English Corner extracurricular activities are one of the choices for students to be able to learn English with more fun. Through the English Corner extracurricular program, the Madrasah provides provisions for its students to face the era of the industrial revolution 4.0. The purpose of this research is to add insight and to know the mechanism of the English corner extracurricular through the development, implementation, assessment, and evaluation of the English corner extracurricular in the 4.0 revolution era at MI Roudlotul Ulum Banyuwangi. This type of research is qualitative research with a descriptive design. Data collection techniques using interviews, observation, and documentation. Data analysis used the concept of Miles and Huberman. The validity of the data was measured by means of triangulation of sources and techniques. The results showed that 1). The development of the English corner extracurricular in facing the 4.0 industrial revolution pays attention to human resources, needs, infrastructure, talents, and interests. 2). The implementation of the English corner extracurricular is almost the same as learning in general and is made more relaxed so that it is more comfortable in its implementation. 3). This English corner extracurricular assessment uses a written manual assessment, after which it is recapitulated and entered into the Digital Report Card Application (ARD). 4). This English corner extracurricular evaluation is carried out every six months or at the end of the semester, taking into account the development and implementation that was carried out in the previous semester.

Educare: journal of primary education

Kepatuhan terhadap terapi farmakologi merupakan kunci utama pengobatan penyakit diabetes, tetapi belum mendapat perhatian penuh oleh para klinisi. Beberapa systematic review faktor kepatuhan telah dilakukan di beberapa kawasan negara. Namun, tidak menampilkan studi dari Indonesia. Penelitian ini bertujuan untuk meninjau secara sistematis faktor-faktor yang dapat memengaruhi kepatuhan minum obat diabetes melitus (DM) di Indonesia. Systematic literature review dilakukan melalui pencarian pada database jurnal Nasional (Garuda dan Sinta) dan Internasional (PubMed dan Science Direct). Penelitian yang sesuai dengan kriteria inklusi dan dipublikasikan pada Januari 2011 – Desember 2020. Kualitas penelitian dinilai menggunakan panduan SQAT. Metode pelaporan penelitian menggunakan pedoman PRISMA. Faktor kepatuhan diklasifikasikan berdasarkan domain faktor kepatuhan menurut World Health Organization (WHO). Sebanyak 370 artikel ilmiah penelitian dari database Garuda (n=36); Science Direct (n= 108); PubMed (n= 18); Sinta (n= 208). 341 artikel penelitian dieksklusi, 29 artikel skrining full text, dan 16 artikel penelitian memenuhi kriteria inklusi untuk dianalisis. Faktor yang memengaruhi kepatuhan minum obat diabetes adalah faktor sosial dan ekonomi (penghasilan, tingkat pendidikan, dan pekerjaan), faktor tenaga dan sistem kesehatan (tenaga kesehatan), faktor terapi pasien (jumlah obat diabetes, frekuensi minum obat, dan produk obat), faktor penyakit pasien (kadar gula darah, durasi penyakit), faktor pasien (jenis kelamin, faktor emosional, dukungan sosial, tingkat pengetahuan, dan kepuasan pengobatan), dan faktor pengelolaan penyakit (konseling dan edukasi farmasi). Faktor yang memengaruhi kepatuhan minum obat DM di Indonesia sangat beragam, dan multi faktor. Faktor tersebut dapat berfungsi sebagai target intervensi yang relevan. Para klinisi perlu mempertimbangkan penyesuaian frekuensi minum obat dan pemberian dukungan sosial kepada pasien DM.

Much ilham novalisa aji wibowo

Presurgical Nasoalveolar molding have become an important procedure before proceeding with the surgical procedures for cleft lip and palate patient. PNAM reduces the size of the cleft which helps in better approximation and minimal scar formation.. To achieve this all proper tray selection is necessary and is a basic step in taking the impression of an infant. This article attempts to describe the various impression trays that can be used for the cleft patients routinely.

Apurva

Background: Uterine leiomyoma is the most common benign smooth muscle tumor of unknown aetiology. Progesterone may contribute to leiomyoma growth through the induction of B-cell lymphoma-2 (BCL-2) protein in leiomyoma cells. This study aims to determine the patterns of Bcell lymphoma-2 (BCL-2) and progesterone receptor (PR) expression in uterine leiomyomas seen at LTH, Ogbomoso, over a five-year period using immunohistochemical techniques.Methods: This was a hospital-based retrospective study of histologically diagnosed leiomyomas in the histopathology department of a teaching hospital between January 2012 and December 2016. A total of 141 cases of uterine leiomyomas were semi-quantitatively analysed immunohistochemically for PR and BCL-2 antigens. Results: Immunohistochemical analysis showed that out of 141 cases studied, 74 (52.5%) and 118 (83.7%) were positive for BCL-2 and PR, respectively. Among the 141 cases, 23 (16.3%) were negative for both PR and BCL-2. There was a moderate positive correlation between the immunohistochemical expression of BCL-2 and PR antigens, with a p-value < 0.001 (Pearson correlation = 0.563). Conclusion: This study showed that the majority of women with leiomyomas expressed both progesterone receptor and B-cell lymphoma-2 antigens. Therefore, selective women with leiomyomas could benefit from progesterone receptor modulators instead of undergoing invasive procedures such as myomectomy or hysterectomy.

Karishma

Cystic fibrosis is a challenging disease which creates many complications. The impact caused from cystic fibrosis on an adolescent is a challenging phase for their lives. Negative impacts like the society’s pressure, anxiety and depression are few common reasons that are being unspoken and ignored due to complexity of the disease. This study is aimed to identify the necessary gaps and educate the necessary policy makers and CF center health care team to have a better understanding about the context of the aftermath of cystic fibrosis and enhance better patient care. More over this systematic review also points out the main trends in this field of study. Qualitative study and quantitative are prominently used research methods to gain an understanding the about the gaps in the research. However, there is still a scarcity of quantitative and mixed research methods. Furthermore, limitations such as language, cultural influences were identified whilst going through the analysis. Overall through the information given in the following in this study more information regarding that warrants answers can be identified which will lead to proper care towards the teenagers who suffers from cystic fibrosis.

Chanitha pemasena

Background: COVID-19-positive patients are at increased risk of adverse clinical outcomes, with type 2 diabetes cohorts at substantially higher risk compared to the general population. The additional role of diabetic and non-diabetic polypharmacy in these patients' clinical course has remained unexamined. In this study we have comprehensively examined the role of polypharmacy in the determination of mortality outcomes in patients with COVID-19 clinical syndrome. Methods: We retrospectively examined case notes and electronic records of N = 497 patients with type 2 diabetes and COVID-19 infection. We ascertained the number of medications each patient was taking and used this to categorize the study cohort into diabetic [n = 246] (5 or more diabetic medications), and non-diabetic polypharmacy [n = 251] (5 or more non-diabetic medications). The primary outcome was the need for intensive care admission between the two groups. Results: In patients with “non-diabetic polypharmacy” (>5 medications), advancing age, and higher HBA1c levels, were associated with increased risk of Intensive care admission (OR 1.06 [CI 1.03-1.07], P = <0001), (OR 1.01 [CI 1.01- 1.20], P 0.017), respectively. Patients taking 5 or more non-diabetic medications had an increased likelihood of admission into the intensive care unit compared to those on lower medication thresholds (OR = 1.7; CI = 1.1 to 1.3; p-value = <0.0006). Conclusion: In an inpatient cohort of type 2 diabetic patients with COVID-19, non-diabetic polypharmacy was associated with a multiplicative risk of intensive care admissions. This will necessitate the need for periodic medication reviews in these cohorts of patients to mitigate these potential risks and improve clinical outcomes.

Karishma

Diaspora groups across the world have been known for adopting and inventing processes and forms of ‘homemaking’ in their host lands. This article brings into focus the methods of homemaking assumed by the Indo-Surinamese Hindustani diaspora in the Netherlands, which owes its origin to colonial dispersal. Considering their status as a ‘twice-migrant’ diaspora, the process may appear to be distinctly difficult for the Hindustanis, a position this article seeks to examine. The article interrogates the notion of homemaking in the case of the Hindustanis through ethnographic conversational interviews of Indo-Surinamese interlocutors—a unique perspective based on personal histories and everyday experiences.

Roshni sengupta

The present study reveals that the enriched aerobic cultures of indigenous microbes can be used successfully for decolorizing dye effluents. Physico-chemical analysis of dye effluent revealed high load of pollution indicators. Textile dye effluent and contaminated soils were collected and analyzed for selection of suitable bacteria for dye degradation. The residual bacterial load was found to be in the range of 108 cfu/mL. Six bacterial strains viz., two species of Bacillus, two species of Klebsiella,, one species each of Planococcus and Micrococcus luteus were isolated. The best two dye degraders namely species of Planococcus and Bacillus were further optimized for the effect of carbon and nitrogen source, pH, temperature and percentage of inoculum. The optimized conditions for both the isolates of Planococcus sp. and Bacillus sp. were used in bio-decolorization studies of textile effluent. More than 50% of decolorization was achieved within 4 d of incubation. After 6 d of incubation, decolorization was achieved above 80%. The isolates Planococcus sp. and Bacillus sp. exhibited maximum decolorization ability at pH between 5-8 and temperature 37C. Moreover, 10% (v/v) inoculums, glucose and peptone as carbon and nitrogen sources were found to be the optimum for decolorization. Both the isolates showed highest decolorization percentage of Coractive Blue 3R dye effectively during optimization and more interestingly showed consistent decolorization of textile dye throughout the study.

Dr. saranya devi k

Indoor thermal comfort and air quality are essential for occupant well-being, while simultaneously optimizing energy consumption in buildings. Achieving a balance between these factors presents a significant challenge, as indoor environments are dynamic and energy demands fluctuate. By modifying ventilation rates in response to real-time data, demand-controlled ventilation systems can reduce energy consumption and enhance indoor comfort and air quality. However, optimizing these systems with advanced predictive models remains a complex task. To address this challenge, this publication proposes a Dual-Stream Multi-Dependency Graph Neural Network (DMGNN)-based energy-efficient ventilation management technique that maximizes indoor air quality and thermal comfort. The suggested method seeks to enhance thermal comfort and air quality by maximizing heating, ventilation, and air conditioning (HVAC) operations while reducing energy consumption. Initially data are collected from an Indoor Air Quality Monitoring Dataset. The DMGNN is employed to capture the complex dependencies between environmental factors such as temperature, humidity, and CO2 concentrations, considering both temporal and spatial relationships. Implementing the proposed system and evaluating it through simulations in various building environments demonstrates notable improvements in thermal comfort, indoor air quality, and energy economy. The suggested system’s performance is contrasted with that of other current methods, showing superior energy efficiency and optimization of both indoor air quality and occupant comfort. This study presents an innovative, scalable framework for smart building management, promoting sustainable energy solutions.

Dr h shaheen

Natural products, the most significant source for pharmaceutical development, have been investigated and utilized to alleviate diseases since early human history. The currently accepted modern medicine from different natural products has gradually developed over the years and is God's gift in the sense of traditional knowledge. Trustful humanity believes that drugs can cure every ill of natural origin. Natural medicines, prevalent in holy books, folklores, Materia medica and other historical literature, have become an essential domain of modern pharmaceutical sciences. Natural compounds from terrestrial and marine organisms have been extensively used to treat many diseases in their natural form or as a template for synthetic modification. Several of these natural products have shown biological and pharmacological activities and serve as the starting point in the development of modern medicines. Screening of crude plant extracts opens the door to the discovery of novel bioactive compounds, and elucidation of their structures leads towards new synthetic preparations, which can be administered in reproducible, accurate doses for particular therapeutic purposes. However, what is needed are rapid screening techniques, structure-based design, bioactivity-safety evaluation, extraction and isolation, and clinical trials for drug development under innovations, which will share the profit of products derived from natural origin. The government sector, industries, and academic institutions also play an essential role in developing biological drugs for human health enhancement. This book comprises four chapters. The first chapter is related to urolithiasis. In this chapter, the types of urinary stone formation in humans, their mechanism, current antiurolithiatic strategies and their complications are discussed precisely and comprehensively. Chapter two declares urinary stone treatment in early civilisation. The third chapter is about globally used antiurolithiatic plants. This chapter is a treasure trove of information covering the importance of plants in combating urolithiasis, their diverse pharmacology, and a comprehensive list of 888 antiurolithiatic plants from 144 families used in 55 countries. The tabular format provides a clear understanding of their historical background, mechanism of action, therapeutic spectrum, and formulations with doses. Hopefully, this book will not only be helpful for the general public but also attract the scientific world to antiurolithiatic drug discovery. This valuable ethnopharmacological information will provide opportunities for the future research and development of new natural antiurolithiatic compounds. We extend our heartfelt gratitude to all the teachers, colleagues, and institutions whose unwavering support and encouragement made this book possible. We reserve a special thanks for the acquisition Editor of LAP Lambert Academic Publishing, Germany, whose inspiration and support were invaluable.

Dr. salman ahmed

Lymphoma, the most common form of blood cancer, affects primarily the intricate network of tissues and organs known as the lymphatic system. Globally, it ranks among the leading causes of cancer-related deaths. Although conventional therapies have led to significant advancements, they are accompanied by adverse side effects and present challenges in cases of multidrug resistance, refractory patients, and relapses. This highlights a pressing need for innovative treatment approaches. Extensive research on the anti-lymphoma properties of natural compounds has particularly focused on marine organisms as valuable sources for potential medicinal agents. Among these, anticancer peptides have garnered attention due to their multiple beneficial effects against cancer, coupled with reduced toxicity to normal cells. This review focuses on the molecular mechanisms underlying the anti-lymphoma effects of marine peptides, examining the diverse pathways through which these peptides impact physiological processes. Key effects include modulation of cell viability, induction of apoptosis, cell cycle arrest, antimitotic activity, immunotherapeutic properties, disruption of mitochondrial function and induction of oxidative stress, cancer cell membrane destruction, and interference with microtubule stability. The review also highlights the antibody–drug conjugates (ADCs) derived from marine peptides and their synergistic effects with other anti-lymphoma medications. This knowledge should inspire future study and development of these prospective therapeutic modalities and hasten the investigation and creation of novel lymphoma remedies derived from marine sources.

Dr. salman ahmed

The process of globalisation has made an unprecedented change in indigenous people's lives worldwide. However, the degree of exploitation and marginalisation vary from State to state and Adivasi tribal group to group. It examines very young, and older people are representing the highest number in the study areas. More than 73 per cent of Adivasi tribes are illiterates. The majority of families practice nuclear and have below three family members. Fifty-seven per cent of families have tiles roofs to their houses. 70% of respondents are cultivators (farmers), and 81% possess landholdings. More than 64 per cent collect minor forest produce. 68% of respondents earn less than 20k annual income. 90% of women participated in deciding their economic and family affairs—Majority Adivasi tribal suffering from anaemia, TB, BP and Diabetes. Adivasi tribals staple food is rice, followed by jowar—91% of respondents practising non-tribal traditional marriage system. The Government should take steps towards developmental activities in all villages, including water supply, bus services and roads. The Government has to take an integrated approach to develop Adivasi tribes in all aspects they need and participate in.

B suresh lal

In the modern world, Tuberculosis (TB) is regarded as a serious health issue with a high rate of mortality. TB can be cured completely by early diagnosis. For achieving this, one tool utilized is CXR (Chest X-rays) which is used to screen active TB. An enhanced deep learning (DL) model is implemented for automatic Tuberculosis detection. This work undergoes the phases like preprocessing, segmentation, feature extraction, and optimized classification. Initially, the CXR image is preprocessed and segmented using AFCM (Adaptive Fuzzy C means) clustering. Then, feature extraction and several features are extracted. Finally, these features are given to the DL classifier Deep Belief Network (DBN). To improve the classification accuracy and to optimize the DBN, a metaheuristic optimization Adaptive Monarch butterfly optimization (AMBO) algorithm is used. Here, the Deep Belief Network with Adaptive Monarch butterfly optimization (DBN-AMBO) is used for enhancing the accuracy, reducing the error function, and optimizing weighting parameters. The overall implementation is carried out on the Python platform. The overall performance evaluations of the DBN-AMBO were carried out on MC and SC datasets and compared over the other approaches on the basis of certain metrics.

Dr h shaheen

Chronic kidney disease is a public health problem affecting people worldwide. This study was aimed to examine the characteristics of patients with chronic kidney disease and to identify prevalence of drug-related problems among Libyan patients. This is a descriptive retrospective study carried out in Southern-west part of Libya, Sebha City. Information abstraction forms were used for collection of data. The investigators reviewed the medications, medical records and laboratory data to identify drug-related problems.1 000 patients' files during 2019-2020 were examined and only 120 files were selected for this study. The majority of the participants were male (73, 61.0%) and the mean age was 56.1 years. 576 comorbidities among the selected patients were identified (73.61%) and the average number per patients was 4.8 concurrent diseases. There were 1 350 medications prescribed and the average of prescribed drugs per patient was 11.25. The majority of patients use more than 10 drugs (64, 53.3%) and the average length of staying in the hospital was 5.58 days. 502 drug-related problems were identified with an average of 4.18 per patient. Untreated conditions such as Hyponatremia and anemia were the highest rate of drug-related problems identified (199, 39.6%) followed by improper drug selection (82, 16.3%) such as cefotaxime, vancomycin and aminoglycoside for chronic kidney disease and drug use without indications such as antibiotics (68, 13.5%) and over-therapeutic dose such as metoclopramide(63, 12.5%). In conclusion, all the patients have polypharmacy and the majority have comorbid conditions and chronic kidney disease with frequent drug-related problems, thus, to lower the incidence rate of drug-related problems, therapeutic interventions are needed. Subsequently, it is a crucial to involve clinical pharmacist in hospital to improve the care of patient with chronic kidney disease.

Mediterranean journal of pharmacy and pharmaceutical sciences

The present study aims to shed some light on the gains from consolidation exercise in terms of profitability of banks. Through the application of paired t-test, we arrived at the result that the consolidation of banks did improve the profitability of banks in India. The increase in profitability of banks under study is due to an increase in employee turnover and the subsequent reduction in operating expenses. Merger and acquisition programmes in Indian banks cannot be regarded as a false step if the benefits of it accrue to all stakeholders.

Akhil antony

Background: This study investigated the utilization of consumer health informatics in health promotion among the staff of tertiary institutions in Rivers state. Subjects & Methods: A cross-sectional descriptive research design was used. Two research questions guided this paper. The population of this paper comprised all the 13,046 staff of tertiary institutions in Rivers state. A sample of 1226 staff was drawn using multi-stage sampling techniques. An instrument titled, “Utilization of Consumer Health Informatics in Health Promotion Questionnaire” (UCHIHPQ) was adopted for data collection. The instrument was validated and reliability yielded an index of 0.80. Mean and Standard Deviation statistics were used to answer the research questions. The statistical analysis was performed with the use of SPSS v23. Results: The result revealed among others that to a very large extent, the respondents accepted that consumer health informatics was used to improve their nutritional and physical health status. Conclusion: It was therefore concluded and recommended among others that staff of tertiary institutions in Rivers state should regularly use intelligent informatics applications to attain a healthy balance between self-reliance and seeking professional help concerning nutritional and physical health matter

Fxintegrity publishing

This Research Paper elucidates the challenges faced by teachers while teaching learners with learning disability. This has been conducted as a research study by the Research Scholar which explores multifaceted aspects of ‘challenges based on the responses given by the participants in the interview. It is a study designed to identify multifaceted dimensions of challenges faced by teachers while teaching learning disabled children. The research study analyzes the impact of challenges on teachers and how they are overcoming these challenges. This descriptive study was carried out as qualitative research under an Indian scenario based on Primary data available on the subject. The research enquiry focused on several research questions: What is the teacher’s understanding of learning disability? What challenges do remedial teachers face while teaching children with learning disability and how do they overcome them? What are the teaching approaches and methodology used to teach children with learning disability? The study will try to highlight the challenges faced by teachers to address them in front of the school administration. The challenges faced by teachers while teaching learning disabled children, i.e., ‘Teaching material and Curriculum structure’, ‘Behavioural issues’, ‘Lack of time’, ‘Parental expectations and Parental issues’, ‘Motivation’, ‘Self-esteem’ and ‘Emotional issues. The methods used to overcome these challenges were pointed out and analyses. Each teacher was using their own methods to tackle these challenges but some methods were used generally and an individual tailored method were developed and used according to respective learners.

Hashir ahammed a v

Parkinson’s disease is a common movement disorder associated primarily with oxidative stress-mediated degeneration of dopaminergic neurons. Earlier studies showed that Sorghum bicolor-based supplement (SbS) exhibited antioxidant and neuroprotective activities and might likely rescue the death of dopaminergic neurons in Parkinson’s disease. This study examined the effect of SbS on rotenone-induced Parkinsonian-like motor deficits in rats and the involvement of oxidative stress and pro-inflammatory cytokines. Rats were divided into six groups and treated orally with sunflower oil (vehicle-control), rotenone (2.5 mg/kg) alone or in combination with each dose of SbS (50, 100, and 200 mg/kg) and levodopa-carbidopa (10 mg/kg) on an alternate day for 28 days. The changes in motor functions were evaluated on day 28 and the brain concentrations of oxidative stress biomarkers and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) were determined. Rotenone caused motor deficits by impaired locomotor activity in the open field test and induced catalepsy in the bar test, which were attenuated by SbS. Rats pretreated with SbS had reduced brain levels of malondialdehyde, nitrite, and pro-inflammatory cytokines compared to rotenone controls. SbS mitigated rotenone-induced depletion of reduced glutathione and antioxidant enzymes in the rat brain. The results suggest that SbS ameliorated rotenone-induced Parkinsonian-like motor dysfunctions by reducing neuronal oxidative stress and pro-inflammatory cytokines in rats.

Mediterranean journal of pharmacy and pharmaceutical sciences

Cet article porte sur l’ouvrage Le ventre, le pain ou la cendre de Tchicaya U Tam’si. À partir des approches linguistique, stylistique et sémiotique, nous avons tenté de montrer, dans notre analyse, en quoi l’écriture de ce recueil construit des stratégies discursives propres à retenir l’attention du récepteur. À cet effet, nous avons relevé deux principales figures de rhétoriques à savoir, l’emphase et l’hyperbole. Ces deux procédés de style produisent d’une part un effet d’insistance du procès poétique ; et de l’autre, un effet d’amplification du langage poétique.

Assanvo

Cardiovascular drugs constitute one of the largest and most widely used among other diseases and cardiovascular drug market has largely been exploded . Although these drugs have the potential to significantly improve the treatment of various cardiac diseases. They are potent agents with potential for serious adverse effects, toxicity and drug interactions. Newer agents are considerably costly than older drugs and, therefore, cost-effective strategies must be developed. Thrombolytics are pharmacological agents come from bacterial origin as streptokinase and staphylokinase or from human origin as urokinase or t-PA. Thrombolytics are used to restore blood flow to infracted artery quickly. Only streptokinase, alteplase, reteplase and tenecteplase are approved by US-FDA for treatment of ST-elevation myocardial infraction (ST-EMI) [3]. This reopens blood vessels after their occlusion and prevents tissue necrosis. Although, the safe and effective use of each of these drugs requires a thorough understanding of appropriate patient selection, drug timing, dosing regimens and monitoring parameters. The greatest benefit to risk ratio for specific drugs is seen in certain subsets of patients the complexities of cardiovascular drug therapy illustrate the need for an in depth current knowledge of clinical trial evidence.

Mediterranean journal of pharmacy and pharmaceutical sciences