Dengue is an acute infection disease caused by a flavi virus (species Dengue virus of the genus Flavi virus), transmitted by female mosquito aedes mosquito, infection has globally become a major public health concern since the incidence of the dengue fever has increased more than 30-fold over the last decades. The dengue fever has been a most important public health problems since many years and the various outbreak of the dengue cases has been seen time to time. One of the reasons for the increasing and time to time outbreak of the dengue may be the reason of climate change, global warming, lack of knowledge about signs, symptoms, transmission, preventive measure and lack of ignorance or lack of the preventive practice of the dengue fever. Method: Descriptive, cross-sectional study on 192 head of household's was study population residing in Kanchan RM, Rupandehi Respondent was selected using Non probability judgmental sampling techniques by face-to-face interview was used. Result shows 58.3% good knowledge and 62% good practice. Knowledge was found to be associated with Age, Types of family, Size of family, educational level and Family suffered from dengue. Preventive practice was found to be associated with the Ever heard from health professional. Study will contribute towards development of appropriate policy strategies at local level that will tackle the problem associated with the knowledge and preventive practice of DF and provide a basis for future research on this area. Inferential analysis shows that there is significant association between the level of knowledge with age, types of family, size of family, educational level and family suffered from dengue and the level of preventive practice was associated with the ever heard from health professional.

Raju khanal

The United Kingdom (UK) is a constitutional monarchy where the Head of State is currently the Queen (part of the monarch) rather than the president. The roles, functions, and power are considered via convention, among them being that the monarch should be neutral politically (Bodleian Libraries 2021). The UK has three legal systems for England and Wales, Scotland, and Northern Ireland (Rab 2021). The former two nations use the common law system combining the approval of legislation by parliament, which includes the Monarch, House of Commons, and House of Lords, and the creation of precedents via case law (Rab 2021). The House of Commons is elected the population, with the Prime Minister being a traditional member of the House (Rab 2021). On the other hand, the judiciary is appointed to control the Court System and case law and is separate from the Parliament (Bodleian Libraries 2021). However, these systems are the UK law emanating from applicable laws to the UK, including its citizens. The UK law is summarized in the concept map highlighting the different types of laws governing the UK

Zamzam abdelazim

A study of knowledge seeking behaviour of users is essential for evolving suitable guidelines for knowledge organisation and processing. The features of knowledge organisation and its use in problem-solving and decision-making are explained. Classification plays an important role in knowledge organisation. An understanding of mental models and mental maps helps in information needs of users effectively. The schemes classification in knowledge processing is highlighted. The paper examines the scope of knowledge organisation in the modern technology and its application.

Subhash reddy b

This paper aims to study the restructuring and change management of SARHS, which in turn will be accompanied by some complex, difficulties and discussions that may include personnel emotion, which must be taken into account. We will guide SARHS managers by conducting a comprehensive study of majority factors that will affect the success of the process, considering and covering all views. Which will result in the dismissal of some employees and the closure of their jobs permanently in the new job structure. The study will include many theories, models and justified recommendations to be followed to ensure a successful and safe restructuring and management change free from unresolved impediments and difficulties that could lead to a setback. Finally, restructuring is not a result but the beginning of a new process

Mohamed sorogy

Aminopyrine (AM) has been used as a model substrate for investigation of drug metabolism. The major metabolic route is N-demethylation that was confirmed in liver microsomes. The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating the N-demethylation of 4-di-methylaminoantipyrine (4-DMAA) to 4-methylaminoantipyrine (4-MAA). The contribution of human CYP to the metabolism of (4-DMAA) to (4-MAA) in human was investigated using virus expressed human CYP, human liver microsomes with chemical inhibition studies. The substrate of 4-dimethylaminantipyrine was employed at different concentrations (11.5, 23, 46, 115 and 230 µmol per l) with varying concentrations of selective inhibitors of CYP (CYP1A2), (CYP3A4), (CYP2C8),(CYP2A6), (CYP2D6), (CYP2C19) and (CYP1A1). 4-DMAA and 4-MAA were analysed by HPLC and enzyme kinetic parameters (Km and Vmax) were calculated from the concentration data. The transformation of 4-dimethylaminoantipyrine to 4-methyaminoantipyrine by microsomes prepared from baculovirus-expressed human CYP was pronounced with CYP2D6. The metabolism of 4-dimethylaminoantipyrine was inhibited by 60.0% and 55.17% by a concentration of 100 µmo per l of the known CYP2D6 inhibitors quinidine and moclobemide. The corresponding Ki values were 0.050 and 0.11 mM, respectively. The corresponding IC50 values were 0.06 and 0.13 mM, respectively. The enzyme CYP2D6 apparently has an important role in N-demethyl-ation of 4-dimethylaminoantipyrine.

Mediterranean journal of pharmacy and pharmaceutical sciences

Hepatitis B virus infection is a major health problem worldwide. More than 400 million people are suffering from this infectious disease. Alhagi Maurorum (camel thorn, CTE) is used in Libyan folk medicine for hepatitis. The aim of this study is to investigate the effect of the camel thorn on the hepatitis B virus. After a pharmacological and toxicological screening of camel thorns on experimental animals in our laboratories, in an open-label study, 15 patients of either gender were chosen at random with their consent (consent form signed). The patients had no liver cirrhosis and were not alcoholics. Following clinical testing, the patients were given a low, safe dose of camel thorn powder (2.6 g soaked in boiling water for 10 minutes) three times per day for six months. The viral load was measured before treatment and three and six months after the beginning of the experiment by polymerase chain reaction. The complete blood picture, the level of transaminases, bilirubin, creatinine, blood glucose, lipid profile, thyroid function, and prothrombin were assessed before and after three months after the beginning of the experiment. Our data showed no significant changes in the complete blood picture, creatinine, blood urea, glucose level, bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lipid profile, prothrombin, and thyroid function. The levels of viral load before, three months after, and six months after the beginning of our study were 1689 ± 289, 558 ± 160, and 271 ± 026 IU per mL, respectively. From this study, we may conclude that the camel thorn is safe and showed activity against viral hepatitis B, however, further investigations are needed by increasing the number of patients and using higher doses of plant extract to explore its mechanism of action. Finally, the mechanism of camel thorn may be related either to its antiviral effect or to the stimulation of either endogenous interferon or the immune system.

Mediterranean journal of pharmacy and pharmaceutical sciences

Overall, disability refers to a physical or mental state that impairs an individual's ability to function in daily life. It suffices to say that disability is a medical-social issue that affects both the family and the nation. In a country like India, where girl children are frequently stigmatized as a burden on society, the condition of girl children with special needs is frequently subject to carelessness, lack of compassion, and illiteracy. Though the situation has improved slightly since the introduction of inclusive education, the situation is critical for tribal girl students with special needs. In a fragile socioeconomic environment, tribal girls are already vulnerable to high dropout rates, early marriage, and an ignorant attitude from family members, but the situation is pitiful for tribal girls with special needs. The tribal girl students with special needs suffer quadruple discrimination of being female, being disabled, being ST, and being socio-economically backward. Here, intervention through artificial intelligence (AI) and AI-assisted devices can be critical in overcoming the barriers encountered by tribal girl students with special needs in the process of inclusion and development

Souren bhattacharya

Abstract Background. Numerous studies have found that various core muscles are involved in subjects with chronic low back pain. The evidence for profiles of respiratory muscle involvement in normal low backache subjects has not been reviewed explicitly for low back pain. Aims. The study’s primary objective was to scientifically analyze, condense, and to evaluate the evidence for the involvement of respiratory muscles in subjects suffering from chronic low back pain. Methods. This evaluation procedure will trail the guidelines of PRISMA and MOOSE. The assessors will use a custombuilt tool to extract data from the studies, regardless of the methodology used. A modified Downs and Black index will be used to assess the superiority of the methods used in the selected studies. Results. This index evaluates the characteristics of the subjects, the timing of the outcomes, and the characteristics of the interventions, and quantitative, formal analysis, so-called meta-analysis, is performed if necessary. The study’s effect, including the evidence, will be determined using the GRADE a framework for a systematic approach. Earlier research has found that core muscles are involved, and the interventions are tailored to include deficiencies and intrusions that target specific muscle groups. Conclusion. As an additional component that can be targeted by clinical practitioners in their day-to-day practice and added to rehab programmes, this systematic review protocol will summarise the list of evidence available for the rehabilitation of low back ache and highlight the involvement of respiratory muscles in lowback ache subjects. Keywords: chronic low back pain, diaphragmatic breathing exercises, respiratory muscles.

Nagaraj sibbala

This conceptual paper critiques the overgeneralized adoption of hybridity in translation studies, exposing its theoretical circularity, lack of actionable strategies and weak methodological grounding. Although hybridity is often conceptualized as a means of cultural negotiation, its translation-specific application remains underdeveloped. Bhabha’s “third space” metaphor is frequently cited but without translating it into actionable strategies, with existing applications being viewed either as too niche or essentializing cultural binaries. Therefore, the ethical dilemma of striking a balance between source text authenticity and target text accessibility remains unresolved, with actual translation decisions often oscillating between two extremes, either reinforcing or subverting hegemonic structures. To close this gap, this research proposes a dynamic hybrid model which puts practical strategies into action to overcome theoretical limitations of hybridity. The model draws on Joseph Malone’s practical strategies to combine foreignization and domestication in a dynamic framework which enables translators to maintain essential cultural elements while achieving clarity. The model presents a practical hybrid approach to literary translation, one that maintains a balanced harmony between faithfulness and accessibility.

Faisal khalifa

Aim: Murraya koenigii is a widely used plant both as a potential medicinal agent and also for common cooking purposes. Aim of this present study was to determine the antimicrobial activity of Murraya koenigii leaf extracts on Staphylococcus aureus and Escherichia coli. Study Design: Screening and isolation of pathogenic bacterial strains from contaminated water. Preparation of Murraya koenigii leaf extracts using petroleum ether, acetone and ethyl acetate by using serial extraction method with Soxhlet apparatus. Place and Duration of Study: Department of microbiology, Agro biotec research centre Ltd, Poovanthuruthu, Kottayam, Kerala, India, between 2014 January to 2014 May. Methodology: Staphylococcus aureus and Escherichia coli were the bacterial strains used in this study. Morphological and biochemical analysis of microorganisms were conducted to identify the strains. Leaf extracts (petroleum ether, acetone and ethyl acetate) of Murraya koenigii were screened using MHA disc diffusion methods. Results: Various concentration of plant extracts were used to check its activity against isolated pathogens. Acetone extract of curry leaves exhibit maximum zone of inhibition against Staphylococcus aureus and petroleum ether extracts shown maximum inhibition against Escherichia coli.

Dr. hemand aravind | sr.research scientist | abtec ltd

Lexical and structural levels of language abound ambiguities that are good source of humor. Consequently, violations of the maxims of conversation are leeway to induce humor in any type of discourse. Adding these two precepts and considering pragmatics as its foundation became the bases in analysing the top-grossing films of Vice Ganda. It sought to identify the verbal linguistic jokes and ambiguities present in the top-grossing films of Vice Ganda; determine on how these ambiguities create devaluation of Grice’s maxims of conversation; and determine on how the ambiguities in verbal linguistic jokes and devaluation of Grice’s maxims of conversation were used as ingredients in Vice Ganda’s top-grossing films. Discourse analysis was used in the study and the analytical framework to induce humor by Taghiyev (2018) was used in analysing the corpora. A priori coding was used to identify the recurring ambiguities and devaluation of maxims in the films. Findings show that lexical-semantic and structural-syntactic ambiguities were present in the films. It was intentionally used in order to create humorous effect in the dialogues of the films. Moreover, the devaluation of the maxims of conversation quietly and unostentatiously, opting out, coping with a clash between maxims, and flouting was deemed an effective ingredient to make the films become comical and appealing to the audience.

Darrel ocampo

Treatment adherence is a critical component of epilepsy management. Antiepileptic drug side effects affect adherence and may result in the discontinuation of medication. This study aimed to investigate the association between antiepileptic drug side effects and medication adherence among Libyan patients with epilepsy while identifying predictors of adherence. A cross-sectional study was conducted at Tripoli University Hospital involving 200 adult epilepsy patients. Adherence was assessed via a self-report tool dichotomized as adherent/ non-adherent if patients stopped medication due to side effects. Side effects were evaluated using the Side Effects of Antiepileptic Drugs questionnaire. Logistic regression analyzed predictors of adherence, including antiepileptic drug use, therapy regimen, and side-effect profiles, with p<0.05 declared association. The overall adherence rate was 87.0%. Higher adherence was observed in older age groups, 95.8% in patients aged 51-60, 89.4% in married patients, and 91.0% in university-educated patients. Patients on monotherapy and those seizure-free in the preceding month demonstrated better adherence (88.4% and 93.0%, respectively). Valproate users had notably low adherence (52.6%) while carbamazepine and phenytoin users showed higher adherence (89.7% and 91.7%, respectively). Cognitive complaints significantly reduced adherence (76.1% vs. 79.6%), as did aggressive behavior (58.3% adherence). Logistic regression identified two independent predictors: patients on old-generation antiepileptic drugs had 2.7 times higher adherence (AOR=2.702, 95% CI: 1.168-6.249; p=0.02) while cognitive side effects reduced adherence by 86.4% (AOR=0.136, 95% CI: 0.031-0.596; p=0.008). Cognitive side effects predict non-adherence, necessitating routine monitoring. Paradoxically, older antiepileptic drugs correlated with better adherence. Integrating patient-reported metrics and addressing cognitive impacts could optimize epilepsy care, highlighting gaps in side-effect management and advocating personalized strategies in clinical settings.

Mediterranean journal of pharmacy and pharmaceutical sciences

: About 12% of the world population is affected by different forms of urolithiasis, the recurrence rate of which is 47-60% in females and 70-80% in males. According to WHO, 75% of people rely on traditional medicines to prevent and cure different ailments. Similarly, the majority of the world population uses several plants to treat problems related to the urinary tract system, of which urolithiasis is the primary cause. The review aims to collect data on the plants used in different parts of the world and cultures against urolithiasis, including their parts, mode of preparation, dosage, and administration. A literature review was conducted for traditionally used antiurolithiatic plants. The articles mentioning plant, parts, mode of preparation, dose and route of administration were selected. This information was extracted to compose Mono and Polyherbal antiurolithiatic formulations used in Appalachia (a region in the Eastern United States), Canada, India, Iran, Israel, Italy, Jordan, Latin America, Pakistan, Turkey and Yemen. The review provides essential data about plants used as antiurolithiatic in different parts of the world. The information is not only useful for ordinary people but also for the scientific community to carry out further phytochemical, pharmacological and toxicological studies for discovering new, effective, safer molecules against urolithiasis.

Dr. salman ahmed

Ketorolac tromethamine, the non-steroidal anti-inflammatory drug, was formulated into mucoadhesive films to overcome the limitations in the currently available dosage and routes of administration which in sequence will increase patients’ compliance. Films were cast from organic and aqueous solvents using various bioadhesive polymers namely: HPMC E-15, Eudragit RLPO, Eudragit RSPO, Carbopol 934P. The prepared films were subjected to investigation for their physical and mechanical properties, swelling behaviors, in vitro bioadhesion, drug permeation via bovine buccal mucosa, and in vitro drug release. These properties were found to vary significantly depending on the preparation methods, the type of the polymers, and the ratio of addition of both plasticizers (i.e. polyethylene glycol and film forming agent. Formulation F4 is selected for best formulation because it shows the 98.85% drug release at time 6 hr. In addition, this film was subjected to in vitro and in vivo release. The obtained results indicate that the concentration of ketorolac in the oral cavity was maintained above 4.0 µg/ml for a period of at least 6 h. This film shows promising results for using the ketorolac mucoadhesive route of administration topically and systemically, and thus it will be subjected to clinical evaluation in future work.

Kuldeep vinchurkar

In Libya, mothers commonly use natural products for their infants. The purpose of this survey was to evaluate the level of awareness of mothers using natural products for their infants, a validated questionnaire-based survey was distributed for mothers in several hospitals, the selected random group included 152 mothers of infants aged from day one birth to one year old, an analysis of the data revealed that 68% of mothers were using natural products and the most predominant age was between 20 - 30 years, 63% were living in Tripoli and 52% were undergraduate level of education. Further statistical analysis was revealed a significant difference for measuring the degree of awareness of all the natural products combined together (p = 0.001) and a similar degree of significant difference to the degree of awareness of each natural product alone (p = 0.001). A correlation coefficient test by Spearman was preformed to evaluate if there is any association between participants’ demographic data and the question which measures the level of mothers’ awareness. The results showed that mothers have no awareness on how to use these natural products and no correlation between the participants’ demographic data and the way the mothers use these natural products, except between the fennel and the education level (p = 0.033, p < 0.05, respectively). In conclusion, mothers have no awareness on how to use natural products, an appropriate attention by health care providers should be given to nursing mothers for herbal use.

Mediterranean journal of pharmacy and pharmaceutical sciences

The anti-emetic activity of the leaves methanolic extracts of Cassia angustifolia Vahl., Cassia holosericea Fresen., Cassia italica Miller. Lam. ex F.W. Ander and Cassia purpurea Roxb., was evaluated in young chicks. Emesis was induced by copper sulfate (50 mg/kg), and the extracts were tested orally at a dose of 150 mg/kg. All the extracts significantly decreased the number of retching (p < 0.05 and p < 0.01) compared with standard chlorpromazine.

Dr. salman ahmed

Dietary fatty acid composition in broiler influences carcass quality by altering fat deposition and fatty acid profile. Thus, the study was carried out to evaluate the effect of incorporation of rapeseed oil in broiler ration on omega-3 fatty acid concentration of carcass and its traits in broiler chicken. A total of 160 day-old straight run broilers (Vencobb 400) were randomly divided into four treatment groups (G1, G2, G3 and G4) having four replicates of ten chicks each. The basal diets (G1) were prepared to meet BIS (2007) nutrient requirements with palm oil at 1.5, 3, and 4.5 per cent in pre-starter, starter and finisher diets, respectively. The experimental diets were broiler rations prepared with rapeseed oil replacing 25, 50 and 100 per cent of palm oil in G2, G3 and G4 diets, respectively. The diets were fed ad libitum till 6 weeks of age. Six birds from each group were randomly selected and slaughtered on 42nd day to study omega-3 fatty acid concentration of carcass and its characteristics. The crude fat content of breast and thigh muscle was significantly (P<0.05) reduced in the group fed rapeseed oil included diets. However, carcass yield, processing yield and meat to bone ratio of cut up parts was not significantly affected. The colour and pH of breast and thigh muscles were similar among the treatment groups. Omega- 3 fatty acid concentration was significantly (P<0.01) increased in both breast and thigh muscle of G4 group broilers compared to G1 group. Thus, rapeseed oil inclusion in diet significantly increased omega-3 fatty acid concentration and significantly reduced crude fat concentration breast and thigh muscles with no effect on the carcass yield and its quality when included in the diet replacing palm oil at different proportion

Senthil murugan

Lakes are characterized by dynamic responses to ecological and limnologic disturbances that occur within a constrained timeframe. Some endorheic lakes in the Kenyan Rift valley are presently regarded as environmental hotspots because of complex changes that are revealed through multiple proxies; changing lake levels and surface area, turbidity and sedimentation, and the proliferation of macrophytes, and loss of aquatic biodiversity. Lake Baringo is characterized by widespread catchment degradation accompanied by high levels of turbidity during erratic and decline of the native fishery based on Oreochromis niloticus baringoensis. A careful analysis implicates potential natural factors such as catchment topography and increasing anthropogenic pressure as the main causes of lake ecosystem degradation. This paper recommends several strategies for restoration of Lake Baringo based on an integrated multi-faceted approach that combines catchment rehabilitation, pollution control, and provision of alternative livelihoods such as agriculture to the riparian communities

Omweno job

The screening of perfect diuretics for non-clinical utility in Diabetes mellitus is a relatively novel approach which gain inssight into underlying the pathophysiological processes. This study is aims to evaluate the diuretic effect of a crude aqueous & alcoholic extract of M.charantia Linn. using Albino Wistar Rat model. In this study, the comparative observation of Diuretic activity with standard and extracted compound were shown that the estimated 24‐hour urine contains the Na+ - 3.82 g, 3.82 g, 3.92 g and K+ - 1.35 g, 1.39 g, 1.48 g wt. for Vehicle control, Standard drug, and Extracted compound respectively. Which possess the favoring result means from the spot urine were 10.7±7.0 g/24 h and 3.9±2.1 g/24 h, respectively. Coefficients were 0.035, 0.022, 0.046 at (d±2SD = 7.07 g, 4.42 g and 8.92 g) for sodium chloride and 0.068, 0.031, 0.046 at (d±2SD =4.92 g, 2.31 g, and 3.34 g) for potassium chloride. The Na+ and K+ results can be deduced by conversion (1 g NaCl=0.4 g Na+, 1 g KCl≈0.5 g K+). The present study guide formulation of non clinical trials with statistical study to further measuring the claimed efficacy of M. charantia as a natural remedy for diabetes mellitus.

Dr. wahul umesh b

Personnel Department is the predominant component of HRD unit of North Eastern Karnataka Road Transport Corporation (NEKRTC), though HRD has been identified and designated as a separate Department. Basically the existing Personnel Department is qualified to be called HR Department OR even a better name would be Human Resources Management Department, since it would correctly reflect the comprehensive and all inclusive nature of the functions of the existing Personnel Department, which covers all features of Human Resources Management, namely Forecast of requirement of Human Resources, Planning for Recruitment, In-service care Co-ordination, Control and Regulation as also Retirement and all matters related to Personnel Administration. It should be its function to plan for training appropriately along with recruitment of personnel from all the Departments. The present Human Resource Development. Is ill-equipped and does not have the comprehension of concept and perception of HRD.

Dr.kailaspathi vishwakarma