Postpartum depression is a major maternal health problem after childbirth. It can start at any time within the first year after delivery and continue for several years. It is characterized by an inability to experience pleasure, anxiety symptoms, panic attacks, spontaneous crying and depressed mood. Some women with postpartum depression even have thoughts of harming their child and self-harm. The aim of this study is to find out the status of postpartum depression and the associated factors among postnatal mothers at first-, fourth- and sixth-month. This study is a prospective descriptive study, carried out in three major health facilities in Misurata. This study consists of three-part questionnaire. Part 1 covers demographic characteristics of the participants, while part 2 explores the associated risk factors according to the variables used. Part 3 constitutes for the psychological evaluation of the participants. Hundred mothers (age are between 15 and 43 years) were enrolled in this study. The findings revealed that prevalence of depression is 60% and 22% are suffering from borderline depression. Development of depression was strongly correlated with the sleeping disturbances, state of the neonate after birth, excess consumption of stimulants, less weight acceptance by mothers during pregnancy and infant illness. There was a weak relation between depression and delivery state, maternal admission to hospital during current pregnancy, and infant gender dissatisfaction. No correlation was found with development of depression regarding miscarriage, maternal medical problems after delivery, previous child sex, maternal age, education, parity or neonate weight. Thus, this study shows that a chance of having miscarriage and unhealthy neonate increases with advanced maternal age. It also shows that caesarean section is associated with bad neonatal outcomes, more weight gain and having gestational diabetes or preeclampsia during pregnancy. Maternal sleeping problems are more pronounced in the first month, attributing for the baby care, compared with fourth and sixth months. The study indicates that depression is a common state of psychiatric disorders among Libyan women and should have an appropriate attention by physicians and gynecologists.

Mediterranean journal of pharmacy and pharmaceutical sciences

Recent reports showed an association between bariatric surgery and the development of acute pancreatitis. This report presents a case of acute pancreatitis following a laparoscopic sleeve gastrectomy (LSG) in a 24-year-old Indian female patient, who presented to the Emergency Department at Hamad General Hospital, Qatar, with severe epigastric pain and persistent vomiting 13 days after LSG. She was diagnosed with acute pancreatitis based on a high level of lipase greater than three times the upper limit of normal, and a computed tomography scan of the abdomen, which was consistent with acute pancreatitis. The patient was treated conservatively with a significant improvement in her symptoms and laboratory tests throughout her admission and consequently was discharged.

Karishma

This chapter discusses the effects of stimuli that combine sexuality and aggression. It outlines the debate over aggressive versus nonaggressive pornography and discusses the frequency of aggressive pornography and bases for concern. Aggressive pornography and sexual arousal is explored in the chapter wherein initial findings, victim's responses, individual differences, context of assessment, and conclusions are discussed. The chapter reviews the effects of aggressive pornography on responses other than aggression wherein it has discussed about changes in sexual responsiveness, fantasies, and perceptions and attitudes. The effects of aggressive pornography on aggression are explored in the chapter wherein research findings are discussed in detail and summary of effects on aggression, theoretical analyses, and the construct validity of assessing aggression are also described. The data across the laboratory and field experiments discussed in this chapter raise a variety of theoretical and empirical issues that should be addressed in future research. Particularly noteworthy are questions concerning stimuli, subject, and setting characteristics.

John dolores

Corona virus pandemic has swept a major section of the world population. In terms of infectivity it�s higher than any pandemic in the recent past. Corona virus, a member of the family Coronaviridae, spread from bat to human through an intermediate host pangolin. It has lower mortality rate than the previous pandemics in last 100 years such as Spanish Flu(1918-20),Asian Flu (1957-58), SARS Corona virus (SARS-Cov) (2003), H1N1 Swine Flu Pandemic(2009-10), Middle East Respiratory Syndrome (MERS) (2012), West African Ebola (2014-16) etc. Research shows Covid spike attaches ACE2 receptor; it leads to a release of cytokine into the blood capillaries near the alveoli and may ultimately turn into pneumonia. The alveoli get collapsed leading ARDF. The pulmonary inflammation proceeds to systemic inflammation that causes multiple organ failure. Drug like Chloroquine, Lopinavir/ritonavir, and Remdesivir may halt the spread of the virus in the body. Antipyretic is prescribed to reduce the temperature. This article comprises of detail mechanism of the dreadful disease along with its diagnosis and proposed treatment. This exploratory study mainly designed to generate awareness and provide information to the individuals who want to know the A to Z of Covid in nutshell. This article may create a pathway to number of upcoming scientific researches and may attract them to work on this field to enhance the probability of inventing appropriate vaccine and medicine to fight against this contagious disease and to win the battle against this Global Pandemic.

Dipa mitra

Obesity is a complex and challenging global public health concern. It is a major disease involving excessive fat accumulation that may impair health. Obesity is dangerous and has been related to a range of long-term health issues that can impact adults and children. According to the World Health Organization, more than one billion people worldwide are obese as of March 2022. In the Libyan situation, the prevalence of obesity has increased among the public over the last decade. This cross-sectional survey-based study is conducted by using self-structured designed questionnaire to evaluate the use of anti-obesity drugs and herbal products among Libyan people. Additionally, considered as an indirect method, pharmacist performance in obesity management was also evaluated. The investigators collected interview data from three different cities in the Northwest of Libya over a period of five months, 2019. A total of 170 participants who use weight loss products were randomly selected to participate in the study after obtaining their verbal consent. The participants' experience with weight reduction agents revealed that more than half of the participants (52.3%) used herbal products while 32.0% of the participants have used drugs of chemical origin and 15.6% have used both (herbal and drugs). The majority of the participants (91.4%) used these products without medical consultation which in turn led to failure to lose and maintain weight with 74.2% gaining weight after stopping using these products. In conclusion, poor pharmacist intervention in obesity management was revealed where the majority of the participants reported that Libyan community pharmacists had not been offering weight management services, monitoring weight loss progress, or explaining the risks of being overweight or obese.

Mediterranean journal of pharmacy and pharmaceutical sciences

Brain tumors (BTs) are deadly diseases that can strike people of every age, all over the world. Every year, thousands of people die of brain tumors. Brain-related diagnoses require caution, and even the smallest error in diagnosis can have negative repercussions. Medical errors in brain tumor diagnosis are common and frequently result in higher patient mortality rates. Magnetic resonance imaging (MRI) is widely used for tumor evaluation and detection. However, MRI generates large amounts of data, making manual segmentation difficult and laborious work, limiting the use of accurate measurements in clinical practice. As a result, automated and dependable segmentation methods are required. Automatic segmentation and early detection of brain tumors are difficult tasks in computer vision due to their high spatial and structural variability. Therefore, early diagnosis or detection and treatment are critical. Various traditional Machine learning (ML) techniques have been used to detect various types of brain tumors. The main issue with these models is that the features were manually extracted. To address the aforementioned insightful issues, this paper presents a hybrid deep transfer learning (GN-AlexNet) model of BT tri-classification (pituitary, meningioma, and glioma). The proposed model combines GoogleNet architecture with the AlexNet model by removing the five layers of GoogleNet and adding ten layers of the AlexNet model, which extracts features and classifies them automatically. On the same CE-MRI dataset, the proposed model was compared to transfer learning techniques (VGG-16, AlexNet, SqeezNet, ResNet, and MobileNet-V2) and ML/DL. The proposed model outperformed the current methods in terms of accuracy and sensitivity (accuracy of 99.51% and sensitivity of 98.90%).

Mehdhar s. a. m. al-gaashani

The analgesic activity Of the crude hexane and ethanol extracts of the leaves and male flowers of Luffa cylindrica (L.) Roem., (sponge gourds) was carried out at dose of 500 mg /kg b.w., (p.o.) in mechanically induced pain in rats by using analgesy-meter. These extracts produced significant analgesic effect results of the present study revealed the analgesic properties of the leaves and male flowers of Luffa cylindrica.

Dr. salman ahmed

Study objectives: The study aimed to evaluate the antitussive effect of aerial parts of ethanolic extract of Caesalpinia pulcherrima (Caesalpiniaceae). Methods: In this study, cough was induced by the sulfur dioxide induction method. Four groups of animals were made, with six animals in each group, and all drugs were administered orally. Group I was used as a control, group II as a standard, and groups III and IV received 200 and 400 mg/kg Caesalpinia pulcherrima aerial parts extract. Results: Caesalpinia pulcherrima aerial parts (CPAP) extract suppressed cough. Doses of 200 and 400 mg/kg Caesalpinia pulcherrima aerial parts extract showed highly significant results compared to the standard at 60 and 90 min of drug administration. Conclusion: From the above results, it can be concluded that plants have significant activity in cough suppression.

Dr. salman ahmed

Pharmacists are expected to play major roles as members of diverse perioperative care teams besides implementing medication safety standards, pharmacist’s roles include optimizing drug therapy and other clinical interventions. Yet, developing general perioperative management as another crucial role operation room, pharmacists play and incorporating it into pharmaceutical education would be important. Enriching perioperative care provided by pharmacists can contribute toward improving the clinical competence of these professionals. Presently, there are no pharmacists in Zawia who participate in perioperative care. The objective of this study was to assess the pharmacist's knowledge of general anesthesia and drugs used to anesthetize patients who suffer from hypertension. A cross-sectional study was conducted in Zawia City, Tripoli in 2023. A self-designed questionnaire was distributed to 100 pharmacists. The study found that more than half of the pharmacists have humble knowledge about the drugs used in anesthesia, the findings indicated weakness in their information about drugs used to manage hypertension in surgery, and 36.0% know that sodium nitroprusside is used to control blood pressure during the operation. In conclusion, this study reported that some of the study's pharmacist participants had weak points that contributed to a high percentage of incorrect knowledge. These weak points may be attributable to poor educational preparation or a lack of training before the pharmacists began working in hospitals.

Mediterranean journal of pharmacy and pharmaceutical sciences

The aim of this study was to evaluate the proximate and micronutrient composition, physical, biochemical and sensory properties of the bread produced from blends of wheat, acha, uzaaku and unere composite flours. Six samples (A-F) were produced in the following ratios A= 100:0:0 (100% Wheat), B= 80% wheat flour, 10% acha, 5% uzaaku flour, 5% unere; C = 70% wheat flour, 10% acha, 10% uzaaku flour, 10% unere; D = 60% wheat flour, 15% acha, 15% uzaaku flour, 10% unere; E = 50% wheat flour, 20% acha, 15% uzaaku flour, 15% unere; F = 40% wheat flour, 20% acha, 20% uzaaku flour, 20% unere. The parameters were analyzed using standard methods. The proximate composition of the bread showed significant increase (p<0.05) in protein, fat, crude fibre, ash, and caloric (energy) value which ranged between 7.69-18.32%, 2.41-3.70%, 2.473.86%, 3.09-4.03%, and 285.25-304.06 (Kcal/kg) and a significant decrease (p<0.05) in moisture content (20.72-26.14%) and carbohydrate (49.37-58.20%), respectively. The micronutrient content showed increase in calcium, magnesium, potassium, iron, zinc, phosphorus, vitamin B1, B2, B3, A and C as the amount of substituted flour blends increases. The result of the physical properties showed decrease in the loaf weight, loaf height, loaf volume and specific volume ranged from 240.60-218.80 g, 3.33-6.66 cm, 155.00-205.00 cm3, 0.71-0.85 cm3/g, respectively. The result of the serum biochemical parameters of rats fed the composite bread samples showed significant decrease (p<0.05) in AST, ALT, ALP, Bilirubin, creatine, urea and albumin values, respectively. The sensory attributes of the bread showed significant differences (p<0.05) in colour, aroma, taste, crumb texture and general acceptability such that the values obtained ranged from 6.05-8.90, 6.008.45, 6.40-8.60, 5.85-8.30 and 6.10-8.35, respectively. The findings of the study showed that supplementation of wheat with 10% acha, 10% uzaaku and 10% unere flour blends could produce well accepted bread samples.

Okechukwu obed chukwuemeka

Vaccination hesitation may affect the national efforts to slow down the spread of coronavirus among the population. This study was aimed to explore the views of final year pharmacy students at Faculty of Pharmacy, Elmergib University, Al kums, Libya towards COVID-19 vaccination. The study was conducted before the vaccine becomes available in Libya. A semi-structured questionnaire was distributed on March 14, 2021 to the fourth- year pharmacy students at Elmergib ‎University, Al khums Libya. Results showed a high degree of hesitancy towards vaccination against this virus (52.6%). Student's participants who said they would take the vaccine probably have said that because of their stress that caused by COVID-19 pandemic (47.4%). With regard to the gender, the participants’ views had no significant difference between male and female students on whether to take the vaccine or not (P = 0.825). In conclusion, hesitations towards vaccination and stress caused by student fear from the virus need to be addressed to minimize public reluctant to take the vaccine and to improve the education process during the pandemic.

Mediterranean journal of pharmacy and pharmaceutical sciences

In the teaching and learning process, teachers are required to be able to carry out their role to the fullest as a motivator and initiator in an effort to maintain and at the same time increase the enthusiasm of students to learn. Especially in the Covid-19 pandemic situation which requires educational institutions to carry out online learning. This study aims to discuss the teacher's role as a motivator and the teacher's role as an initiator in improving the quality of student learning in online learning at Madrasah Ibtidaiyah Ma'arif Condro Jember. This research uses qualitative research methods and the type of research is a case study. Data collection techniques using observation, interviews and documentation. The validity of the data using source triangulation and technical triangulation. Meanwhile, data analysis uses data condensation, data presentation and verification/conclusion. The results of this study indicate: 1) The teacher's role as a motivator in improving the quality of learning in online learning, namely: providing opportunities for students to play an active role in learning, providing reinforcement, praise or verbal appreciation, teachers listening to students' concerns and wishes to bond. good relationship between teachers and students. 2) The role of the teacher as an initiator in improving the quality of learning in online learning, namely: utilizing information and communication technology such as Whatsapp, Facebook, Google Meet and Google Form. Dalam proses belajar mengajar, guru dituntut untuk mampu melaksanakan perannya secara maksimal menjadi motivator dan inisiator dalam upaya menjaga dan sekaligus meningkatkan semangat belajar peserta didik. Terlebih dalam situasi pandemi Covid-19 yang menuntut lembaga pendidikan untuk melaksanakan pembelajaran secara Daring. Penelitian ini bertujuan untuk membahas tentang peran guru sebagai motivator dan peran guru sebagai inisiator dalam meningkatan kualitas belajar peserta didik pada pembelajaran daring di Madrasah Ibtidaiyah Ma’arif Condro Jember. Penelitian ini menggunakan metode penelitian kualitatif dan jenis penelitiannya adalah studi kasus. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Keabsahan data menggunakan triangulasi sumber dan triangulasi teknik. Sedangkan analisis data menggunakan kondensasi data, penyajian data dan verifikasi/kesimpulan. Hasil penelitian ini menunjukkan: 1) Peran guru sebagai motivator dalam meningkatkan kualitas belajar pada pembelajaran daring yaitu: memberikan kesempatan kepada peserta didik untuk berperan aktif dalam pembelajaran, memberikan penguatan, pujian atau apresiasi secara verbal, guru mendengarkan keresahan dan keinginan peserta didik agar terjalin ikatan yang baik antara guru dan peserta didik. 2) Peran guru sebagai inisiator dalam meningkatkan kualitas belajar pada pembelajaran daring yaitu: memanfaatkan teknologi informasi dan komunikasi seperti Whatsapp, Facebook, Google Meet dan Google Form.

Educare: journal of primary education

This research work aimed to evaluate the effects of thermal processing treatments on the nutrient anti-nutrient composition of Afzelia africana (Akparata) flour. The seeds were sorted, cleaned and processed into boiled, roasted and autoclaved lima bean flours. The flours obtained were analysed for proximate, vitamin and anti-nutrient contents using standard methods. The proximate composition of the samples revealed that the flours had a range of moisture, 8.23-12.40%, crude protein, 15.98-25.95%, fat, 21.00-28.21%, ash, 1.34-2.89%, crude fibre, 2.00-3.45%, carbohydrate, 38.68-49.33%, and energy 424.13 – 482.37kJ/100g, respectively. The vitamin contents of the flours showed that the samples contained 0.02±0.00 - 0.08±0.00mg/100g riboflavin, 0.78 - 1.98 mg/100g niacin, 0.40 - 0.89 mg/100g thiamine, 120.40-234.70mg/100g vitamin A, 72.11-134.19mg/100g ascorbic acid, 09.67-17.65mg/100g vitamin E, 310.60-430.60mg/100g B6, 3.47-5.87mg/100g B12, respectively. The result of the anti-nutrient composition of the flours also showed that the phytate, tannin, oxalate, cyanogenic glycosides, protease inhibitors, haemagglutinins inhibitors, levels of the samples were significantly (p<0.05) reduced by roasting and boiling treatments compared to the sample processed by autoclaving. In addition, the saponin content of the flours was relatively higher in boiled sample than in roasted and autoclaved flours. However, the nutrient and anti-nutrient contents of the flours observed that the flours have the potentials to be used as nutritional supplements in the preparation of a variety of food products than the raw sample.

Okechukwu obed chukwuemeka

The seed flours of Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn., and Phaseolus vulgaris Linn. were investigated for their total, soluble and insoluble oxalate contents by HPLC. The total oxalate content of Macrotyloma uniflorum, Phaseolus lunatus and Phaseolus vulgaris were 1.24, 1.77 and 1.71 mg/ g, respectively. The % age of soluble oxalate was Macrotyloma uniflorum (19.50), Phaseolus lunatus (15.08) and Phaseolus vulgaris (15.88). The calculated soluble oxalate: calcium ratio of all tested legume flours is lesser than one and hence will not create any resistance in calcium bioavailability.

Dr. salman ahmed

Aminopyrine (AM) has been used as a model substrate for investigation of drug metabolism. The major metabolic route is N-demethylation that was confirmed in liver microsomes. The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating the N-demethylation of 4-di-methylaminoantipyrine (4-DMAA) to 4-methylaminoantipyrine (4-MAA). The contribution of human CYP to the metabolism of (4-DMAA) to (4-MAA) in human was investigated using virus expressed human CYP, human liver microsomes with chemical inhibition studies. The substrate of 4-dimethylaminantipyrine was employed at different concentrations (11.5, 23, 46, 115 and 230 µmol per l) with varying concentrations of selective inhibitors of CYP (CYP1A2), (CYP3A4), (CYP2C8),(CYP2A6), (CYP2D6), (CYP2C19) and (CYP1A1). 4-DMAA and 4-MAA were analysed by HPLC and enzyme kinetic parameters (Km and Vmax) were calculated from the concentration data. The transformation of 4-dimethylaminoantipyrine to 4-methyaminoantipyrine by microsomes prepared from baculovirus-expressed human CYP was pronounced with CYP2D6. The metabolism of 4-dimethylaminoantipyrine was inhibited by 60.0% and 55.17% by a concentration of 100 µmo per l of the known CYP2D6 inhibitors quinidine and moclobemide. The corresponding Ki values were 0.050 and 0.11 mM, respectively. The corresponding IC50 values were 0.06 and 0.13 mM, respectively. The enzyme CYP2D6 apparently has an important role in N-demethyl-ation of 4-dimethylaminoantipyrine.

Mediterranean journal of pharmacy and pharmaceutical sciences

There is a close relationship between a marketing strategy and its ability to realise its mission, vision, and business strategy. A case in point is the Nike brand that focuses on creating meaningful stories for its loyal fan base. It achieves this by inducing emotions into the customer base through "emotional branding" to realise its vision of expanding human potential by creating groundbreaking sports innovations. Nike's marketing campaign strategy involves building meaningful stories and tag lines using a traditional narrative of a hero who overcomes every challenge brought forth through its slogan of "Just Do It." The brand also has a distribution strategy of using subsidiaries like Converse, Jordan, and Hurley and channels like retailers, e-commerce, and supermarkets to reach out to millions of its customers (Mahdi, Abbas, Mazar, & George, 2015). To achieve its mission of bringing innovation and inspiration to every athlete globally, the brand has invested in top-notch technologies like hyper-adapt as part of a marketing strategy.

Zamzam abdelazim

The paper reports the results collected from social work students (SW) and nonsocial work students (NSW) of Ho Chi Minh City Open University (OU) through attitudes toward poverty and poor people in Vietnam. The Attitude toward Poverty Short Form (ATP-SF) 21-item (ATP-SF) scale, developed by Yun & Weaver (2010), was used for the data collection. The sample of this study comprises 180 students enrolled in three disciplines: social work (n = 86), law (n = 34), foreign language (n = 30) and economics (n = 30). The questionnaire was used to collect the data for the study. Cronbach’s alpha and independent t-tests were run to compare means between two groups of students. All students voluntarily participated in the survey.

Le minh tien

X-ray crystallography has been central to the development of many fields of science over the past century. It has now matured to a point that as long as good-quality crystals are available, their atomic structure can be routinely determined in three dimensions. However, many samples in physics, chemistry, materials science, nanoscience, geology, and biology are noncrystalline, and thus their three-dimensional structures are not accessible by traditional x-ray crystallography. Overcoming this hurdle has required the development of new coherent imaging methods to harness new coherent x-ray light sources. Here we review the revolutionary advances that are transforming x-ray sources and imaging in the 21st century.

Nima fahimian, md

Pneumocephalus is a rare condition characterized by the presence of intracranial air, most commonly seen after head trauma or surgery. Although it is often asymptomatic, it can lead to serious complications such as tension pneumocephalus and seizures. This study presents a case of iatrogenic pneumocephalus and seizures that developed after a flap rotation operation in a patient with a history of craniotomy. An 82-year-old male patient presented to the emergency department shortly after flap rotation surgery with loss of consciousness and generalized tonicclonic seizures. Brain computed tomography revealed a left temporal bone defect and epidural air collection. Diffusion magnetic resonance imaging showed no acute ischemic lesion. The patient was initially started on levetiracetam, but due to side effects, he was switched to a combination of valproate and lamotrigine. The patient developed pneumonia during follow-up and was treated in the intensive care unit and discharged in stable condition. In patients who have previously undergone craniotomy, the risk of pneumocephalus should be considered even in minor surgical procedures, and early imaging should be performed when new neurological symptoms develop.

Karishma

Purpose: Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder mostly characterized by gonadotropins release and/or action deficiencies. Both isolated (idiopathic hypogonadotropic hypogonadism) and syndromic (Kallmann) forms are identified depending on the olfactory ability. Clinical and genetic heterogeneities of CHH have been widely explored, thus improving our understanding of the disease's pathophysiology. This work aims to (1) provide a detailed clinical and hormonal description of normosmic CHH patients and (2) identify the mutation linked to the studied phenotype. Participants and methods: We investigated three affected patients with normosmic CHH, belonging to a consanguineous Tunisian family. Patients underwent an insulin-induced hypoglycemia test. We performed whole exome sequencing to identify the causal mutation. Results: At first diagnosis, a total gonadotropic deficiency was identified in all patients. The insulin-induced hypoglycemia test has also revealed a reduced cortisol secretion and complete growth hormone deficiency. At 20.8 years, one female exhibited a spontaneous recovery of the hypothalamic-pituitary-adrenal axis function, unlike her affected siblings who still depend on corticosteroid replacement therapy. Herein, we identified a novel homozygous nonstop mutation (c.1195T>C) in KISS1R gene in all affected subjects. This mutation led to the substitution of the physiologic stop codon by an arginine (p.X399R). Conclusions: Our study highlights the importance of the KISS1R signaling, in gonadotropin-releasing hormone neurons, in the control of reproductive function. Additionally, our data suggests a complex central and peripheral metabolic control of puberty, through the hypothalamic KISS1R signaling. We suggest a mutual link between the hypothalamic-pituitary-gonadal, -adrenal, and -somatotropic axes.

Mariam moalla