Emesis is defined as a forceful expulsion of stomach contents via the mouth. The adverse effects of available anti-emetic drugs potentiate us to evaluate natural products to explore effective natural anti-emetics with fewer side effects. The fruits of Illicium verum Hook. f. were selected for anti-emetic activity based on their folkloric use against gastrointestinal complaints. Crude methanolic extract and its aqueous, dichloromethane, ethylacetate and hexane fractions were evaluated using the copper sulphate-induced chick emesis model. Emesis was induced by the oral administration of copper sulfate 10 ml/kg body weight and metoclopramide (150 mg/kg p.o.) as a standard anti-emetic drug. The anti-emetic effect was observed by calculating the mean decrease in the number of retches compared to that of the control. Methanolic extract and its fractions were tested at 25, 50 and 75 mg/kg oral doses. Among all tested fractions, ethyl acetate showed the highest (94.46%), and hexane showed the lowest (56.30%) anti-emetic activity at 50 mg/kg. Further, isolation and purification from the same fractions are in process to discover effective natural anti-emetic compound(s) with less unwanted effects.

Dr. salman ahmed

Background: While osteoporosis increases the risk of fragility fractures, bisphosphonate has been proven to increase bone strengthand reduce the risk of vertebral and non-vertebral fractures. In addition to its efficacy, substituting the brand with generic medication isa strategy to optimize healthcare expenditures. This study aimed to evaluate the efficacy of generic alendronate treatment and assesspotential adverse events in patients with osteoporosis.Materials and Methods: A retrospective review was conducted on 120 patients who met the indications for osteoporosis treatment,received weekly generic alendronate (70 mg) for >1 year, and underwent evaluation through standard axial dual-energy X-rayabsorptiometry (DXA). The outcomes of this study were the percent change in bone mineral density (BMD) at the lumbar spine,femoral neck, and total hip after one year of treatment. The major adverse events occurring during medication that led to thediscontinuation of drug administration were documented.Results: Most patients were female (96.7%) with an average age of 69.0 ± 9.3 years. The percent change in BMD increased at all sitesafter one year of generic alendronate treatment (lumbar spine: 5.6 ± 13.7, p-value <0.001; femoral neck: 2.3 ± 8.3, p-value = 0.023;total hip: 2.1 ± 6.2, p-value = 0.003), with over 85% of patients experiencing increased or stable BMD. Three patients discontinued themedication due to adverse effects: two had dyspepsia, and one had persistent myalgia.Conclusion: Generic alendronate may be considered an effective antiresorptive agent for osteoporosis treatment with a low incidenceof adverse effects

Saran malisorn

Library automation is just not a book inventory where hold, issue and receiving of books by using technological tools and services. Our applied research was found that most of the library administrative functionalities such as ‘Acquisition and Accessioning’, ‘auto Indexing & Classification’ and auto Cataloging (Books & Non books materials)’, inventory with real-time OPAC facilities and many more library science concepts are still missing constructs in Universities/College libraries across the country. In this modern era the concept of eLibrary is more popular because availability and accessibility of digitized content sharing through IT/ICT infrastructure is huge. During our research we found that cognizance of Library automation was completely ignored and focused on only talking and establishment of eLibrary. As we all know that “Physical Library” is not a substitute for “eLibrary”. In fact eLibrary is part of a Physical Library to share authenticated digitized content through IT/ICT infrastructure. After a decade of our applied research in the area of Library science, eventually we recorded a lot of findings based on our survey and discussion with senior researchers and Librarians. Our serious and consistent effort makes to succeeds in designing comprehensively effective and efficient operational strategies to build a “world class Library Automation and Paper less Library Management System” for Universities/College libraries. This paper emphasizes about the comprehensive real-time architecture and operational modules and their effectiveness to achieve the user’s satisfaction (flow of functionalities as per the exact need of the Library Management system). This dealt with how emerging technological tools and services are effectively integrated for designing new strategies in the area of library science includes various automation process and security concepts (using Barcode/RFID). Eventually, our dream comes true in building Use of Emerging Technological Tools and Services to building world class Paper less Library Information &Management System [LIMS]. presently deployed and use of this software product in more than 300 satisfied and client locations in INDIA, this product popularly named as “eLib” by AarGees Business Solution, Hubli, India. Though, our research is still on and continuing for further development to build “Global knowledge sharing Centre”.

Dr. chandrashekhar uppin

Cerebrospinal fluid (CSF) is critical in maintaining brain interstitial fluid balance and providing hydromechanical protection. Lumbar puncture (LP) is a common invasive procedure for obtaining CSF samples to evaluate central nervous system infections and cancers and measure intracranial pressure. While LP is generally considered safe, it is associated with both minor and major complications. Post-LP meningitis occurs in approximately 50% of spinal anesthesia cases and 9% of diagnostic LPs. Additionally, over 70% of diagnostic LPs result in minor bleeding, which can lead to serious outcomes such as spinal epidural hematoma, nerve damage, or paralysis. Significant consequences of LP include headaches and hearing loss; however, other rare complications, such as cerebral herniation and CSF leak syndrome, must be considered carefully. This review synthesizes findings from multiple studies published in PubMed, Google Scholar, and Scopus, highlighting the need for further research on the complications and interventions related to this commonly performed procedure.

Karishma

Learning styles describe how individuals acquire, interpret, and assimilate knowledge differently. The effective use of learning styles is essential for effective classroom education. The three most popular learning styles are kinaesthetic, auditory, and visual. This study pursued to learn more about the preferred learning modes of college students. There were 152 respondents from Baneshwor Multiple Campus, Kathmandu Nepal. The data were collected from first year students of BBS, B.Ed. and BA. The researchers used a scale of learning styles (VAK) with 28 items to accomplish the study's goal, and after confirming its validity and reliability, it was applied to the sample. The results show that there are no statistically significant differences in the types of learning patterns preferred by students. Based on these findings, the study recommends that teachers are encouraged to diversify college teaching strategies and methods to suit the preferred learning styles of their students, particularly new students, in order to motivate them to learn in the college environment and to provide the training needs and requirements necessary to enable them to take individual differences among their students into account when identifying educational goals.

Dr dasarath neupane

Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

Diabetes is a global issue, the diabetes epidemic is expected to continue, and the burden of diabetes causes catastrophic expenditure for healthcare system. The current study aimed to determine the presentation, the clinical feature and cardio-vascular risk factors in patients with diabetes. A retrospective observational study had been conducted in out-patients department at Almustaqpal Almosherq Centre during September, 2013 till September, 2020, the total number of attended out-patients department were 1 024, 820 patients who were selected for this study. A special perform was completed for every patient, which included details about patient’s demographics, points in clinical history, relevant investigations and clinical examinations were recorded. The study reported that out of 820 patients, 66% (n = 538) was female and their age range was between 14 - 87 years with a mean age of 56.53 ± 13.49 years, 96% (n = 791) were clinically diagnosed as type II diabetes, 07% of the patients were diagnosed as pre-diabetes, the duration of diabetes ranged from newly diagnosed to more than 10 years, with 46% (n = 379) of the studied population were more than 10 years diabetes duration, 70% (581) were presented with classical symptoms of diabetes. Initial treatment for diabetes also different in the studied sample, were absent of anti-diabetic medications in 30% (n = 248) of the patients, they refused to start glucose lowering drugs, 34.6% (n = 284) of them have morbid obesity (body mass index is more than 40), 80% (n = 662) have high HBA1c (more than 8 g%), 40.3% (n = 240/596) were uncontrolled hypertension on anti-hypertension drugs, 95.6% (n = 682/713) were controlled on treatment of lipid lowering drugs. This study showing the presentation of diabetes were the common, type II diabetes, at age group between 41 - 66 years about 65%, female sex, with high body mass index, high glycated hemglobulin and uncontrolled hypertension. There is concern that diabetic patients were occurring at a high frequency in younger adults, where longer duration of illness could increase the risk of developing more complications in later life. The rate of coexist cardiovascular risk factors (hypertension, dyslipidaemia and obesity) in Libyan patients with diabetes is highlighted.

Mediterranean journal of pharmacy and pharmaceutical sciences

Mosquitoes conveying Plasmodium store parasites into the skin of the mammalian host. Parasites make a trip through the circulation system to the liver, where they cross a few hepatocytes prior to building up a disease. Inside the last hepatocyte the parasite goes through morphogenesis and afterward abiogenetically partitions to become more than 20,000 blood-infective parasites, called merozoites. On account of P. vivax, P. ovale, and P. cynomolgi, the parasites can stay lethargic in the liver in structures called hypnozoites. The merozoites are delivered once again into the circulation system, where they start the repetitive blood stage. Inside erythrocytes, a little division of parasites separate into male or female gametocytes. These gametocytes are ingested by the mosquito during blood taking care of, where they will duplicate explicitly, in the long run prompting the arrangement of sporozoites

Rukshi naaz

Influenza A virus presents a significant public health burden worldwide, with the 1918 Spanish flu pandemic being the most dramatic example. Swine influenza viruses can be transmitted to humans through occupational exposures and in live pig markets. Novel variants can emerge in pigs because they can be infected by human, avian and swine strains. This study was carried out to determine the seroprevalence and serotypes of swine influenza in pigs from a major slaughter slab in southern Kaduna. Using competitive ELISA and haemagglutination-inhibition (HI) assays, 305 swine sera were analysed. The result showed an overall seroprevalence of 28.20% (n=86), with H3N2 7.87% (n=24) emerging as the most dominant subtype in circulation. Concurrent antibody detection of H1N1 in 5.26% (n=16) was also detected in boar 2.62% (n=8) and sows 2.62% (n=8). This study revealed swine Influenza H1N1 and H3N2 serotypes are in circulation in pigs in Kaduna State, and that reassortment in the instance of co-infection of swine host is possible.

Bitrus inuwa

ABSTRACT The 2006 International Telecommunication Union (ITU) Radio World Conference treaty concluded that all countries should migrate from analogue to digital terrestrial television by June 2015, starting with region one countries, comprising Africa, Europe, the Middle East and the Republic of Iran (Agona & Otim, 2012). The purpose of this research was to explore the technology adoption model (TAM) to address challenges associated with digital terrestrial television migration, and analyse the readiness of South Africa to migrate. A quantitative research was conducted in order to determine the relationship between dependent and independent variables. Digital television offers many benefits for broadcasters, network operators, spectrum regulators, and consumers. In most countries, the transition was slower than expected, even though most European countries managed to migrate. The digital migration is not an easy transition and analogue switch-off can also be much more difficult. Studies have shown that analogue switch off (ASO) needs to be carefully planned and well budgeted for, and it also needs a good publicity campaign which must involve all relevant stakeholders, such as broadcasters, viewers, manufacturers, network operators, manufacturers and retailers. Even though studies conducted previously identified obstacles of digital migration to include; a) lack of awareness b) lack of information, c) influence of politics and d) influence of corruption.

Luyolo mahlangabeza

Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. These studies are required to be conducted in a planned way following the guideline issused by ICH, WHO and or other agencies. Importance of various methods followed for stability testing of pharmaceutical products, guideline issued for stability testing and other aspects related to stability of pharmaceutical products have been presented in a present review.

Prachi barbhaiya

Effective communication between patients and doctors is fundamental to high-quality healthcare, patient safety, and overall satisfaction. However, the onset of COVID-19 has prompted significant shifts in communication from in-room and face-to-face interactions to virtual consults. The impact of this pandemic related change on patient-doctor communication goals, processes, attributes, and environment remains unclear. We undertook a scoping review involving the systematic search of seven academic databases for relevant articles published up to and including June 2021. In total, 47 articles were identified that met the inclusion criteria. We applied the patient-doctor communication framework to guide our deductive thematic analysis of articles included, sorting results from reported studies and position papers into themes and sub-themes. The theme of communication goals highlighted sub-themes related to patient safety, convenience, affordability, and satisfaction; preparation included sub-themes on technology interventions, workforce training, and digital literacy; participant attributes included compassion for doctors and rebuilding trust among patients; and communication process included issues related to telemedicine or video conferencing, challenges with diminished patient privacy, and distractions in the patient's home setting. Finally, the environment theme included insights into doctors' workload, isolation, and anxiety and how changes requiring increases in virtual consults iteratively altered confidence in care provision and communication with patients. Results of the scoping review provide important insights for strengthening virtual patient-doctor interactions, including target areas for training and professional development during and beyond the current pandemic.

Mahuapatra1@gmail.com

In the research described in this paper, we used computer simulations to analyze and compare different types of game strategies in the popular board game Don't Get Angry. Following a brief introduction, we summarized a few previous research papers examining similar board games' game strategies. Next, after a review of the Don't Get Angry game's official rules, we outlined four strategies that can be applied to increase the likelihood of winning. We simulated 50,000 games in which all four players made their moves randomly and 50,000 games where each used a different strategy. We tracked how frequently each player finished first, second, third, or last during the simulations. Furthermore, we recorded how many rounds were needed to complete the game for each player, how many times the players’ pawns were kicked out and returned to their houses by other players, and the number of players’ remaining steps during every gameplay. From the analysis of the recorded data, we could conclude that significant differences exist in the chances of winning the game for the examined strategies when all players use different strategies. The results improve the specific domain knowledge for the Don't Get Angry board game. It may help create more vigorous computer opponents and encourage further study to create a tool for evaluating students' strategic thinking while playing.

Ladislav végh

Background: Intracerebral hemorrhage (ICH) has not been widely investigated in young adults. This study aims to describe the risk factors of ICH with a focus on the possible effect of non-modifiable risk factors, such as genetic factors, to assess the ICH outcomes, and to identify the prognostic factors after ICH among young adult patients. Methods: This prospective and observational study was conducted at two hospitals at Hamad Medical Corporation, Qatar, namely Hamad General Hospital and Alkhor Hospital. The study included young patients (16–45 years old) admitted with ICH between January 1, 2015, and December 31, 2018. Results: We examined 238 consecutive young patients with ICH consisting of 212 (89.1%) males and 26 (10.9%) females. The mean age was 37.8±6.23 years. The most common risk factor found in 187 (78.6%) patients was hypertension (HTN), while 19 (8.0%) patients had no obvious risk factors (cryptogenic). The primary site of bleeding was cerebral cortex (lobar) in 107 (44.96%) patients and then basal ganglia in 97 (40.76%) patients. The in-hospital mortality was 19 (8.0%); the National Institutes of Health Stroke Scale >14 on admission (adjusted OR=2.06; 95% CI=1.448–2.938; p<0.001), Barthel index score ≤40 on admission (adjusted OR=1.09; 95% CI=1.015–1.178; p=0.019), and HTN (adjusted OR=0.075; 95% CI=0.008–0.724; p=0.025) were found to be independent predictors of in-hospital mortality by multivariate analysis. A 1-year follow-up showed mortality in 7 (3.2%) patients and no new events in 139 (63.8%) cases. Conclusion: HTN, smoking, and excessive alcohol consumption are important modifiable risk factors for ICH among young patients in Qatar, requiring early identification and treatment to prevent this dangerous type of stroke. In addition, we recommend conducting further studies focusing on the genetic risk factors of ICH among young adults, particularly those with cryptogenic ICH, to identify whether genetic risk factors are involved.

Karishma

Over the last few years, Libyan scientists and researchers have investigated most of the native wild plants from various regions of Libya. Since tens of years, research groups from Libyan universities, especially at Faculty of Pharmacy and Biotechnology Center, have assessed the native wild plants for their detailed biochemical and pharmacological active composition in order to identify their biologically active compounds with health and therapeutic benefits and economical values. Recent scientific reports stated that several wild Libyan plants carry various bioactive compounds which have a substantial role in treating certain human diseases such as diabetes mellitus, inflammations, microbial infections, cancer, etc

Mediterranean journal of pharmacy and pharmaceutical sciences

The goal of the present study was to investigate the molecular mechanisms that underlie heart andskeletal muscle damage in male Wistar rats weighing 200–250 g in response to a 3-h exposure to 180 mm Hg(5% O2) in the model of severe hypobaric hypoxia. It has been demonstrated that the level of the cardiac bio-marker troponin I in the blood plasma of rats exposed to severe hypobaric hypoxia for 3 h increased signifi-cantly compared to the control group, indicating myocardial injury. At the same time, the administration ofthe HIF-1α transcription factor inhibitor did not affect the plasma level of troponin I. In contrast, the releaseof the non-specific biomarker myoglobin into the bloodstream did not increase in response to hypoxia com-pared to the control animals. In addition, 24 h after the exposure to severe hypobaric hypoxia the serum myo-globin level was significantly lower in animals administered with the HIF-1α inhibitor topotecan than in ratsthat did not receive topotecan. Therefore, it may be assumed that the inhibition of the HIF-1α transcriptionfactor 10 min before exposure to severe hypobaric hypoxia reduces skeletal muscle damage. The mechanismsthat affect the adaptation of heart and skeletal muscles to hypoxia are discussed.

Даниил Федоров

Vehicular adhoc structures (VANETs) handle the Public Key Infrastructure (PKI) and Certificate Revocation Lists (CRLs) for their security. In any PKI structure, the check of a got message is performed by checking if the check of the sender is joined into the current CRL, Verifying the reliability of the certification and standard for the sender. In this paper, it has been propose a Vehicular Digital Hash Gen show up (VDHG) for VANETs, which replaces the dull CRL checking process by a profitable revoking checking process. The renouncing check process in VDHG uses a Private Key Infrastructure (PKI), where the key used in finding the VDHG is shared particularly between On-Board Units (OBUs). In like manner, VDHG uses a novel probabilistic key stream, which extras with OBUs to trade and revive an issue key. VDHG can on a very basic level lessen the data torment in light of the message declaration deferral pulled back and the standard assistance structures using CRL

Dr h shaheen

For utilization of a certain biomass it is necessary to know its chemical composition. The present study is qualitative crude chemical analyses of nutritional value (crude compounds) such as acidity, starch, carohydrates, iron and calcium etc. from stem extracts of Tinospora cardifolia, Centella asiatica, Clerodendrum inerme and leaf extract of Ocimum sanctum, Lawsonia inermis and Piper nigrum were conducted and also separate the pigments by TLC methods. The results revealed that Tinospora cardifolia, biomolecules like starch and carbohydrates were present and elements like iron and calcium were absent. In Centella asiatica indicated the absence of biomolecules like starch and carbohydrates and only one molecules, i.e., calcium is present and iron is absent. Similarly, in Clerodendrum inerme, biomolecules like starch were absent and carbohydrates were present. Both the elements iron and calcium were absent in Clerodendrum plant extracts. In Ocimum sanctum, starch is absent carbohydrates are present, iron and calcium are absent. In Lawsonia inermis, the results are similar to Ocimum sp. i.e., only carbohydrates are present remaining starch, iron and calcium are absent in Ocimum leaf extract. Interestingly, in Piper nigrum, all chemical compounds are totally absent. Related to pigments analysis highest distance travelled pigments are carotenoids (4.3 cm) in O. sanctum and highest numbers of pigments were founded in C. inerme with six pigments and least number of pigments was recorded in O. sanctum (four) and L. inermis (four). Meanwhile, the highest Rf value recorded in O. sanctum and P. nigrum with 0.97 (chlorophyll a). Among the seven pigments in six species carotenoids, chlorophyll a and xanthophylls are common to all species but chlorophyll b, lutein, anthocyanin and lawsonin are rare to occurs in these six species for example Lawsonin occur only in P. nigrum.

Veerabhadraswamy al

ROS (Reactive Oxygen Species) production via oxidative stress leads to selective neuronal degeneration and finally results in neurodegenerative diseases. PD (Parkinson’s disease) is one of the second most common neurodegenerative disease caused by overproduction of ROS due to the activity of xanthine oxidase. XO activity inhibitors may prove to be promising antiparkinson agents. Present investigation describes the synthesis and characterization of fluoro substituted pyrazolyl pyrazoline derivatives using spectrometer and 1HNMR spectra. Molecular docking studies of NAP1-NAP5 derivatives were performed in silico using molecular docking software. The resulting dock score in terms of D score has been compared with the standard XO inhibitor i.e. Allopurinol and Oxypurinol. The in silico approach used to study the Drug and Enzyme interaction using docking mechanism. Results indicated that the NAP derivatives accounted for better region specificity towards XO. It shows the strong binding interaction of ligand and receptor calculated on the basis of D score; hence the D score shows highest affinity. Overall score tabulation for D score as 2NAP1: -101.78; 2NAP2: -118.32; 2NAP3: -99.921; 2NAP4: -105.22; 2NAP5: -101.56; accordingly with the comparison of standard ligand molecule i.e. Allopurinol: -37.016 and Oxypurinol: -37.233.

Dr. wahul umesh b

Background and Objectives: The complications of type 2 diabetes mellitus (T2DM) can occur in some organs, such as the heart, blood vessels, eyes, kidneys, and nerves. Stroke, one of such complications, is increasing every year. This study aims to investigate the prevalence of and risk factors for stroke among T2DM patients in Qatar. Methods: This was a secondary post hoc analysis of collected data from our previous study titled “Association of Vitamin D deficiency with dyslipidemia, glycemic control, and microalbuminuria in patients with T2DM in Qatar.” Results: The prevalence of stroke among our patients was 3.8%. A comparison between stroke and no-stroke groups showed a significant association between stroke and other diseases, namely, chronic kidney diseases (CKD) (p=0.007), coronary artery disease (CAD) (p=0.010), peripheral vascular disease (PVD) (p<0.001), retinopathy (p=0.044), prolonged duration of diabetes mellitus (DM) (p=0.041), glycated hemoglobin (HbA1c) (p=0.006), and a high serum creatinine level (p=0.003). In the multivariate analysis, we identified the following variables as independent risk factors for stroke in patients with T2DM: male gender, CKD, CAD, PVD, high HbA1c, a high creatinine level, and prolonged duration of DM. Conclusion: The prevalence of stroke among T2DM patients in Qatar was around 3.8%. The main risk factors were male gender, CKD, CAD, PVD, high HbA1c, prolonged duration of DM, and a high level of creatinine.

Karishma