suggests a method for classifying and segmenting solar panels that combines the watershed algorithm with deep learning approaches. First, a Convolutional Neural Network (CNN) architecture with the ResNet, EfficientNet, and Inception architectures is used for classification. Through the fine-tuning of pre-trained networks on a heterogeneous dataset of solar panels, transfer learning improves performance. The categorization model recognizes solar panels in a variety of settings with accuracy, making maintenance and monitoring easier. After classification, the watershed method uses intensity gradients to precisely delineate solar panels from the background. Tasks like defect detection and layout optimization are made easier when deep learning-based classification and watershed segmentation are combined. The outcomes of the experiments show how well the suggested method performs in terms of segmenting and classifying solar panels under various circumstances. A flexible automated solar panel management solution is provided by the combination of deep learning and the watershed algorithm, which promotes increased sustainability and efficiency in solar energy systems.
It is virtually impossible to mention the phrase ‘project management’ without introducing the concept of risk management. As Hillson (2016, p.11) states, “risks [are] particularly relevant to projects” suggesting that effective management of risk is an integral ingredient for project success. The close link that exists between projects and risks may be deduced by the definition of the word ‘project’. In simple terms, projects refer to unique endeavours undertaken with the aim of achieving desired outcomes. These endeavours typically specific start and completion dates, and involve resource, time and cost constraints. These characteristics imply that projects are intended to deliver identifiable benefits to the organisation; these benefits, however, are not enjoyed immediately even if the project is completed. On the contrary, projects commonly create capabilities that call for operation or utilisation for the actual gains to be generated (Hillson, 2016 p.11). The interpretation of this is that projects have a risk element in that they contain a potential reward and possibility of loss. For this reason, project managers must be well-versed with risk management.