Neurological sicknesses are severe, multifactorial, debilitating disorders that may cause neurodegeneration. Neuroprotection protects the structure and capacity of neurons from affronts emerging from cell injuries instigated by an assortment of specialists or neurodegenerative diseases. Various neurodegenerative diseases, including Alzheimer's, Parkinson's, and epilepsy, afflict many people worldwide, with increasing age representing the leading risk factor. Crocin is a natural carotenoid compound with therapeutic potential in managing neurological disease. In this review, we focused on the therapeutic capabilities of Crocin as a neuroprotective agent. The general neuroprotective impact and the various conceivable essential components identified with Crocin have been examined. In light of the substantial proof indicating the neuro-pharmacological viability of Crocin to different exploratory standards, it is concluded that Crocin exerts direct antioxidant, antiapoptotic and anti-inflammatory activities by multiple signalling pathways. Besides, Crocin was found to elevate dopamine levels in the brain during the experimental model of Parkinson's disease. Thus, this compound has been demonstrated to be a promising option for treating neurodegenerative diseases with few adverse effects. It should be further considered as a potential contender for neuro-therapeutics, concentrating on the mechanistic and clinical evidence for its effects.

Dr. salman ahmed

As the demand for renewable energy continues to rise, it becomes crucial to discover effective ways to enhance grid-connected photovoltaic (PV) battery energy storage systems. The Institute of Petroleum Studies (IPS) complex at the University of Port Harcourt in Rivers State, Nigeria, embarked on a quest to determine the optimal approach for optimizing their PV battery energy storage system. This research aimed to fulfill this need by employing a diverse research methodology, incorporating the innovative MOALO theory. To begin with, the research gathered primary and secondary data to construct models for the power grid, solarPV, and battery. Furthermore, it meticulously analyzed the load profile of the IPS complex, at the University of Port Harcourt. Leveraging the power of the MOALO theory.The researchers accurately sized the system and evaluated the potential outcomes of simultaneously interconnecting all loads. To gauge the system's performance, there was a calculation of various parameters such as economics, random walk, boundary conditioning, entrapping ants, and ant trap development. Remarkably, the outcome showed that the fitness responses between the two trial runs, facilitated by the integration of MOALO, were strikingly similar, revealing a typical concaveconnected shape, which is characteristic of a multi-objective solver. The optimal multi-objective cost implication of the system was estimated to be around 4,300 USD, with a power mismatch performance of approximately -1.7819e+09. Based on these compelling findings, the study concluded that MOALO serves as an impressive optimization tool capable of minimizing power mismatches and optimizing costs. Moreover, it recommended the generation of excess power as a means to achieve sustainability.

Fxintegrity publishing

The use of plants/herbs as medicine for the care of diseases goes back to time immemorial, and still, plants are the dominant form of medicine in the world. Most of the world's population primarily depends on raw plant products to meet their health care needs. Several drugs include atropine, caffeine, digoxin, ephedrine, quinine, theophylline, tubocurarine, and warfarin. Taxol, vincristine and vinblastin are also derived from plants and used in modern systems of medicine. The authors in this book present comprehensive information about the history of medicinal plants from time immemorial to modern. Besides this, the traditional use and biological and phytochemical investigation of genera Phoenix, Castanospermum and Cordia are included in this book.

Dr. salman ahmed

Introduction: Schizotypal personality represents genetic underpinning of schizophrenia spectrum disorders; hence, it provides conceptual models for understanding psychosis as well as a scheme for high-risk group identification. The study of structure of schizotypal personality is largely confined to western societies, whereas its assessment in varied socio-cultural groups is highly required. Aim: To study the factor structure of schizotypal personality in an Indian population. Materials and Methods: A sample of 492 college students (age, Mean= 21.3, SD= 2.61) filled the Hindi translated version of 74- items Schizotypal Personality Questionnaire (SPQ). Confirmatory Factor Analysis (CFA) technique was used to test the fitness (consonance of the modeled relationships, among latent and observed variables, in the sampled population) of different schizotypal personality models, that is, two-, three-, four-, bi-, and uni-factor models. The best-fit model was also studied for Measurement Invariance (MI) across gender groups. Results: Three, four, and bi-factor models adequately fitted the data. Whereas, four-factor model was the best good-fit model. It also showed partially strong MI across gender groups. The internal consistency of total SPQ was 0.90 and of subscales ranged from 0.62 to 0.78. Men scored higher on several schizotypal facets but lower on social anxiety as compared to women. Conclusion: The factor structure of schizotypal personality in India is similar to that reported elsewhere in the world. Thus, the present study supports the generalisation of schizotypal personality construct to the Indian people.

Sanjay kumar

Lightweight materials are increasingly being used in engineering applications today. Composites are replacing traditional metallic materials in a variety of sectors, including aerospace, defence, and aircraft production, where there is a demand for structural materials with high strength-to-weight and stiffness-to-weight ratios. Natural fibre composites are also increasingly used in place of synthetic fibre composites in a variety of technical fields due to their affordability and environmental friendliness. In this particular study, Kevlar (Aramid fibres) is combined with other materials to improve the mechanical characteristics and impact resistance of composites. The only material that costs more than Kevlar is carbon fibres. The goal is to maximize mechanical qualities while utilizing the fewest amounts of pricey Kevlar fibres possible. The hand layup technique was used to create the hybrid composites, which included both natural and Aramid fibres. The performance of various mechanical properties was then assessed. In addition, a morphological examination was done to look at the interior structure of the composite materials that were examined. The results show that the hybrid composite, with or without the addition of nanoparticles, demonstrates great strength with little reliance on Kevlar fibres.

Boopathy govindarajan

The study aims to explore the possible morphological features of monosodium urate monohydrate crystals. The study was carried out on a glass slide under a microscope to observe the growth patterns. As a result, three types of spherical ring-banded, dumbbell, and composite spherulites were observed. This study gives detailed information about the morphology and aggregation patterns of mono sodium urate monohydrate crystals.

Dr. salman ahmed

Purpose: Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder mostly characterized by gonadotropins release and/or action deficiencies. Both isolated (idiopathic hypogonadotropic hypogonadism) and syndromic (Kallmann) forms are identified depending on the olfactory ability. Clinical and genetic heterogeneities of CHH have been widely explored, thus improving our understanding of the disease's pathophysiology. This work aims to (1) provide a detailed clinical and hormonal description of normosmic CHH patients and (2) identify the mutation linked to the studied phenotype. Participants and methods: We investigated three affected patients with normosmic CHH, belonging to a consanguineous Tunisian family. Patients underwent an insulin-induced hypoglycemia test. We performed whole exome sequencing to identify the causal mutation. Results: At first diagnosis, a total gonadotropic deficiency was identified in all patients. The insulin-induced hypoglycemia test has also revealed a reduced cortisol secretion and complete growth hormone deficiency. At 20.8 years, one female exhibited a spontaneous recovery of the hypothalamic-pituitary-adrenal axis function, unlike her affected siblings who still depend on corticosteroid replacement therapy. Herein, we identified a novel homozygous nonstop mutation (c.1195T>C) in KISS1R gene in all affected subjects. This mutation led to the substitution of the physiologic stop codon by an arginine (p.X399R). Conclusions: Our study highlights the importance of the KISS1R signaling, in gonadotropin-releasing hormone neurons, in the control of reproductive function. Additionally, our data suggests a complex central and peripheral metabolic control of puberty, through the hypothalamic KISS1R signaling. We suggest a mutual link between the hypothalamic-pituitary-gonadal, -adrenal, and -somatotropic axes.

Mariam moalla

This paper found that 35% of Adivasis have health problems, and 73% said that they are getting treatment with RMP. 87% have toilet facility and more than 12% still defecate openly. 18.3% said that they faced different problems at open defecation, and 50% of women not using sanitary napkins. Nearly 90% of respondents wash their hands after toilets and coming from outside of the home. Ten per cent of respondents said that they do not have an awareness of sanitation. Therefore, the study confirmed that the sanitation facilities considerably made the women's dignity and quality of life better in the study area. Moreover, four case studies also focused on open defecation problems in the study area.

B suresh lal

Urolithiasis is a common worldwide problem with high recurrence. This review covers forty four (44) families starting from alphabet A to L and includes Bignoniaceae (05); Araceae, Burseraceae, Combretaceae (04); Annonaceae, Berberidaceae, Betulaceae, Gentianaceae, Gesneriaceae (03); Aizoaceae, Adiantaceae, Alismataceae, Aristolochiaceae, Asclepiadaceae, Bombacaceae, Cannabaceae, Cyperaceae, Geraniaceae and Iridaceae (02); Acoraceae, Adoxaceae, Armatellaceae, Aquifoliaceae, Araliaceae, Averrhoeaceae, Basellaceae, Begoniaceae, Bromeliaceae, Cactaceae, Calophyllaceae, Campanulaceae, Caprifoliaceae, Caricaceae, Celastraceae, Clusiaceae, Dracaenaceae, Dryopteridaceae, Elaeagnaceae, Grossulariaceae, Hyacinthaceae, Hydrangeaceae, Hypoxidaceae, llecebraceae and Juglandaceae (01) plant used globally in different countries. The plants of three families Asteraceae, Fabaceae and Lamiaceae are revisited to provide updated information. This review will not only be useful for the general public but also attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Background: In a Benghazi medical center, this observational study assessed the role of laparoscopic cholecystectomy (LC) in the early stages of acute gallbladder illness. Materials and Methods: From January 2022 to December 2022, all emergency and urgent admissions for acute gallbladder disease were identified, and additionally, data from hospital medical records were then evaluated retrospectively. Results: Out of a total of 334 patients with gallstone diseases, we found 321 individuals (206 with acute biliary colic, 115 with acute calculous cholecystitis), and 13 with acalculous cholecystitis. Early laparoscopic surgery for acute calculous cholecystitis had a greater conversion rate than procedures for acute biliary discomfort (19% vs. 4%; p=0.002). When surgery was performed 72 h from the onset of the symptoms for patients with acute calculous cholecystitis, the conversion rate was considerably lower (one out of 25) than when surgery was postponed past 72 h (14 out of 53) or later performed electively (seven out of 23) (p=0.014). In comparison to elective surgery for acute biliary colic (three of 66), elective surgery for prior acute cholecystitis was linked to a higher conversion rate (seven of 22 patients) (p=0.002). Conclusion: LC for acute calculous cholecystitis needs to be done within 72 h of the onset of symptoms, and it is worthwhile.

Karishma

Noncommunicable diseases, also known as chronic diseases, tend to last long and result from genetic, physiological, environmental, and behavioural factors. Uric acid nephrolithiasis, arthritis and gout come under noncommunicable diseases related with Monosodium urate monohydrate (MSUM ) crystals. MSUM crystals are deposited in peripheral joints, causing gout and eliciting an intense localized inflammatory attack. In contrast, in collecting ducts and medullary interstitium, it is a urinary calculi which causes dysuria, nausea and hematuria. The study aims to explore the possible morphological features of monosodium urate monohydrate crystals. The study was carried out on a glass slide under a microscope to observe the growth patterns of MSUM crystals. For this purpose, a drop of gel medium (sodium meta silicate solution + 0.2M sodium hydroxide + 2N acetic acid) at pH 5.02 - 5.17 was placed in the middle of a glass slide and converted into a gel. A 0.07 M uric acid drop was added to the adequately formed gel. The glass slide was observed under a microscope till it was completely dried. Monosodium urate monohydrate was formed as spherical ring banded spherulites, dumbbell and composite spherulites. The current study provides different phases of MSUM crystallization on a glass slide for the first time. It may also be used as a model to evaluate prophylactic management against gouty and renal stones through in vitro assessment of crystal growth and aggregation inhibition and modulation of developing or developed crystals by using different natural products.

Dr. salman ahmed

Learning is a conscious effort made by individuals to acquire various kinds of abilities (competencies), skills (skills), and attitudes (attitudes) through a series of learning processes that will ultimately result in behavioral changes in the individual. The learning process in schools tends to emphasize the achievement of changes in cognitive (intellectual) aspects which are carried out through various forms of approaches, strategies, and certain learning models. Learning systems that specifically develop affective abilities have received less attention, affective abilities are only used as a nurturing effect. This study aims to (1) find out whether online learning is able to bring out the affective abilities of prospective study program teachers (2) analyze the affective abilities of prospective teachers in online learning. The data used in this study is qualitative data. The technique used is a questionnaire. This questionnaire was given to respondents, namely students of PGSD teacher candidates at Muhammadiyah University of Pringsewu. The results of the study indicate that affective abilities can appear in online learning as evidenced by the results of the questionnaire that has been given to respondents. The indicators of affective ability in this study include attitudes, interests, self-concept, values, and morals, all of which are in the good range. This means that the results of students' affective abilities can be said to be valid or appear in online learning

Educare: journal of primary education

Abstract: Recent studies on hydrogels have shown them as promising biomaterials for numerous applications involving tissue engineering, drug-screening, drug-delivery, and 3-D bioprinting because they show unique physicochemical properties. The ability of these structures to hold large amounts of water is because of their hydrophilic nature that provides a soft and hydrated environment like natural tissues. This makes them ideal for mimicking the extracellular matrix and supporting cell growth and proliferation. In tissue engineering, hydrogels might be used to create scaffolds that promote cell growth and facilitate tissue regeneration. Hydrogels can also be engineered in such a way that they intimate the mechanical and biochemical in vivo characteristics making them a versatile tool for applications in tissue engineering. Hydrogels are being used in drug screening, as they can be functionalized with different biochemicals in order to match the microenvironment of specific tissues. This allows researchers to study how drugs interact with cells and tissues in-vitro conditions, which can lead to more efficient strategies for drug development. For applications in drug delivery hydrogels are designed to release drugs in a sustainable and controlled way, improving the drug efficacy and reducing the toxicity of drugs. Designing can also be done in a way that they can target specific tissues and cells making them a promising tool for personalized medicine. Hydrogels are being used in 3-D bioprinting, where they serve as bio-inks that can be fabricated into complex structures with high precision. In comparison to conventional technologies, this is a promising technique that allows the construction of complex three-dimensional structures in a sequential manner by a computeraided system. One major challenge in bioprinting is finding such material that is suitable for printing and also satisfies the mechanical strength requisite for tissue engineering applications. That is where hydrogels serve as the most appropriate model and have encouraging or favorable operation potential as cell-affable materials. This technique has revolutionized tissue engineering by allowing researchers to create functional tissues and organoids and spheroids. Overall, hydrogel-based tissue engineering, drug screening, drug delivery, and 3D bioprinting are exciting areas of research with great potential to significantly impact different areas of medicine and biology.

Deepika pal

Shell and tube heat exchanger is the most common type of heat exchanger, widely used in oil refinery and other large chemical process. The energy present in the exit stream of many energy conversion devices such as I. C engines, Gas turbines etc. goes as waste, if not utilized properly. For example, the heat energy stored in the engine coolant can be utilized in a better way by recovering the heat for heating purposes inside the cabin. It is comparatively economical than the existing heating arrangements, which employ conventional heating coils. So, the present work has been carried out with a view to predicting the performance of a shell and tube heat exchanger in the field of waste heat recovery application. The objective of this project is to design a shell and tube heat exchanger and study the flow and temperature field inside the shell and tubes using ANSYS Fluent R14.5. An attempt has been made to calculate the performance of the above heat exchanger with and without baffles for parallel flow configurations, and the results so obtained have been compared.

Boopathy govindarajan

The blunted nose cone with and without a sharp aerospike and an aerodisk of various diameters and lengths are investigated numerically in detail in the current study at a hypersonic Mach number of 10. The aerodisk diameter is described as d/D ratios such as 0.2, 0.4 and 0.6, and the length of the aerospike is represented as the L/D ratio of 1, 1.5 and 2. The main objective of the research is to examine the aerodynamic properties of blunt noses with and without aerodisks and aerospikes, as well as the influence of shock production over the model. The design of blunted nose cones with aerodisk was made up using CATIA and numerical investigation was performed on the ANSYS Fluent. The turbulence model of SST k-omega was considered for study. The current study revealed that shock patterns drastically varied nearer to the nose cone model at L/D ratio 2 and variation of drag reduction occurred due to the increase in d/D ratio and aerospike and also flow pattern over the model was clearly investigated.

Boopathy govindarajan

Garcinia cambogia, commonly known as Asam Gelugur, has entrenched itself as a traditional herbal medicine, renowned for its applications in treating obesity and its integration into global nutraceutical formulations. The bioactive compounds within, particularly hydroxy citric acid, mediate various effects. This study aims to assess the in vitro cytotoxicity of Taxol, a cytotoxic drug used as a control, and the aqueous extract from Garcinia cambogia against the Vero cell line - a kidney-like cell. Cytotoxicity was evaluated using the 3-(4,5-dimetyl-2-2thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The assay relies on mitochondrial succinate dehydrogenase's potential to reduce MTT, providing a colorimetric indication of cell viability. The results revealed an IC50 value exceeding 500 µg/mL for the aqueous extract from Garcinia cambogia significantly higher than Taxol's 0.0581 µg/mL. This higher IC50 value implies lower toxicity, positioning the Garcinia cambogia extract as a safe component in nutraceuticals and herbal supplements. The aqueous extract of Garcinia cambogia demonstrates low cytotoxicity, reinforcing its safety profile for use in nutraceuticals, which contributes valuable insights into the safety considerations of incorporating Garcinia cambogia into herbal supplements.

Mediterranean journal of pharmacy and pharmaceutical sciences

The COVID-19 crisis has impacted all dimensions of our lives say it as the public health, the labour system, the social interaction, the political debate, the use of public spaces, the economy, the environment, and last but not the least it has proved to be a major contributor to the cultural value system of the individual living in society. This research paper is to analyse and understand the changes enforced by this pandemic on Indian culture and individual of the society. It also analyses the context of COVID-19 scenario with special reference to Indian culture and Hofstede’s theory of cultural dimension. This research paper is an attempt to emphasize the changes in culture and value system during the COVID-19 pandemic faced by India. India is enriched enough in cultural dimensions to combat COVID-19. The Hofstede’s model analysed in depth also leads to this finding that it also fits well in the present context. Thus, it is hereby summed up that as India is enriched in its cultural values it has posed itself as a fighter for this pandemic

Mamta gaur

This study aims to examine and compare the levels and patterns of aggressive behavior among higher secondary students in rural, semi-urban, and urban areas. Aggression among adolescents is a significant concern, and understanding its variations across different settings can provide valuable insights for intervention and prevention strategies. The study employs a review-based research design, using articles published between 1993 and 2023 to collect data on aggressive behavior of higher secondary students. For this purpose, a review of the literature was performed by using the search words “aggressive behavior”, “higher secondary students”, “rural”, “semi-urban”, “urban” in the databases like Google Scholar, ResearchGate, Academia, Shodhganga, PubMed, JSTOR and Elsevier for articles. The results will shed light on the prevalence, types, and potential factors influencing aggression in these areas, informing the development of targeted interventions and policy recommendations and statistical analyses will be employed to examine the relationships between variables. Importance and Scope of the Topic: Aggressive behavior is a topic that affects us all. From playground bullies to road rage enthusiasts, aggressive behavior has a significant impact on our daily lives. Understanding the causes and consequences of aggression is crucial in finding ways to prevent and manage such behavior. After all, the world would be a much better place if we all knew how to calm down and express our frustrations in healthy ways.

Abdul jaleel kuzhiyengal mambra

Most of mosquito-repellent products and devices are made up of synthetic materials presenting market which causes various harmful effects on human beings. The resistance can be developed by the mosquito due to continuous exposure at high doses. Hence, the present research work represents the development and evaluation of mosquito repellent sticks with the help of various herbal products such as starch powder, wood powder, charcoal powder, eucalyptus oil, coconut oil, lavender oil, lemongrass and cinnamon oil, peppermint and citronella, neem oil making them ozone-friendly, financial effective, non-harmful.

Archana mehrotra

Financial sector needs special attention pertaining to incorporation of the ESG criteria. Economic and financial issues coupled with climate change would have negative impact on the stability of financial institutions. This research paper attempts to synthesize and summarise scholarly articles published in Scopus database on ESG domain with reference to banking sector using bibliometric analysis. The objective of this review paper is to understand from past literature the trajectory of studies in the domain of ESG. There is a substantial growth in frequency of publication in the year 2022 along with annual growth of around 30 percent during 2015-2023. Bibliometric with MS-Excel, R-Studio and VOS-viewer were used to identify and analyze research trends related to the number of studies, research fields, authors, nations, institutions, and keywords. The important keywords identified in the bibliometric analysis were sustainability, corporate social responsibility, sustainable finance, banks performance.

Dr. mohammed nizamuddin