Evidence demonstrates that inappropriate drug disposal creates a significant risk to global environmental safety. Study participants' knowledge, attitude and practice regarding the disposal of unwanted and expired medications were assessed. The study was carried out at Sebha city, in southwestern Libya, from October 2021 to April 2022. A self-administered questionnaire designed explicitly to be completed by a respondent without an interviewer's assistance was used. Out of 650, only 500 completed questionnaires was returned. The majority of the respondents admitted they have at least one medication stored at home (71.6%). Keeping expired drugs were reported by 28.2% of the respondents compared with unused medications in their house (51.2%). Almost half of the respondents (47.4%) declared that their medication were taking from the private pharmacies. “I’ll need it in the future” (48.8%), "Medicines change" (37.2%) and "Symptoms improve and recover" (32.6%) were the top three explanations given by participants. The majority of drugs reported were antibiotics (41.0%). This is followed by antipyretic and analgesic drugs, which were used by 29.8% and 27.8% of respondents, respectively. 52.2% of the respondents agreed that disposing of medicines in the garbage is the most appropriate method. Concordantly, the majority of them indicated they discarded unused or expired medicines whether they were solid (82.6%), liquid (58.4%), or semisolid (79.6%). The majority of participants indicated they were aware of the negative impact of drug waste on the environment (80.6%). More than three quarters of the participants said they had never been given instructions on how to properly dispose of medications and 60.8% thought a medical team would be the best source of knowledge. Despite acknowledging being aware of the harmful effects on the environment, the majority of participants admitted to keeping unneeded pharmaceuticals in their homes and throwing them out in the trash. The government should support the pharmacists' role in educating the public about how to properly dispose of their medications and establish the Return Unwanted Medicines Project in order to raise awareness and create cost-effective medication waste management programs.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: The first wave of the COVID-19 pandemic was associated with significant morbidity and mortality among healthcare workers worldwide. The present study aimed to assess the knowledge, attitudes, and practices of healthcare workers toward COVID-19 at Ataq General Hospital, and three other hospitals and health centers in Shabwah Governorate, Yemen. Materials and Methods: From January 1, 2022, to February 28, 2022, a cross-sectional survey of healthcare workers was conducted in the city of Ataq, Shabwah Governorate at the following hospitals: Ataq General Hospital, Al Shefa’a Hospital, Al Aafiah Hospital, and COVID-19 Isolation Center. Results: A total of 107 healthcare workers completed the survey. Their mean age was 28.17 ± 7.73 years, 79 (73.8%) of them were male and 28 (26.2%) were female. The overall knowledge was good, with a score of 19 out of 21; however, most participants were unaware of some of the extra-respiratory symptoms of the disease, such as diarrhea and confusion, and about 57% of them were unaware that eating or interacting with wild animals may contribute to the infection with the COVID-19 virus. Attitude analysis of the participants revealed that about half of those surveyed do not believe that Yemen can contain COVID-19. In general, the practice of the participants was good. Conclusion: Although the overall knowledge score in this study was good, most respondents could not recognize some of the extrapulmonary manifestations of COVID-19 and were unaware of the possibility of transmission of the disease from wild animals. In addition, about half of those surveyed do not believe that Yemen can contain COVID-19

Karishma

Moringa oleifera, a very important healthful plant, is one amongst the foremost wide cultivated species of the family Moringaceae. It's extremely valued from past as a result of its large healthful properties. Moringa oleifera, native to India, grows within the tropical and climatic zone regions of the globe. It's commonly called drumstick tree or horseradish tree. Moringa will face up to each severe drought and gentle frost conditions and, therefore wide, cultivated across the globe. With its high alimentary values, each part of the tree is appropriate for either nutritional or commercial purposes. The leaves are rich in minerals, vitamins and alternative essential phytochemicals. Extracts from the leaves are useful in treatment of anemia, enhance breast milk in wet mothers. It's used as a potential antioxidant, anti-cancer, anti-inflammatory, anti-diabetic and antimicrobial agent. Thus, this study was aim to investigate the phytoconstituents from ethanolic and aqueous extracts of the Moringa oleifera cultivated in Libya and to assess its anti-bacterial and anti-diabetics activity. The phytochemical investigations of these extracts of Moringa oleifera revealed the presence of alkaloids, carbohydrates, flavonoids, saponins, steroids, tannins and phenolic compounds. The antibacterial activity of cold and hot extraction of methanolic and water extracts of Moringa oleifera by using the well diffusion method were assessed. Results revealed that there was a profound antibacterial activity of the studied Moringa oleifera against representatives of Gram-positive bacteria. After in vitro evaluation of anti-hyperglycemic properties of the ethanolic extract of Moringa oleifera by testing its capacity to inhibit α-amylase activity, the methanolic extract exhibited inhibitory effect on the α-amylase enzyme.

Mediterranean journal of pharmacy and pharmaceutical sciences

Purpose of this study is examining the cause of stress among selected private banking employees. Stratified sampling method was used to carry out the data collection. For this employee of various private banks were chosen. A questionnaire with 12 items with dichotomous (Yes-1, NO-2) were developed and tested for reliability and prior to the distribution of questionnaire. 253 respondents were selected from various private banks in Mysore district, Karnataka state India. The survey questionnaire was sent via email, requesting to complete it. The questionnaire includes 11 demographic information’s and statements to measure. Chi-Square analysis was carried out to examine the cause of stress among employee using SPSS21. We found that designations have significant influence on employee and The other factors of do not have any significant influence on employee. Therefore we concluded that in private banks demographic variable such as designation creates stress in all aspects. Future research should consider a larger sample from leading sectors where job natures are similar. Analysis should be more rigorous, where Amos could be used for analysis.

Dr manjunatha m k

Abstract: Objective: To evaluate the Antiparkinson activity of Allium sativum in Haloperidol induced Parkinson‟s disease in mice. Method: Parkinson‟s disease was induced by administering haloperidol (2.0 mg/kg i.p.) Daily for a week. The mice were divided into 5 group (n=6). Group II received haloperidol (2mg/kg body weight).Group III received combination of levodopa and carbidopa (100mg+ 10mg/kg by i.p along with haloperidol) and Group IV and V received Allium sativum extract (200 and 400mg/kg by p.o), respectively for 7 days along with haloperidol. To evaluate the antiparkinson effect of Allium sativum, catalepsy bar test, rotarod test, hang test and horizontal bar test were used. One way ANOVA was used to test statistical significance followed by Bonferroni multiple comparison tests .Results: Allium sativum extract (200 and 400mg/kg by p.o) was found to decrease the duration of catalepsy significantly (P<0.001) in catalepsy bar test as compared to haloperidol group, and significantly increases (P<0.001) fall off time in, rotarod test, hang test and horizontal bar test respectively as compared to haloperidol group. Conclusion: The result of the present study conclusively shows the Antiparkinson‟s activity of Allium sativum in haloperidol induced Parkinson‟s disease in mice.

Zeenath banu

Background Covid-19 pandemic has hit many countries and put the majority of the public health system to test globally. Mandatory use of face mask was among policies set by the government to contain the spread of the novel disease. But citizens’ attitudes and compliance with these policies are important in controlling the pandemic. We assessed gender-based compliance to Covid-19 protocol (use of face mask) in Jos South, Plateau State, Nigeria. Methods Perception regarding Covid-19 and the use of face masks were assessed among participants using a questionnaire-based survey. In a cross-sectional study, ninety (n=90) questionnaires were administered to willing participants directly. A Chi-square test was used to determine the descriptive analysis of all responses, P-values <0.05 were considered statistically significant. Result Out of 90 participants, 55.6% (50/90) were male and 44.4%(40/90) were female. Forty-two (84%) males deny the existence of the pandemic while in females, 14 (35%) deny that Covid-19 exist. Thirty-seven (74%) of the male respondents do not comply with to use of the face mask and use a single face mask multiple times without decontamination. In females, 28 (70%) comply with the use of the face mask. Unlike the men, 20 (50%) of the females always decontaminate the face mask. The middle-aged adult (26-45 years) uses the face mask more than the young (18-25 years). There was a significant association of gender in relation to the perception of Covid-19 and the use of facemask (p< 0.05). Conclusion Male respondents showed an irresponsible attitude complying to Covid-19 protocol than the females, therefore, enlisting them as a risk factor for the continued spread of the virus. We recommend that public health awareness and campaigns should focus and employ greater influence on men and young adults in their compliance with the preventive protocols.

Bitrus inuwa

Cleome brachycarpa Vahl . and Cleome viscosa L. were evaluated for anti-emetic activity in the copper sulfate-induced chick emesis model. Emesis was induced by copper sulfate (50 mg/kg), and the methanolic extracts of leaves were tested orally at a dose of 150 mg/kg. Chlorpromazine (150mg/kg orally) was used as standard anti-emetic drug. The anti-emetic activity was determined by calculating the mean decrease in the number of retching as compared with the control. Cleome brachycarpa and Cleome viscosa showed comparable anti-emetic activity with chlorpromazine.Cleome brachycarpa Vahl ., and Cleome viscosa L., leaves extract in a dose of 150 mg/kg body weight., reduced the numbers of retches by 57.57% and 43.06%. Cleome brachycarpa significantly (**P<0.005) reduced the number of retches. The group of chicks treated with chlorpromazine had 45 retches compared to the 71 retches of the control group, thus chlorpromazine reduced the retches by 36.99%. From the results, it is clear that Cleome brachycarpa Vahl. and Cleome viscosa L. leaves extracts have antiemetic potential and are comparable with standard chlorpromazine. Although the result is significant the mode of action is not known. Antiemetic activity by using copper sulfate proposed 5-HT3, 5-HT4, or NK1 receptor antagonism. Therefore, the extracts effectively prevented its effect and had a peripheral anti-emetic action. As mentioned earlier, triterpenoids such as brachycarpone, deacetoxybrachycarpone, cabralealactone and ursolic acid are reported from Cleome brachycarpa6, whereas flavonoids are reported from Cleome viscosa. Flavonoids and triterpenoids possess anti-emetic properties18. So, if flavonoids and triterpenoids are present in the studied extracts, the observed anti-emetic effects may be due to flavonoids and triterpenoids. The present study is on the preliminary level, and further investigation is required to confirm the anti-emetic effect of Cleome brachycarpa Vahl ., and Cleome viscosa L. leaves and determine the compounds responsible for this activity with their possible mode of action.

Dr. salman ahmed

Background: Water distribution systems within healthcare facilities are complex ecosystems that can harbor opportunistic pathogens, posing a significant risk to patient safety. Ensuring the microbiological quality of water requires rigorous monitoring and a deep understanding of the entire system, from source to point-of-use. This study undertakes a comprehensive statistical analysis of microbiological data from a healthcare facility’s water treatment and distribution network to identify contamination hotspots, evaluate the efficacy of critical treatment barriers, and map potential contamination pathways. Methods: This retrospective case study analyzed heterotrophic plate count (HPC) data collected from 29 distinct sampling points throughout a healthcare facility’s water system. The points represented various stages, including municipal source water, intermediate treatment steps (softening, ultrafiltration, reverse osmosis), storage tanks, and multiple points-of-use. Non-parametric statistical methods were employed due to the non-normal distribution of microbial data. A Kruskal-Wallis test with Dunn's post-hoc analysis was used to compare microbial loads across all sampling points. A focused Mann-Whitney U test was performed to assess the performance of the ultrafiltration (UF) unit. Results: The analysis revealed significant variability in microbiological quality throughout the system (Kruskal-Wallis, p<0.0001). One point-of-use and a pre-UF exhibited high median microbial counts and extreme variability, indicating chronic contamination and potential biofilm proliferation. Critically, the ultrafiltration unit failed to demonstrate a statistically significant reduction in microbial load between the pre-filter. Conclusion: The data reveals variability in microbiological levels across the water system, suggesting that the ultrafiltration barrier's performance is a significant factor influencing downstream water quality. The data points to systemic issues, likely involving widespread biofilm, that compromise water quality at the points-of-use.

Mostafa eissa

Background and Objectives: Despite the controversies that prevail regarding the efficacy of episiotomy, it is still practiced widely around the world in various degrees of prevalence. This study aimed to identify and analyze the prevalence, clinical profile, and complications of episiotomy performed on women who delivered at the Asha’ab Obstetric Emergency Center. Patients and Methods: This was a cross-sectional study that involved women who had undergone vaginal delivery at the Asha’ab Obstetric Emergency Center, in Aden city, Yemen, between October 1, 2021, and March 31, 2022. Permission to conduct the study was obtained from the center’s administrative office. Results: During the study period, 858 women delivered vaginally at our center. Out of these, 443 women had had an episiotomy, representing an episiotomy prevalence of approximately 51.6%. These 443 women were enrolled in this study. The episiotomy was more common among primigravida women (n=362, 81.7%), followed by multiparous women (n=42, 9.5%). The most commonly associated medical disorder was anemia (n=167, 37.7%), followed by hypertension (n=33, 7.4%). Perineal pain (n=51, 11.5%) was the most frequently reported post-episiotomy complication, followed by perineal discomfort (n=32, 7.2%), wound infection (n=27, 6.1%), perineal bleeding (n=18, 4.1), difficulty in walking (n=9, 2.0%), wound dehiscence (n=3, 0.7%), and difficulty in defecation (n=1, 0.2%). Conclusion: The prevalence of episiotomy among women who gave birth at the Asha’ab Obstetric Emergency Center, in Aden city, Yemen, was higher than the World Health Organization recommendation, which is around 10% or less with acceptable obstetric evidence indicating the need. Further prospective large-scale studies are recommended to confirm the findings of this study.

Karishma

In addition to predatory journals and publishers, researchers now need to be wary of predatory conferences as well with the checklist given here to really check yourself.Because the predatory journals and publishers make target to the new researchers there must be need of that type of articles

Dr.ved nath jha

Background: Information on Bleomycin pulmonary toxicity (BPT) in Qatar is scarce. The aim of this study was to estimate the prevalence of BPT and to describe its clinical significance and outcome in germ cell tumor (GCT) patients who received bleomycin-containing regimens.Methods: This retrospective cross-sectional study was conducted at the National Center for Cancer Care and Research. It included all patients diagnosed with GCT and treated with a bleomycin-containing regimen between January 2002 and December 2008 Results: We identified fourteen patients with GCT who received bleomycin containing regimen. Four of them (28.5%) had developed BPT, and they were males with mean age of 39.3±8.3 years (range: 25-46 years). The calculated creatinine clearance before treatment was normal in the 4 cases. Evaluation of the chest computed tomography scan before starting bleomycin containing regimens revealed that none of our patients had pre-existing parenchymal lung disease. The mean cumulative bleomycin dose was 187.5± 153.7 U, while the mean time to onset of BPT was 3.5±2.1 months. Once the diagnosis of BPT was established, bleomycin was discontinued in the four patients and short courses of dexamethasone were administered. Two patients (50%) died, while one patient survived with a fibrosis sequel, and the fourth patient recovered without a fibrosis sequel. Conclusion: BPT is one of the life-threatening side effects of this drug that every doctor should be aware of when treating GCT, therefore, a high index of suspicious is needed for early recognition of BPTs.

Karishma

The decision of the government of India to allow foreign direct investment in higher education is based on a consultation paper prepared by the commerce ministry, which is marked by arguments, perverse logic and forced conclusions. FDI in any field does not have an attached objective of fulfilling social agenda of the welfare state. It is guided by profit and market. This would result in commoditization of education. As per past most foreign institutes invest in technical courses which market needs rather than in quality education and research which is important for creating and developing human resource. There is a shortage of funds in higher education sector. Here are not many ways in which this investment in this sector can be increased in this sector domestically. Since a large number of students go abroad for their higher education, it is sensible to allow foreign universities to set up their campuses here, in India. This would help in arresting the outflow of monetary and human capital. Further, foreign higher educational institutes would create competition with the local institutes making them internationally competitive this article examines the issues and financial compulsions, presented in the consultation paper

Dr gedam kamalakar

Family businesses must harness the full potential of their human resources and maintain employee loyalty to achieve the companies’ objectives effectively. This study examines the influence of transformational leadership on employee commitment through work-life balance and workplace social support. The research was conducted from August to December 2023 using an online questionnaire distributed to employees in a family firm in Medan, Indonesia. The data were then analyzed using PLS-SEM. The results show that transformational leadership significantly effects employee commitment, work-life balance, and workplace social support. However, although workplace social support mediates the relationship between transformational leadership and employee commitment, work-life balance fails to do so. It was also found that work-life balance has no direct influence on employee commitment. Using an IPMA analysis, this study highlights the importance of transformational leadership and workplace social support in the family business environment. Transformational leadership has also been shown to have the best performance and effect on employee commitment. Managers should prioritize these aspects to reduce employees’ stress levels, improve psychological well-being, and increase job satisfaction, leading to a more committed, high-performance workforce.

L

Determinations of competency in adult criminal court have an extensive history, both procedurally and conceptually. Unlike criminal court, however, juvenile courts were designed for rehabilitation, rather than punishment, and, historically, the issue of competency was not often raised. Recently, however, as stakes for youth in juvenile court have begun to parallel those of defendants in criminal court, youths’ competence has become an important issue. The purpose of this study was to investigate whether defendants’ age and maturity affect judges’ ratings of juveniles’ adjudicative competence in juvenile and criminal court. Three hundred forty two criminal and juvenile court judges reviewed one forensic psychological report about a hypothetical defendant; only the age (12-17) and maturity level (less mature; more mature) of the defendant varied across reports. The judges then rated the juvenile’s adjudicative competence in both juvenile and criminal court, provided ratings of the individual competence components, rated their confidence in their decision, and rated the importance of various characteristics of the juvenile to their decisions. Judges also provided demographic information. Results revealed a main effect for age, with older juveniles generally deemed more competent, and a main effect for maturity, with more mature juveniles generally deemed more competent. There was no interaction between age and maturity. Results suggest that age and maturity play major roles in judicial determinations of juvenile competency

John dolores

Texas bays and estuaries experience salinity fluctuations (e.g., droughts, reduced freshwater inflows and hurricanes) caused by natural weather and climate change. This could have impacts on red drum Sciaenops ocellatus (Linnaeus) early life stages beacause red drum spend their early life stage at the shallow bays and estuarine waters of Texas Bay. The purpose of the present study is to evaluate the impact of high salinity concentrations on the survival, growth and development of red drum eggs and larvae. Red drum brood stocks were collected from wild stocks throughout the lower Texas coast and were held in hatchery tanks (13,250 L) until spawning. The water quality conditions were maintained at a salinity of 38ppt and seawater temperature of 25°C. The red drum eggs were hatched at a wide range of salinity treatments (28-48ppt). Egg hatch-out rates and larvae growth were reduced at the lowest (28ppt) and highest (48ppt) salinity treatments. Hypersalinity (≥ 40ppt) and a temperature of 25ºC affected the hatching success of red drum eggs. The percentage of egg hatching success and length of larvae were reduced in both lower (28ppt) and/or hypersalinity (48ppt). This study shows that red drum eggs can hatch within a wide range of salinities with best hatch-out and growth rates occurring between 33 – 43ppt. It also suggests that climate change that produces global warming can keep the increasing environmental salinity of the Texas bay which might have an impact on the development of the early stages of the red drum in their natural environment.

Irma kesaulya

In the present study, the bacterium Achromobacter xylosoxidans was isolated from tannery effluent sludge sample in Dindugal, Tamil Nadu, India and screened for its bio-control efficacy against selected plant pathogens viz., Alternaria solani, Curvularia lunata and Fusarium oxysporum under in vitro. It was observed that maximum percent inhibition of mycelial growth of C. lunata (95%), followed by A. solani (85%) and F. oxysporum (80%). An attempt was also made for testing its plant growth promoting traits such as production of Indole acetic acid (IAA), phosphate solubilization efficacy, Hydrogen cyanide (HCN), ammonia and catalase production. Significant amount of plant growth promoting traits were noticed. Further studies on mechanism of bio-control against plant pathogens and plant growth promoting activities of Achromobacter xylosoxidans need to be conformed under in-vivo condition.

Dr. saranya devi k

Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) is used worldwide to test and trace the spread of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). “Extraction-less” or “direct” real time–reverse transcription polymerase chain reaction (RT-PCR) is a transparent and accessible qualitative method for SARS-CoV-2 detection from nasopharyngeal or oral pharyngeal samples with the potential to generate actionable data more quickly, at a lower cost, and with fewer experimental resources than full RT-qPCR. This study engaged 10 global testing sites, including laboratories currently experiencing testing limitations due to reagent or equipment shortages, in an international interlaboratory ring trial. Participating laboratories were provided a common protocol, common reagents, aliquots of identical pooled clinical samples, and purified nucleic acids and used their existing in-house equipment. We observed 100% concordance across laboratories in the correct identification of all positive and negative samples, with highly similar cycle threshold values. The test also performed well when applied to locally collected patient nasopharyngeal samples, provided the viral transport media did not contain charcoal or guanidine, both of which appeared to potently inhibit the RT-PCR reaction. Our results suggest that direct RT-PCR assay methods can be clearly translated across sites utilizing readily available equipment and expertise and are thus a feasible option for more efficient COVID-19 coronavirus disease testing as demanded by the continuing pandemic.

Bitrus inuwa

Foreign Direct Investment as a strategic element of funding is required in every develop & developing country for achieving the financial growth & reforms and continue the pace of development and progress of the economy. FDI inflows are long term in nature which causes source of non debt finance, as well as bring modern & innovative technology in country by creating international network. In this paper, author attempted to discover how FDI is crucially important economic catalyst of Indian monetary progress by stimulating domestic investment. The essential purpose of this paper is to investigate the effect of FDI on fiscal growth by analyzing most important sector i.e. Banking Sector. And this sector is rapidly expanding with several challenges, raise due to competition by the new players in this ever growing sector. Whereas new initiatives of government like demonetization & Digital India, leads toward need of modern technologies & polices in banking sector which could be only possible by FDI in banking sector.

Anshuman vijay magar

Abstract- The role of support vector machine in the evaluation of English teaching effect is very important, but there is a problem of inaccurate evaluation of results. The traditional English teaching mode cannot solve the accuracy and efficiency of the effect evaluation of students' English teaching and cannot meet the requirements of English teaching effect evaluation. Therefore, this paper proposes a neural network algorithm to innovate and optimize the analysis of support vector machines. Firstly, the relevant theories are used to construct a multi-index English teaching effect evaluation system with teachers and students as the main body, and the indicators are divided according to the data requirements of English teaching effect evaluation indicators to reduce the support vector machine in the interfering factor. Then, the neural network algorithm is used to solve the optimal solution of kernel function parameters and regularization parameters of the support vector machine, and the support vector machine scheme is formed, and the support vector machine results are carried out Comprehensive analysis. MATLAB simulation shows that the evaluation accuracy of the English teaching effect of the neural network algorithm and the support vector machine under certain evaluation criteria Optimal, short evaluation time.

Lokesh n s

The present study was designed to investigate the in-vitro thrombolytic activity of various extracts of seeds of Salvia hispanica by Clot lysis method. In this study, Streptokinase was used as a positive control and the human blood was taken as test sample. The mean % of clot lysis for streptokinase was found to be 66.8%. Similarly the methanolic, ethanolic, aqueous and acetonic extracts of salvia hispanica exerted 48.5%, 35.8%, 33.3%, 27.7% lysis of the blood clot in thrombolytic activity test respectively. From our findings it was observed that all the extracts of Salvia hispanica revealed remarkable thrombolytic activity

Zeenath banu