The beneficial medicinal effects of plant materials typically result from the secondary products present in the plant although, it is usually not attributed to a single compound but a combination of the metabolites. The medicinal actions of plants are unique to a particular plant species or group, consistent with the concept that the combination of secondary products in a particular plant is taxonomically distinct.The screening of plants usually involves several approach; ethno botanical approach is one of the common methods that are employed in choosing the plant for pharmacological study. In the present review paper, antimicrobial properties of various medicinal plants were reviewed. The present review deals with the antibacterial activity of various medicinal plants.

Tapan kumar mahato

Macrotyloma uniflorum (Lam.) Verdc. (Papilionaceae) is commonly known as Horse gram and Kulthi. The seeds are reported as anthelmintic, diaphoretic, diuretic and emmenagogue. It is also useful for asthma, bronchitis, and urolithiasis. The present study evaluated the analgesic, anti-inflammatory and diuretic effects of the methanol extract of Macrotyloma uniflorum seeds in 200 and 400mg/kg doses. Significant results were obtained in all activities.

Dr. salman ahmed

Uric acid has increasingly been associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. Diabetic patients who are hyperuricemic have a risk of developing diabetic complications. Pathogenesis of uric acid may decrease nitric oxide bioavailability in vascular smooth muscle, endothelial cells and direct scavenging of nitric oxide by uric acid. A decrease in endothelial nitric oxide production by uric acid has also been associated with endothelial dysfunction and insulin resistance. This study aims is to determine the relationship between uric acid and glucose levels in patients with type 2 diabetes mellitus. The study included 161 Libyan patients (67 males and 94 females) diagnosed with type 2 diabetes mellitus. Both levels of serum uric acid and hemoglobin A1c (HbA1c) were determined. The patients were divided into two groups. The controllable diabetic group with HbA1c of less than 06.0% and the uncontrollable diabetic group with HbA1c of more than 06.0%. Patients who are suffering from type 2 diabetes mellitus without complications were included whereas patients with smoking, alcoholism, nephrotic disease, malignancy, hepatitis, and renal failure or kidney disease were excluded. The mean and standard deviation of uric acid, HbA1c and Pearson correlation coefficient test were considered. In the controllable diabetic group, serum uric acid mean was found to be 4.807 ± 1.39 and HbA1c was found to be 5.032 ± 1.39. In the uncontrollable diabetic group, serum uric acid was 4.897 ± 1.66 and HbA1c was 8.396 ± 1.65. Uric acid level has significantly been correlated with HBA1C in controlled and uncontrolled diabetic patients (p < 0.05). In addition, the uric acid level was found to be higher in uncontrolled diabetic group than that in the controlled group (p < 0.05). A possible relationship between serum uric acid and incidence of type 2 diabetes mellitus was noted. Thus, uric acid can be used as a potential biomarker to indicate impaired glucose metabolism.

Mediterranean journal of pharmacy and pharmaceutical sciences

в статье анализируются основные причины и критерии иностранных инвестиций, основная роль внедрения инновационных технологий в рыночную экономику. А также роль иностранных инвестиций в модернизацию экономики Узбекистана.

Ikboljon odashev mashrabjonovich

A 33-year-old young male patient with a history of uncontrolled hypertension was referred to my clinic due to a 2-week fever, generalized body aches, shortness of breath, and easy fatigue. Clinical examination showed a toxic dyspneic patient, but conscious and well-oriented. His blood pressure was 170/100 mm Hg, pulse 90 beat/min, respiratory rate 15/min, and the temperature was 38.6°C. Cardiac examination showed a harsh systolic murmur at the mitral area radiating to the axilla. Abdomen examination revealed moderate splenomegaly and mild hepatomegaly. The rest of the examination was unremarkable.

Karishma

This study explores the influence of education, length of service, professionalism, and ethics on the professional values of public relations practitioners in Malaysia. A total of 427 questionnaires were distributed to public relations practitioners in Malaysia, and 322 questionnaires were returned. The study included 61% female respondents, and 39% male respondents. The study analyzed and identified the influence of professionalism and ethics on professional values of public relations practitioners. Additionally, the study examined whether education and experience influence professional values through professionalism, and code of ethics. Six hypotheses were tested to answer the research questions. The results from this study fully supported the hypotheses indicating that professionalism and ethics had an influence on professional values of public relations practitioners. The results also showed that education influenced both professionalism and ethics, and length of service influenced both professionalism and ethical practice.

Mohammed fadel arandas

Concrete is a material which is used in construction. Weight of concrete plays a major role in the construction industry. If the weight of the concrete is increased, it will pose more structural problems on the later date of construction. It also increases the cost of construction, without any specific benefit. So if lightweight concrete is used, it not only reduces cost of construction, but also not poses any structural problems unnecessarily. Light weight concrete also aids workers in smooth handling of materials. In this study, vermiculite in the form of exfoliated form is used to replace partially natural sand. By this action dead weight of the structure is reduced. Once the dead weight of structure is reduced, it in turn reduces cost of construction. In this study three mixes were casted with the cement content of 383 kg/m3 in M20 concrete and the water cement ratio of 0.45 is chosen. Vermiculite at 10%, 20% and 30% are choosing to partially replace the natural sand. The Tests conducted on concrete for evaluating mechanical properties include compressive strength and split tensile strength. For evaluating durability properties, tests like acid resistance, sulphate resistance, chlorine penetration and water absorption.

Kiran kumar narasimhan

The cross line movement according to the two labor and products is the thing to take care of in the present worldwide economy. Worldwide exchange labor and products has for some time been a standard, for different advantages that gather from it. There have been numerous respective and multilateral arrangements comparable to cross line exchange dealings. The development of administrations area that decidedly influences the everyday daily routine and guidelines of experiencing or personal satisfaction. The World Trade Organization (WTO), of which in excess of 156 nations are individuals, has an understanding according to global administrations exchange. The General Agreement on Trade in Services (GATS) is the WTO's arrangement that administers exchange 12 sorts of administrations, including 'instruction administrations'. One of the basic inquiries or issues in such manner would be corresponding to the sort of college to be permitted to set up its grounds or branch or in any case offer training administrations. This paper would endeavor to give some potential experiences into this issue. Internationalization and globalization are the two Global ideas terms conversely utilized as far as higher education. Most impressively, the test to set up colleges will come from the worldwide monsters of the interchanges, data innovation and mixed media ventures worldwide suppliers, packed with capital, ready to get to remarkable global researchers and educators, talented in giving in situ understudy support at the same time in numerous nations, and equipped for expediting proficient accreditation and acknowledgment all throughout the planet. Quality in the subsequent 'worldwide virtual colleges' will be high, normalization will make cost structures that are powerfully serious, brand acknowledgment will be acquired, maybe by accepting one of the incomparable Ivy League organizations as an accomplice, or on the other hand by moving into advanced education a prevailing brand from the correspondences or processing ventures.

Dr gedam kamalakar

With 450 questionnaires, the authors used SPSS software to analyze and found that the researched factors all had a positive impact on the development of community tourism services in Ha Giang province. In particular, the degree of influence on the development of CBT services in Ha Giang province in the order of importance is as follows: The level of organization and management of the tourism industry (QL), The participation of the community in the development of community tourism (TG), Tourism Resources (TN), Infrastructure Development (HT), Human Resource Training Development (NL). This result is the basis for us to choose appropriate solutions to improve the quality of community tourism services in Ha Giang province in the future.

International journal of business and social science research

The rapid growth of wireless devices introduces a diverse range of applications and requires intelligent hardware platforms that integrate computing, sensing, and wireless connectivity in a compact systemon- chip (SoC). This paper presents a low-power, high-performance SoC platform that supports dynamic power management and secure communication. The SoC platform consists of 16-/32-bit programmable ARM9 cores, a power management unit with multiple low-power modes, analog and digital peripherals, and security engines. A complete tool-chain with an automatic platform generator has also been developed to ease and accelerate the application development. Fabricated in a 65 nm CMOS technology, an implementation of the proposed platform occupies an area of 1.0 × 1.7 mm2.

Dr h shaheen

A 22-year-old Indonesian woman was admitted through the emergency department with a 10-day history of  fever associated with chills. Other medical history was unremarkable. On examination, she appeared ill; BP 95/60 mmHg, pulse 105/min, and temperature 39.5°C. Abdominal examination showed splenomegaly; examination of the heart, lungs, and nervous system was unremarkable.

Karishma

The space-time dynamics of chlorophyll a concentration and seawater excess viscosity has been investigated in the hydrographically contrasting inshore and offshore water masses of the eastern English Channel. This was done during the phytoplankton spring bloom dominated by Phaeocystis globosa before and after the very large-scale formation of foam induced by an increase in wind-driven turbulence and the related wave breakings. The results suggest that the dynamics of chlorophyll a concentration and seawater excess viscosity are differentially controlled by the formation of foam through the intensity of the spring bloom and wind-generated turbulence.

Irma kesaulya

The concept of inherited memories, where experiences from one generation can influence the traits and behaviors of subsequent generations, has long captivated scientific curiosity. Recent advancements in epigenetics have provided compelling evidence for the potential mechanisms underlying this phenomenon. This focused brief review article outlines the current state of knowledge on inherited memories, examining the transgenerational effects observed in animal models, the epigenetic mechanisms involved, and the environmental influences that shape these heritable traits. Additionally, Highlights about emerging areas of inquiry were explored, including the cross-generational transmission of social behaviors, the evolutionary implications of inherited memories, and the ethical considerations surrounding research in humans. Thus, a unique perspective could be deduced from this rapidly evolving field and accordingly, further research could be stimulated into the implication of inherited memories.

Mostafa eissa

The skin provides an effective barrier and only limited number of drugs can penetrate in adequate amounts. This study aims to identify the relationship between the physicochemical properties and permeation across mouse skin of non-steroidal anti-inflammatory drugs in view of their feasibility to transdermal delivery. Biphenylacetic acid, diclofenac base, diclofenac sodium, indomethacin and piroxicam are the drugs studied. Number of physicochemical properties studies were performed. Drug permeation studies across hairless mouse skin were carried out using an in-vitro finite dosing diffusion cell. The relationship between physicochemical properties of the drugs studied and their percutaneous penetration was studied. Purity for the compounds studied ranged from 99.09% to 100% in which 99.89% purity was obtained for diclofenac base. At 7.4, the % ionized of piroxicam was found to be 95.12%, while for other drugs were in the range of 98.01% and 99.96%. The true partition coefficient values in the n-octanol/water system are in the range of 1.85 and 2.85, while in the n-octanol/phosphate system ranged from 2.14 to 3.70. Observed solubility in water, phosphate buffer and n-octanol ranged from 0.033 to 0.322, 0.202 to 0.329 mg per ml, and 2.19 to 16.10 mg per ml, respectively. A linear relationship was found between water solubility and melting point between steady-state rates of permeation across intact and viable skin, between n-octanol solubility and maximum predicted flux and between molecular volume and the ratio of maximum predicted flux. Predicted flux calculated was compared with the experimental data which resulted in a high correlation. Physicochemical criteria which were determined the feasibility of non-steroidal anti-inflammatory drugs studied for transdermal delivery were identified. The relationships obtained in this study provide an essential physical and chemical properties that govern transport of non-steroidal anti-inflammatory drugs across hairless mouse skin.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: While osteoporosis increases the risk of fragility fractures, bisphosphonate has been proven to increase bone strengthand reduce the risk of vertebral and non-vertebral fractures. In addition to its efficacy, substituting the brand with generic medication isa strategy to optimize healthcare expenditures. This study aimed to evaluate the efficacy of generic alendronate treatment and assesspotential adverse events in patients with osteoporosis.Materials and Methods: A retrospective review was conducted on 120 patients who met the indications for osteoporosis treatment,received weekly generic alendronate (70 mg) for >1 year, and underwent evaluation through standard axial dual-energy X-rayabsorptiometry (DXA). The outcomes of this study were the percent change in bone mineral density (BMD) at the lumbar spine,femoral neck, and total hip after one year of treatment. The major adverse events occurring during medication that led to thediscontinuation of drug administration were documented.Results: Most patients were female (96.7%) with an average age of 69.0 ± 9.3 years. The percent change in BMD increased at all sitesafter one year of generic alendronate treatment (lumbar spine: 5.6 ± 13.7, p-value <0.001; femoral neck: 2.3 ± 8.3, p-value = 0.023;total hip: 2.1 ± 6.2, p-value = 0.003), with over 85% of patients experiencing increased or stable BMD. Three patients discontinued themedication due to adverse effects: two had dyspepsia, and one had persistent myalgia.Conclusion: Generic alendronate may be considered an effective antiresorptive agent for osteoporosis treatment with a low incidenceof adverse effects

Saran malisorn

Background: In a Benghazi medical center, this observational study assessed the role of laparoscopic cholecystectomy (LC) in the early stages of acute gallbladder illness. Materials and Methods: From January 2022 to December 2022, all emergency and urgent admissions for acute gallbladder disease were identified, and additionally, data from hospital medical records were then evaluated retrospectively. Results: Out of a total of 334 patients with gallstone diseases, we found 321 individuals (206 with acute biliary colic, 115 with acute calculous cholecystitis), and 13 with acalculous cholecystitis. Early laparoscopic surgery for acute calculous cholecystitis had a greater conversion rate than procedures for acute biliary discomfort (19% vs. 4%; p=0.002). When surgery was performed 72 h from the onset of the symptoms for patients with acute calculous cholecystitis, the conversion rate was considerably lower (one out of 25) than when surgery was postponed past 72 h (14 out of 53) or later performed electively (seven out of 23) (p=0.014). In comparison to elective surgery for acute biliary colic (three of 66), elective surgery for prior acute cholecystitis was linked to a higher conversion rate (seven of 22 patients) (p=0.002). Conclusion: LC for acute calculous cholecystitis needs to be done within 72 h of the onset of symptoms, and it is worthwhile.

Karishma

Poor water quality and lack of access to improved sanitation continue to pose a significant threat to human health. The burden of disease analysis suggests that lack of access to safe water supply, sanitation and hygiene is the third most significant risk factor for poor health in developing countries with high mortality rates. Diarrhoea is the leading disease associated with unsafe water supply, sanitation and hygiene and is responsible for the deaths. The study observed that out of the 150 respondents, 37% are 31-40 years, followed by 20-30 years with 32%. 130 (86.7%) respondents have got married, and 61% of the respondents are female. 85% adopted the nuclear family system, and 50% of respondents are illiterates in the study areas. 85% of respondents are daily wage earners, 37%are earnings rupees between 2000-2500 per month. 27% of respondents are landless labours, and 37% of households possess below 2 acres of land. 40% of respondents suffer from health problems, and 44% consume rice as their staple food. 62% of respondents have debts, and 33% got from money lenders. 62% of respondents do not have toilet facilities and go open defecation. 92% of respondents stated that toilet makes dignity, saves time and energy, saves their children school days, makes adolescent girls privacy, save wage loss, and toilet makes quality life.

B suresh lal

Hydatid disease or hydatidosis is a worldwide zoonosis disease caused by the tapeworm of Echinococcus granulosus and still widely endemic in Tunisia especially in rural areas where the sheep-dog cycle is dominant. It is an important public health problem in the pediatric age group causing significant morbidity and mortality. We report a case of primary hydatid cyst of the small intestine in a child and we want to highlight the difficulty that we meet in the diagnosis despite the contribution of imaging.

Sameh

Immunoglobulin G4-related disease (IgG4-RD) is a rare and new but increasingly recognized immune-mediated fibroinflammatory condition known to affect multiple organs. The diagnostic approach is challenging, as there is no single investigation to confirm the diagnosis, which requires the integration of clinical, biochemical, and radiographic manifestations with classic histopathologic features to establish the diagnosis. The histology of IgG4-RD is determined by a dense lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis in the presence of an increased level of IgG4 in most patients. The first line of treatment is systemic glucocorticoids, but adverse effects of the drug, suboptimal response, and disease recurrences on reduction or termination of therapy highlight the need for an alternative therapy such as rituximab, which appears to be a promising alternate agent in the treatment of IgG4-RD; however, its efficacy needs to be evaluated in large clinically controlled trials.

Karishma

Abstract: Objective: To evaluate the Antiparkinson activity of Allium sativum in Haloperidol induced Parkinson‟s disease in mice. Method: Parkinson‟s disease was induced by administering haloperidol (2.0 mg/kg i.p.) Daily for a week. The mice were divided into 5 group (n=6). Group II received haloperidol (2mg/kg body weight).Group III received combination of levodopa and carbidopa (100mg+ 10mg/kg by i.p along with haloperidol) and Group IV and V received Allium sativum extract (200 and 400mg/kg by p.o), respectively for 7 days along with haloperidol. To evaluate the antiparkinson effect of Allium sativum, catalepsy bar test, rotarod test, hang test and horizontal bar test were used. One way ANOVA was used to test statistical significance followed by Bonferroni multiple comparison tests .Results: Allium sativum extract (200 and 400mg/kg by p.o) was found to decrease the duration of catalepsy significantly (P<0.001) in catalepsy bar test as compared to haloperidol group, and significantly increases (P<0.001) fall off time in, rotarod test, hang test and horizontal bar test respectively as compared to haloperidol group. Conclusion: The result of the present study conclusively shows the Antiparkinson‟s activity of Allium sativum in haloperidol induced Parkinson‟s disease in mice.

Zeenath banu