Patent foramen ovale (PFO) is a prevalent congenital cardiac anomaly. It is increasingly acknowledged as a significant factor in cryptogenic ischemic stroke, especially among young adults experiencing otherwise unexplained cerebrovascular incidents. This review summarizes recent advances in the epidemiology, pathophysiology, diagnostic strategies, and management of PFO-related stroke. The article examines the intricate mechanisms of PFO-associated strokes, including paradoxical embolism, in situ thrombus formation, and atrial cardiopathy, while emphasizing the significance of anatomical risk factors like large shunt size and atrial septal aneurysm. The clinical implications of PFO in various disorders, such as migraine with aura, decompression sickness, and high-altitude pulmonary edema, are also analyzed. Diagnostic modalities such as echocardiography and transcranial Doppler are compared, focusing on their sensitivities and procedural details. The review focuses on evidence-based methods for medical, interventional, and device-based closure of PFO, highlighting patient selection and ongoing controversies. The ongoing uncertainties surrounding causal relationships, risk stratification, and optimal therapy highlight the necessity for continued research. This review offers a current synthesis for clinicians and researchers addressing the challenges associated with the evaluation and management of PFO in stroke prevention. To achieve the aims of the article and make it concise, PubMed, Google, EMBASE, Google Scholar, and Scopus were searched for original and review articles published in the last 10 years. Several keywords, phrases, and texts were utilized.

Karishma

Freeze desalination (FD) is a method in which saline water is cooled below its freezing point and freshwater is separated from the brine in the form of ice crystals. FD is relatively insensitive to the salinity of the feed solution, making it suitable for desalination of high concentration brines such as the brine rejected from the seawater desalination plants. The design of the FD system and the thermochemical behavior of the brine upon freezing are critical factors in the energy performance of this method. To date, thermochemical properties of the concentrated seawater during cooling, such as the threshold of formation of ice and salt-hydrates and their corresponding cooling load of formation, are not well known. Likewise, the optimal configuration of the FD system to achieve the maximum energy efficiency has not been investigated. This work provides comprehensive data about the cooling load of freezing of concentrated brine rejected from seawater desalination plants along with the threshold of formation of ice and salt-hydrates backed-up by validation. Furthermore, the optimal configuration of the FD system is identified and the effects of the compressor isentropic efficiency and effectiveness of the system’s heat exchangers on the work consumption of the FD system were investigated.

Aly elhefny

The main focus of this paper is to examine the relationship between insecurity in Nigeria and how traditional institutions such as traditional monarchical system can be used as veritable tool to curtail increasing insecurity in a democratic system such as Nigeria. The pervasive nature of insecurity,though,not an entirely Nigerian problem, has been trending of late, andhence, become a huge source of worry for scholars,experts,public commentators and the international community at large.The menace of insecurity finds expression in wanton killings, kidnapping,farmers-herders conflicts, rape, communal clashes, militia activities, ethnic secessionist agitations and many other strands of violence. The multiplier effects of all these challenges have been very devastating in terms of the recent attacks witnessed all over the country in recent times. This study observes that most of the people engaged in some of these atrocities might be well known to traditional rulers in the communities where they come from. This is because traditional rulers are closest to the people. The work is an exploratory study and relies solely on literature and works of experts in the broader field of security studies for investigation. The paper sums up a conclusion and recommends that there is a need for the adoption of both vertical and horizontal approaches to tackle the menace of insecurity, particularly, using the instrumentality of traditional institutions as a point of departure.

Canice erunke

Introduction: Obesity has been declared an epidemic that does not discriminate based on age, gender, or ethnicity and thus needs urgent containment and management. Since the third wave of COVID-19 is expected to affect children the most, these children and adolescents should be more cautious while having junk foods, during covid situations due to the compromise of Immunity in the individuals and further exacerbating the organ damage. Methodology: A PAN India survey organized by the Centre for Science and Environment (CSE) among 13,274 children between the ages 9–14 years reported that 93% of the children ate packed food and 68% consumed packaged sweetened beverages more than once a week, and 53% ate these products at least once in a day. Almost 25% of the School going children take ultra-processed food with high levels of sugar, salt, fat, such as pizza and burgers, from fast food outlets more than once a week. Children and adolescents who consume more junk food or addicted to such consumption might be even more vulnerable during the third wave, which will significantly affect the younger category. Conclusion: There is an urgent need to spread awareness among children and young adults about these adverse effects of junk food. There is no better time than now to build a supportive environment nurturing children and young adults in society and promising good health.

Ankul singh

Nuclei segmentation plays an essential role in histology analysis. The nuclei segmentation in histology images is challenging in variable conditions (clinical wild), such as poor staining quality, stain variability, tissue variability, and conditions having higher morphological variability. Recently, some deep learning models have been proposed for nuclei segmentation. However, these models rarely solve the problems mentioned above simultaneously. Most of the information in Hematoxylin and Eosin (H&E) stained histology images is in its channel, and the remaining information is in the spatial domain. We observed that most problems could be solved by considering channel and spatial features simultaneously, e.g., the spatial and channel features provide the solution to the morphological variability and staining variability, respectively. Therefore, we propose a novel spatial-channel attention-based modified UNet architecture with ResNet blocks in encoder layers. The UNet baseline preserves coarse and fine features, thus proving the solution to the tissue variability. The proposed method significantly improves the segmentation performance compared to the state-of-the-art methods on three different benchmark datasets. We demonstrate that the proposed model is generalized for 20 cancer sites, more than any reported literature. The proposed model is less complex than most state-of-the-art models. The impact of the proposed model is that it will help improve further procedures such as nuclei instance segmentation, nuclei classification, and cancer grading.

Ibtihaj ahmad

Background: Infantile hemangioma (IH) is observed at varying frequencies among children, impacting 10% of infants. The majority of uncomplicated IH cases experience spontaneous involution, while a minority necessitate intervention. This study aimed to assess the safety and effectiveness of propranolol in treating IH in Libyan pediatric patients. Methods: From 2013 to 2016, a total of 100 patients diagnosed with infantile hemangioma (IH) were monitored at a pediatric tertiary hospital's hematology clinic. Their demographic and clinical information, along with digital images of the lesions, were collected prospectively to evaluate coloration, size, and improvement of the hemangioma lesions. Following parental consent to initiate treatment, a regimen of oral propranolol, atenolol, or a combination of propranolol and steroids was commenced. Results: The study included 100 children diagnosed with infantile hemangioma (IH), consisting of 62% females and 38% males. Out of these, 68 children were treated exclusively with propranolol, while 12 were started on atenolol. The remaining 20 children received a combination of steroids and propranolol. Hemangioma lesions were primarily located on the face (56%). After an average follow-up duration of 10.53 ±7.21 months, among the 68 children treated solely with propranolol, 12 under the age of 12 achieved complete resolution of their hemangiomas, 15 demonstrated near-complete resolution, and the remaining 41 showed a significant reduction in hemangioma size without considerable disfigurement. Following a six-month discontinuation of propranolol, 2 children from this group experienced a relapse of their lesions. In one instance, the lesion resolved after 12 months of resuming propranolol, while the other required 18 months of treatment. Among the children treated with atenolol, two attained complete resolution, two had near-complete resolution, and 8 exhibited a significant reduction in hemangioma size. No relapses or changes in lesion size were noted after the cessation of atenolol. Conclusion: Oral propranolol is considered both safe and effective for the treatment of IH at a daily dosage of 2 mg/kg, with no significant adverse effects reported. Atenolol serves as an alternative to propranolol, while steroids, despite their potential side effects, have been shown to improve lesions in certain pediatric patients. Nevertheless, further large multicenter studies are necessary.

Karishma

By January 2020, severe acute respiratory syndrome coronavirus-2 has spread internationally to a pandemic that mainly targets the respiratory system. The relevant infectious disease has been identified as coronavirus disease-2019 (COVID-19) by World Health Organization and declared as a global pandemic. In Libya, National Center for Disease Control reported the first case of coronavirus disease-2019 on 24th March, 2020. The authorities decided to close borders and activate designated treatment centers to deal with COVID-19 cases and contain the outbreak of SARS-COV-2. This study aimed to assess and evaluate the pharmaceutical situation of medications used in pharmacological management of hospitalized COVID-19 patients in Tripoli, Libya. Three WHO availability indicators were selected to be studied and reported. A comprehensive list of medicines used in the management of hospitalized COVID-19 patients was constructed after reviewing and comparing seven national and international pharmacological management protocols and guidelines for hospitalized COVID-19 patients. This comparison revealed that nearly 50 medications are intended for use in COVID-19 inpatient pharmacological management. They all agreed about the use of three medications, representing one from each main class. This list was used to cross check their availability at the chosen designated COVID-19 treatment center. This study proved that local treatment center’s protocol is more in line with international guidelines than the national treatment guideline. The later was issued on March 2020. The Libyan National Essential Medicines’ List contained 25 out of 50 medications of the comprehensive list based on the last update in April 2019. This study recommends that national treatment guidelines and National Essential Medicines’ list require updating. Not all medications used in COVID-19 inpatient management were available in local treatment centers, although, the Emergency Management Department of Ministry of Health in Libya is responsible for the supply of the required medical supplies and medications to the COVID-19 treatment centers.

Mediterranean journal of pharmacy and pharmaceutical sciences

This study was carried out to evaluate the effects of thermal processing techniques on the nutrient and antinutrient contents of pigeon pea (Cajanus cajan) flours. The pigeon pea seeds were sorted, cleaned and divided into five equal lots of 0.5kg each. Four lots of pigeon pea seeds were processed into blanched, boiled, roasted, and autoclaved pigeon pea flours, while the fifth lot was processed raw and used as control. The raw and thermally processed samples obtained were analysed for nutrient and antinutrient composition using standard methods. The proximate composition of the samples showed that the flours had a range of 8.61 - 11.46 % moisture, 21.13 - 23.94 % crude protein, 1.26 - 1.68 % fat, 5.12 – 6.10 % crude fibre, 1.74 – 2.97 % ash, 55.56 – 60.41 % carbohydrate and 333.45 - 342.75 kJ/100g energy, respectively. The mineral composition showed that the flours contained 86.24 – 144.72 mg/100g calcium, 137.80 – 170.33 mg/100g magnesium, 125.86 - 156.76 mg/100g potassium, 66.66 – 95.62 mg/100g sodium, 4.38 – 6.64 mg/100g iron and 130.27 – 178.29 mg/100g phosphorus, respectively. The vitamin content of the flours were 3.09 - 4.33 mg/100g ascorbic acid, 0.05 - 0.17 mg/100g thiamine, 0.03 - 0.21 mg/100g riboflavin, 0.13 - 0.28 mg/100g niacin, 3.21 - 6.25 mg/100g vitamin A and 1.10 - 2.70 mg/100g vitamin E, respectively. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor, tannin, phytate, oxalate, saponin and haemagglutinin ranged from, 2.30 – 5.61 Tiu/mg, 0.81 – 1.5mg/100g, 1.12 - 4.18mg/100g, 0.48-4.01 mg/100g, 1.28 – 3.66 mg/100g and 1.30 – 7.44 Hiu/g, respectively. Therefore, the study showed that thermally processed pigeon pea flours could be used as nutrient dense ingredients in the preparation of a wide range of foods for children, adolescents and aged adults especially in developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent than the raw sample.

Okechukwu obed chukwuemeka

Bone resorption is created by different etiological factors, such as tumors, infections, and trauma. When defects are too large and healing is not possible in a spontaneous way, the defect is called a critical size defect, which is defined as the smallest size of an intra-osseous wound that will not heal spontaneously during the lifetime of the individual. This study was conducted to evaluate the use of a mineralized plasmatic matrix versus bone graft alone or in the augmentation of bony cavities in animals. Ten adult male dogs ranging in age from 12 months to 18 months with a mean weight of ten kilograms were used in this study. Bone cavities were made in the tibia of each animal. The upper holes were implanted with a bovine bone material substitute the medial holes were implanted with a mineralized plasmatic matrix and the lower holes were left free from any implant material acting as control. The dogs were euthanized at 2, 4, and 6 weeks and prepared for H and E stain and trichrome stain. The healing process of bone cavities implanted with mineralized plasmatic matrix was better compared to cavities filled with bone grafts and those left to heal spontaneously. Mineralized plasmatic matrix facilitates graft application, in its stabilization, and improves cell penetration into the graft.

Mediterranean journal of pharmacy and pharmaceutical sciences

The planned opening of foreign universities will foster cultural exchange, expose Indian students to diverse perspectives and promote international understanding, according to Gedam Kamalakar. Foreign university campuses have the potential to attract foreign investment, create job opportunities and stimulate the local economy through increased spending on infrastructure, accommodation and services. Partnerships with foreign universities on joint research projects will enhance knowledge exchange and technological advancements. Nevertheless, the influx of foreign universities can pose a threat to domestic educational institutions by alienating talented students and faculty and exacerbating inequalities in access to quality education. There is hence a danger of cultural imperialism. Indigenous knowledge and traditions may be marginalised due to the dominance of Western educational systems and values. Increasing opportunities to study abroad may also increase brain drain.

Dr gedam kamalakar

Aminopyrine (AM) has been used as a model substrate for investigation of drug metabolism. The major metabolic route is N-demethylation that was confirmed in liver microsomes. The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating the N-demethylation of 4-di-methylaminoantipyrine (4-DMAA) to 4-methylaminoantipyrine (4-MAA). The contribution of human CYP to the metabolism of (4-DMAA) to (4-MAA) in human was investigated using virus expressed human CYP, human liver microsomes with chemical inhibition studies. The substrate of 4-dimethylaminantipyrine was employed at different concentrations (11.5, 23, 46, 115 and 230 µmol per l) with varying concentrations of selective inhibitors of CYP (CYP1A2), (CYP3A4), (CYP2C8),(CYP2A6), (CYP2D6), (CYP2C19) and (CYP1A1). 4-DMAA and 4-MAA were analysed by HPLC and enzyme kinetic parameters (Km and Vmax) were calculated from the concentration data. The transformation of 4-dimethylaminoantipyrine to 4-methyaminoantipyrine by microsomes prepared from baculovirus-expressed human CYP was pronounced with CYP2D6. The metabolism of 4-dimethylaminoantipyrine was inhibited by 60.0% and 55.17% by a concentration of 100 µmo per l of the known CYP2D6 inhibitors quinidine and moclobemide. The corresponding Ki values were 0.050 and 0.11 mM, respectively. The corresponding IC50 values were 0.06 and 0.13 mM, respectively. The enzyme CYP2D6 apparently has an important role in N-demethyl-ation of 4-dimethylaminoantipyrine.

Mediterranean journal of pharmacy and pharmaceutical sciences

Women are multi taskers in their lives- mother, wife, daughter, sister and a lot more. And hence are exposed to a lot of emotions. A working woman is exposed to many other more roles- boss, subordinates. A working woman has to develop skills of self awareness, self management, be motivated, feelings of optimism, positivity and internality, empathy and social skills (collectively called as emotional intelligence) to perform her multiple roles, both at home and at, work place efficiently so as to meet the expectations of both the family members and their organization. Current study focuses on investigating the influence of demographic factors on the level of emotional intelligence among the respondents in Coimbatore city. These factors tested against being determined by their age, job profile, marital status.

Nandini

Hyperoxaluria is a metabolic disorder responsible for calcium oxalate nephrolithiasis. The study was conducted on glass slides to observe the growth patterns of urinary calcium oxalate monohydrate crystals and their inhibition by 5, 10, 15 and 20 % infusion of Macrotyloma uniflorum seeds. For this purpose, a drop of gel medium (sodium metasilicate of 1.06 specific gravity and 3M acetic acid solution) at pH 5.02 - 5.17 was placed in the middle of a glass slide and converted into a gel. A 1 M oxalic acid drop was dropped to the left, and 1 M calcium chloride and magnesium acetate (1:1) solution was dropped to the right side of the properly formed gel. The glass slide was observed under a microscope till it was completely dried. In the case of the crystal inhibition study, a drop of M. uniflorum infusion was also added on the right side just after adding calcium chloride and magnesium acetate solution. The results without infusion showed detailed morphology and aggregation patterns of observed crystals such as donut, dumbbell, needles, platy, prismatic, rosette, round edges, X-shape crystals, loose and compact aggregates. All infusions of M. uniflorum affected the crystals, forming defective crystals. 5 % infusion inhibited crystals of all morphologies except donuts, X-shaped crystals, donuts, platy crystals and rosettes. Defected rosettes were observed in 10 % infusion, which was reduced gradually in the crowd by 15 and 20 %, respectively. From this study, it can be concluded that M. uniflorum seeds infusion is effective against calcium oxalate nephrolithiasis.

Dr. salman ahmed

Self-medication with antibiotics is becoming a trend that threats the health systems worldwide through developing bacterial resistance which is associated with high health care costs and increased rate of morbidity and mortality. The main objective of this study is to assess antibiotic self-medication practice among Libyan university pharmacy students. This is a cross-sectional study conducted among pharmacy students at Sabratha University in the western region of Libya. A validated questionnaire was used to collect relevant data which were statistically analyzed. A total of 170 undergraduate Pharmacy students participated in the study during spring 2021. About 80% of the participants reported the use of antibiotics without consulting a physician. The major reason for using antibiotics was to get a quick relief of emergency conditions which was reported by 35% of the students. About 25% of the students used antibiotics to relieve their pains and aches. The most commonly used antibiotic was amoxicillin (55%). Most antibiotics were obtained over the counter from community pharmacies (85%). Half of the participants were not sure if they can advise patients to use antibiotics without a prescription, although 60% of them believed that it was good practice. In conclusion, prevalence of antibiotic self-medication among university pharmacy undergraduate students is high. Thus, serious interventions are required to ensure safe and effective use of antibiotics among the population in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

Indian Economy is the world's 06 th largest economy (2021 Nominal GDP) and 03 rd largest by purchasing power parity (2021 PPP). Salaried workers are a consistent group of tax paying citizens that give roughly 12% of overall revenue to a government through income tax. Due to which tax planning has assumed special importance for salaried individuals. All taxpayers in India have a variety of tax saving choices. These choices provide a variety of exclusions and deductions that help to reduce the total tax burden. Deductions are provided from Sections 80C through 80U, and qualifying taxpayers can claim them. Hence it is essential for the individual tax payer to know all their possible tax regulations and for tax compliance. It is totally legal and, in fact, a wise option when tax planning is done within the boundaries set by the relevant authorities. However the salaried individuals are not able to plan their taxes which results in opting for the wrong investment options. The objective of the study is to determine the level of awareness among the salaried individual on several tax planning methods offered on professional tax under the income tax act and to identify the factors influencing the tax planning behaviour of the salaried individuals..

Sabir mujawar

Dans notre système éducatif, l’accès à la formation pédagogique pour l’enseignement primaire est accessible aux personnes dotées du certificat de l’école primaire. Or, le système éducatif les plus performants organisent un dis- positif de pré-sélection afin de former les meilleurs pour assurer un enseigne- ment de qualité. Le recours à la théorie des intelligences multiples, est salutaire pour le recrutement des futurs enseignants dans notre système éducatif. A partir de cette théorie, la formation initiale des enseignants et leurs recrutements sont spécifiquement bordés de trois axes à savoir : interpersonnel, linguistique et lo- gique/mathématique, pourquoi mettre de côté les autres formes d’intelligences ? Or l’enseignant du primaire doit bénéficier aujourd’hui d’une formation totale.

Assanvo

WhatsApp is mobile application which allows exchange of messages, videos, audio’s and images via Smartphone. The increased use of IM on phones has turned to be goldmine for mobile and computer age. This paper focuses on understanding experimental viewpoint about the intensity, usage of whatsapp messenger and its impact on the academic performance of students in institutions. Instead of fast communication and enhancing effective flow of information and idea sharing among students, whatsapp has actually impacted in some pessimistic performance of students. For instance it takes up much of the students study time resulting in procrastination related issues , destroys students’ linguistic skills, leads to lack of concentration during lectures, results in difficulty in balancing online activities (whatsapp) and intellectual preparation and distracts learner from completing their assignments and adhering to their private studies time table. It is very userfriendly and easy to get initiated. Simply enter the telephone number of the device into the app. It then sorts through the contacts (with your permission) on the phone to figure out who else also has the app already installed. Users can then invite more contacts or go ahead and start sending messages to the ones that the app discovered. Brian Acton and Jan Koum (2009) invented Whatsapp messenger for easy and fast communication and distribution of multimedia messaging. Whatsapp is one of the trend and fashion in technology that is commonly used on specific mobile phones and computers. Since the Smartphones became popular, many messaging services were launched but Whatsapp has become widespread among them. The service is available free for one year and later user has to pay very less annual amount. Besides all, this Application is highly fanatic and can create a great impact on regular users, and apart from that it can leave a trace that becomes difficult to control and cure. With whatsapp messenger, communication through mobile phones has become easier, faster and cheaper. It is less expensive as compared to the normal phone messaging. An individual can chat with friends and family overseas through whatsapp without having to incur global SMS charges.

Sunita singh

Background: This manuscript presents an audit focused on assessing the extent of drug wastage and associated costs linked to the disposal of unused intravenous agents within the operating theatres of a tertiary care hospital. The study aims to carefully look at drug wastage, figure out why it happens, and propose strategies for optimizing resource utilization and cost-efficiency in clinical settings. Materials and Methods: This audit is a prospective observational study carried out in a tertiary care hospital. The amount of drug loaded preoperatively, the amount of drug utilized, the amount of drug unutilized and discarded, the total quantity of drug wasted, and the cost related to the wastage were calculated in percentage. Results: The maximum wastage of loaded drugs was seen with atropine (100%), followed by ephedrine (93.6%), propofol (52.5%), phenylephrine (35.2%), atracurium (28.6%), dexmedetomidine (27.8%), fentanyl (16.8%), vecuronium (16.2%) and morphine (6.4%). The cost analysis revealed that 36.3% of the total loaded drugs were wasted amounting to Rs.46903.54. The cost of wastage of propofol was maximum with Rs.14006 which is 29.8% of total cost wastage followed by atracurium 21%(Rs.9856), dexmedetomidine 18.4%(Rs.8687.5), ephedrine 14.7%(Rs.6919), phenylephrine 10.4%(Rs.4910), fentanyl 3.7%(Rs.1780), atropine 1.9% (Rs.906), vecuronium 1.2% (Rs.563.76), Morphine 0.18% (Rs.85.28). Conclusion: In our audit, the maximum drug wastage was observed with atropine (100%) amounting to Rs.906, and the cost of wastage was maximum with propofol amounting to Rs.14006 which was 29.8% of the total cost of wastage. Our audit underscores the importance of proactive management of drug wastage and disposal costs in healthcare settings, particularly within operating theatres where intravenous agents play a crucial role in patient treatment. By conducting a comprehensive audit and proposing targeted interventions, healthcare institutions can optimize resource utilization, enhance sustainability, and ultimately improve patient outcomes.

Kamal singh

Gaucher Disease (GD) is the most common lysosomal storage disorder. The prevalence of GD is approximately 1/100,000, and type III GD accounts for 5% of cases. [1] It is an autosomal recessive disease due to a GBA gene mutation, leading to glucocerebrosidase enzyme deficiency. [1,2] Gaucher disease (GD) is categorized into three types according to clinical presentation: [3] Type I, which is non-neuronopathic and most common, particularly among Ashkenazi Jews; Type II, which is acute neuronopathic and marked by significant neurological involvement and high mortality rates; and Type III, which is subacute neuronopathic, exhibiting both systemic and neurological symptoms. In this report, we discuss a 24-year-old man from Libya diagnosed with GD type III. His diagnosis was established at the age of one due to symptoms including pallor, poor appetite, and hepatosplenomegaly. Laboratory tests indicated a hemoglobin level of 5.6 g/dL, chitotriosidase activity of 18,742 μmol/L, and an angiotensin-converting enzyme level of 251 UI/L. Genetic analysis confirmed a homozygous L444P mutation. He underwent splenectomy at the age of three, and enzyme replacement therapy (ERT) was administered intermittently with regular follow-ups until 2011. In December 2023, the patient experienced two weeks of abdominal pain, distension, and fatigue. A physical examination revealed ascites, dilated abdominal veins, and an enlarged liver and spleen.

Karishma

The primary cause of many fatalities is hypertension (high blood pressure). Many hypertensive patients are not even aware that they have the condition. As a result, hypertension is sometimes referred to as a silent killer. Until the harmful effects of high blood pressure, such as myocardial infarction, stroke, renal abnormalities, and vision problems, are identified, hypertension is typically asymptomatic. Without the use of herbs and dietary control, conventional medication therapy could not be enough to treat hypertension. The growing number of persons with high blood pressure can be effectively treated using alternative medicine. Numerous alternative therapies, such as diet, exercise, stress management, vitamins, and herbs, have been proven to be effective in lowering high blood pressure. There are several medications available to treat this disorder however popular antihypertensive medications typically have a long list of adverse effects. Numerous active ingredients with pharmacological and preventative qualities found in medicinal plants can be used to treat hypertension. This review discusses an overview of important medicinal plants and phytochemicals with hypotensive or antihypertensive effects.

Mediterranean journal of pharmacy and pharmaceutical sciences