Malignant melanoma is the most dangerous type of skin cancer. It is becoming more common globally and is increasingly resistant to treatment options. Despite extensive research into its pathophysiology, there are still no proven cures for metastatic melanoma. Unfortunately, current treatments are frequently ineffective, costly, and have several adverse effects. Natural substances have been extensively researched for their anti-MM capabilities. Chemoprevention and adjuvant therapy with natural products is an emerging strategy to prevent, cure or treat melanoma. Numerous prospective drugs are found in aquatic species, providing a plentiful supply of lead cytotoxic chemicals for cancer treatment. Anticancer peptides are less harmful to healthy cells and cure cancer through several methods, such as altered cell viability, apoptosis, angiogenesis/metastasis suppression, microtubule balance disturbances and targeting lipid composition of the cancer cell membrane. This review addresses marine peptides as effective and safe treatments for MM and details their molecular mechanisms of action.

Dr. salman ahmed

cASUARINA EQUSITIFOLA IS A FAST GROWING EVERGREEN TREE GROWN BY FARMERS UNDER AGROFORESTRY SYSTEMS IN tAMILNADU state of Southern India

Dr. saranya devi k

Health tourism is a visit made to different regions in order to improve the physical well-being of the person. Medical tourism, on the other hand, is the sub-branch of health tourism and it is a form of travel that is used for medical treatment and also the tourism activities of the country visited. Under the name of medical tourism in women's health; cosmetic surgery, reproduction, birth, IVF, gynecological treatments, abortion, abortion and newborn care travels are included. It has been observed that many women travel around the world and in Turkey for these reasons and medical tourism has an important place in terms of women's health. The purpose of this review is to examine the impact of medical tourism on women's health in line with the literature

Reyhan aydin doğan

Today, the tourism industry has become richer and sophisticated. It involved various businesses and has given multiplier effect towards the society. One of dominant business activity in this sector is event management. It also touches various kind of business e.g. shopping center. Related to this, one of activity that has full support from the ministry of tourism in Indonesia is Culinary and Shopping Festival 2016. This event is being held from 27 September 2016 up to 27 October 2016 in many provinces in Indonesia. Data that is being collected to answer the research is being distributed to various visitors and specifically to student of UPH Medan. Hopefully from the data collection, the analysis will answer what kind of motives is to come to event. Whether the visitor coming for the culinary and shopping festival or for another event will be answered from the study. Therefore combining the data with how the tenant expectation can show the relationship between visitor motives and the festival.

L

Introduction: In Bangladesh, diabetes mellitus (DM) is a significant health concern contributing to numerous complications that enhance the mortality risk. This study aims to examine the impact of lifestyle patterns, socioeconomic conditions, and comorbidities among diabetic patients to establish valid associations between variables. Methods: A cross-sectional study was carried out among 450 patients with diabetes mellitus at the outpatient department of different hospitals in Bangladesh. Data collection was done through face-to-face interviews using a structured questionnaire. Results: The study analyzed sociodemographic and lifestyle traits among diabetic patients, categorized by gender and results were based on unadjusted analysis. Men had a higher prevalence of being married (99.4%) compared to women (97.9%). Women were more common in rural areas (67.5%) and less likely to own smartphones (12.3%, vs 24.7% for men). More women were overweight (31.2%) and owned house (92.1%). Clinical symptoms showed no significant gender associations except for headaches, more prevalent in women (OR=0.65; p=0.034). Women had a higher prevalence of cardiovascular disease (48.3%, vs 35.4% for men, OR=0.59; p=0.009), while kidney dysfunction was more prevalent in men (16.5%, vs 9.6% for women, OR=1.86; p=0.032). Allergic problems (20.5%, OR=0.40; p=0.014) and asthma (5.5%, OR=0.22; p=0.029) were more common in women. No association was observed in the occurrence of ulcer with the respondents’ gender. Regarding lifestyle, 50.7% of respondents consumed rice more than once daily, 71.8% did not smoke, and most (59.1%) had a normal BMI. Conclusions: Based on our study findings, men should focus on renal health by refraining from high-glycemic meals, while women should concentrate on managing their weight and cardiovascular health by utilizing modern healthcare facilities.

Arafat hassan razon

Tuberculosis (TB) is an infectious disease caused by bacteria called Mycobacterium tuberculosis. The disease mainly affects lungs and causes pulmonary tuberculosis. It can also affect intestine, meninges, skin, bones and other tissues of the body. Although the drugs alone can cure TB, it still remains a major public health problem worldwide. The aim of the study was to assess the quality of life and medication adherence in TB patients. The Quality of life was assessed using SF-36 in patients receiving DOTS treatment in initial or continuous phase while the medication adherence was analyzed using Morisky Green Levine Scale. Subjects were also counselled about their disease during their first visit and a follow up was done after a month. A total of 152 subjects were enrolled in the study of which majority of the subjects had Pulmonary TB (55.26%). Diabetes was found to be the most common comorbidity followed by HTN. The average Physical Component Summary (PCS) and Mental component summary (MCS) were found to be 44.34 and 39.60 respectively. Females had a better quality of life scores compared to males. High adherence was seen in 32.24% of patients while 28.29% had low adherence. Follow up was done for 135 subjects. 15 subjects defaulted and 2 of them died. There was a significant increase in the QoL scores and medication adherence after one month. A significant association was found between the Physical functioning (p=0.001) and emotional wellbeing (p=0.01) with Duration of treatment indicating that subjects who had completed more than one month of their treatment had marked improvement in Physical functioning and emotional well-being scores

Dr mahendrakumar r

Self-medication with antibiotics is becoming a trend that threats the health systems worldwide through developing bacterial resistance which is associated with high health care costs and increased rate of morbidity and mortality. The main objective of this study is to assess antibiotic self-medication practice among Libyan university pharmacy students. This is a cross-sectional study conducted among pharmacy students at Sabratha University in the western region of Libya. A validated questionnaire was used to collect relevant data which were statistically analyzed. A total of 170 undergraduate Pharmacy students participated in the study during spring 2021. About 80% of the participants reported the use of antibiotics without consulting a physician. The major reason for using antibiotics was to get a quick relief of emergency conditions which was reported by 35% of the students. About 25% of the students used antibiotics to relieve their pains and aches. The most commonly used antibiotic was amoxicillin (55%). Most antibiotics were obtained over the counter from community pharmacies (85%). Half of the participants were not sure if they can advise patients to use antibiotics without a prescription, although 60% of them believed that it was good practice. In conclusion, prevalence of antibiotic self-medication among university pharmacy undergraduate students is high. Thus, serious interventions are required to ensure safe and effective use of antibiotics among the population in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

The city that never sleeps, a vibrant tapestry of dense neighborhoods and relentless energy, has long grappled with the pervasive challenge of air pollution. The very dynamism that defines the city – its traffic, buildings, and industry – contributes to ambient concentrations of fine particulate matter (PM2.5) and ground-level ozone (O3), pollutants known to exact a heavy toll on public health. [1-3] An extended analysis of environmental health data from 2005 to 2019, meticulously compiled by the town Department of Health and Mental Hygiene (DOHMH), offers a crucial lens through which to view the city's journey: a narrative marked by significant public health victories interwoven with stark, persistent environmental injustices. [4] This fifteen-year period reveals not just the efficacy of targeted interventions but also the deeply entrenched disparities that continue to leave vulnerable communities uneasy. Thus, the aforementioned challenge provides a very important lesson to address similar problems around the globe, especially in the crowded urban areas.

Karishma

Identifying the targets for improving antimicrobial prescription and development of antimicrobial stewardship interventions can better serve to combat the situation of antimicrobial resistance. The primary objective was to determine the prevalence of antimicrobial use at tertiary care teaching hospital with both acute and long-term care patients. A periodical point prevalence survey was done in a tertiary care hospital of South India during 2019 using manual and webbased GLOBAL-PPS tool. Of 945 patients eligible for the study, 645 (69.5 %) received at least one antibiotic, with highest rates in the adult surgical ward and pediatrics. Of 645 therapeutic antibiotic prescriptions, 58.6% prescriptions have an infectious indication of them, 62.6% are community-acquired infections. Third-generation cephalosporins were the most prescribed antibiotics. The prevalence of antibiotic use is very high, and our study evidence that the country needs a robust antimicrobial stewardship intervention program.

Vineela chadalavada

Project management plays significant roles to the success of the project. The aim of the study is to review and analyze latest literature on the effects of triple constraints on the project outcome. The study is based on the secondary method whereas literatures are collected form the google scholar ranging from 2010 to 2023. After reviewing the literature, the study concludes a number of findings. The quality of the project is highly depended on the time and budget. However, inadequate management, stakeholders involvement are also play crucial roles towards project success. The study concludes a number policy recommendations.

Nazim ullah

Melioidosis is an infection that causes high morbidity and mortality. Predisposing risk factors include diabetes mellitus (DM) and immunocompromised state. We report a case of septic shock secondary to bacteremia caused by Burkholderia pseudomallei in a patient who is supposed to be previously healthy and subsequently diagnosed with DM and glucose-6-phosphate dehydrogenase (G6PD) deficiency. He completed 17 days of intravenous antibiotics followed by a 12-week course of oral trimethoprim/sulfamethoxazole. We postulate that G6PD deficiency could be a risk factor for melioidosis.

Karishma

Background: Irritable bowel syndrome (IBS) is a very common gastrointestinal dis-order worldwide, but research regarding this disease is rare in Bangladesh. This studyaimed to assess the prevalence of IBS and its associated risk factors among universitystudents in Bangladesh.Methods: This is a cross-sectional study. A total of 300 randomly selected partici-pants were included in this study. By using a structured questionnaire and anthropo-metric methods, we collected all the required data for our study. The diagnosis of IBSwas based on Rome III criteria.Results: The overall prevalence of IBS was 39.3%, but the majority (77.3%) had nobasic awareness of IBS. In our study, anxiety and depression (χ2 = 6.817; odds ratio[OR] = 1.910; 95% confidence interval [CI] = 1.172, 3.113; P = 0.011) had a signif-icant relationship with IBS and IBS had a significant (P < 0.001) relationship withfood intolerance (χ2 = 8.737; OR = 2.130; 95% CI = 1.284, 3.531), chest pain(χ2 = 7.482; OR = 2.035; 95% CI = 1.218, 3.401), and insomnia (χ2 = 19.320;OR = 2.907; 95% CI = 1.794, 4.709). In our dietary data, the intake patterns of vege-tables (P = 0.000), fast food (P = 0.000), and tea–coffee (P = 0.003) showed astrong significant association with IBS. On the other hand, monthly household income(P = 0.154) and body mass index (BMI) (P = 0.138) showed no significant associa-tion with IBS. Among our study subjects, IBS-constipation (54.2%) was more com-mon than IBS-diarrhea (27.1%) and IBS-mixed (18.6%). Moreover, among the 118IBS respondents, 67.8% had a headache with increased flatulence (95.8%) as the mostcommon IBS-related complication.Conclusion: IBS is common in university students of Bangladesh and is associatedwith anxiety, depression, and particular dietary patterns.

Arafat hassan razon

Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. So, new treatment modalities are needed. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide a productive treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa.

Dr. salman ahmed

Plant secondary metabolites refer to various chemical compounds that plants produce. Still, they are not directly involved in essential growth processes like primary metabolites (such as sugars, amino acids, and lipids). The term "secondary metabolite" has generated controversy, as it implies these compounds are of minor importance to plants. "Special metabolites" may be a more suitable term. These metabolites protect plants from both abiotic and biotic stress. The vast diversity of plant secondary metabolites showcases plants' incredible adaptability and versatility, providing an arsenal of chemical tools to defend against herbivores, protect from pathogens, attract pollinators and seed dispersers, adaptability and thrive in environmental interactions. Plants can, therefore, survive under less-than-ideal conditions. The profound impact of plant secondary metabolites highlights the intricate relationship between plants and humanity, opening doors to innovative applications with far-reaching implications.

Dr. salman ahmed

The inculcation of Islamic religious values ??is an effort to shape the character of students to achieve a degree as a human being who is in accordance with norms, culture and religion. This research describes the process of internalization and the method of cultivating Islamic religious values ??in an unusual situation, namely in the era of the Covid-19 pandemic. In this study, researchers used a qualitative approach, a type of case study with interview and observation data collection techniques. The results of this study indicate that the implementation of student learning in a pandemic situation is carried out in two ways, namely (1) online and (2) offline. The values ??instilled in students include (a) worship, (b) faith and (c) morals. Meanwhile, the methods used by teachers in the process of inculcating Islamic religious values ??during the pandemic were practice methods, guidance methods, and memorization methods. Penanaman nilai-nilai agama Islam merupakan sebuah upaya dalam membentuk karakter siswa untuk mencapai derajat sebagai manusia yang sesuai norma, budaya serta agama. penelitian ini mendeskripsikan proses internalisasi hingga metode penanaman nilai-nilai agama Islam di situasi yang tidak biasa yakni di era pandemi covid-19. Dalam penelitian ini, peneliti menggunakan pendekatan kualitatif, jenis studi kasus dengan teknik pengumpulan data wawancara dan observasi. Hasil dari penelitian ini menunjukkan bahwa pelaksanaan pembelajaran siswa dalam situasi pandemi dilakukan dengan dua cara yakni (1) daring dan (2) luring. Nilai-nilai yang ditanamkan kepada siswa meliputi (a) ibadah, (b) keimanan dan (c) akhlak. Sedangkan metode-metode yang digunakan guru dalam proses penanaman nilai-nilai agama Islam selama pandemi adalah metode praktik, metode bimbingan, dan metode hafalan.

Educare: journal of primary education

Background: Non-syndromic combined pituitary hormone deficiency (CPHD) occurs due to defects in transcription factors that govern early pituitary development and the specification of hormone-producing cells. The most common mutations are in the Prophet of Pit-1 (ProP1) gene. This work aims to (1) report findings of genetic analyses of Tunisian patients with non-syndromic CPHD and (2) describe their phenotype patterns and their evolution through life. Methods: Fifteen patients from twelve unrelated families with variable clinical phenotypes were included after excluding autoimmune and acquired forms of non-syndromic CPHD. Detailed pedigree charts and auxological, hormonal, radiological, and therapeutic details were recorded. Sanger sequencing was performed, and sequences were analyzed with a specific focus on coding and splice site regions of the ProP1 gene. Retained variants were classified using several in silico pathogenicity prediction tools and the VarSome platform. Results: We identified the common p.Arg73Cys mutation in seven patients from four unrelated pedigrees. We found a novel homozygous mutation (c.340C>T) in one sporadic case. This mutation generates a truncated ProP1 protein, predicted to be non-functional, lacking the last 112 codons (p.(Gln114Ter)). We confirmed by polymerase chain reaction (PCR) the absence of large exon deletions or insertions in the remaining sporadic patients (7/8). Conclusions: We report two mutations {one newly identified [p.(Gln114Ter)] and one previously reported (p.Arg73Cys)} in five unrelated Tunisian families with non-syndromic CPHD. This work is of clinical importance as it reports the high frequency of the p.Arg73Cys mutation in Tunisian CPHD families. Our study also illuminated the involvement of novel gene(s) in the emergence of non-syndromic CPHD.

Mariam moalla

Developmental venous anomalies (DVAs) are congenital vascular malformations often found incidentally on neuroimaging. This case report describes a 37-year-old female with chronic headaches and an incidentally discovered DVA in the left frontal lobe. Magnetic resonance imaging (MRI) revealed a classic "caput medusae" pattern without hemorrhage or associated cavernous malformation. This case highlights the importance of recognizing DVAs as incidental findings, differentiating them from other causes of chronic headaches, and understanding the significance of associated imaging findings.

Karishma

In this paper, an approach for formulation of generalized field data based model for cylinder head moulding operation. The aim of field data based modeling for cylinder head moulding operation is to improve the output by correcting or modifying the inputs. The goal of the research is to reduce human energy input required while performing cylinder head moulding operation. With the reduction in human energy input, automatically, the productivity of the process will also increase. The study identifies important ergonomic and other work environment related parameters which affect productivity. The identified parameters are properties of sand, physical dimensions of tools, energy outflow of workers, anthropometric data of the workers, working conditions like relative humidity, ambient temperature. Out of all the variables, responses and causes are identified. After dimensional analysis relationship between the dependent and independent parameters, a mathematical model is established having a relationship between output parameters and input. To get the optimized values model is optimized using the optimization technique. Sensitivity analysis is a tool which can be used to find out the effect of input one parameter over the other. The model will be useful for an industrialist to select optimized inputs so as to get targeted responses.

Rahul bachute

A leader is a person, who influences his followers. The role of leader is often associated with managerial concepts, where a leader leads a team of employees, guides them, motivates them and influences them, in such way that the organisational productivity is honed up. A lot emphasis is on the style of leadership, exhibited by the manager, in honing the productivity of the organisation. According to (Hanvey, 2002; Janus, Kopechanski, Cameron, & Hughes, 2007; Morinaka, 2012; Reio & Fornes, 2011), most parents have dreams and hopes about their children and their lives. But, parents of children with special needs, though have, such dreams and hopes, have a harder time meeting these goals. According to Hanvey (2002), these parents need to devote more time and responsibilities, when it comes to raising a child with special needs, like caring for the child’s physical requirements due to his/ her disability, helping them with their physical and social needs and also help them in developing relationships with the others, so that they get a feeling of belongingness. Families with children having special needs undergo a higher level of stress (Gottfried & McGene, 2013). Families that have children with special needs, go through enormous stress levels, at times even financially stressed are they … (Hanvey, 2002; Moriwaka, 2012). But, Current study focusses on the effective leadership role played by a mother during the Pandemic, which is helping the kids, especially the children with special needs in combating the stress, that they are undergoing. A case of a child, diagnosed with autism(a serious behavioural disorder among young children that now occurs at epidemic rates in developing countries like India), since she turned two and how her mother has been helping her adapt to the new normal of staying home for all her activities and coping up with the increased stress levels.

Nandini

This Research Paper elucidates the challenges faced by teachers while teaching learners with learning disability. This has been conducted as a research study by the Research Scholar which explores multifaceted aspects of ‘challenges based on the responses given by the participants in the interview. It is a study designed to identify multifaceted dimensions of challenges faced by teachers while teaching learning disabled children. The research study analyzes the impact of challenges on teachers and how they are overcoming these challenges. This descriptive study was carried out as qualitative research under an Indian scenario based on Primary data available on the subject. The research enquiry focused on several research questions: What is the teacher’s understanding of learning disability? What challenges do remedial teachers face while teaching children with learning disability and how do they overcome them? What are the teaching approaches and methodology used to teach children with learning disability? The study will try to highlight the challenges faced by teachers to address them in front of the school administration. The challenges faced by teachers while teaching learning disabled children, i.e., ‘Teaching material and Curriculum structure’, ‘Behavioural issues’, ‘Lack of time’, ‘Parental expectations and Parental issues’, ‘Motivation’, ‘Self-esteem’ and ‘Emotional issues. The methods used to overcome these challenges were pointed out and analyses. Each teacher was using their own methods to tackle these challenges but some methods were used generally and an individual tailored method were developed and used according to respective learners.

Hashir ahammed a v